Antibody Induction of Lymphocyte-Mediated Cytotoxicity against Human Transitional-Cell Carcinomas of the Urinary Tract

Antibody-dependent and spontaneous lympholysis in urologic cancer patients

“…ADCC has been shown by Hakala et al (1974) to be operative in some patients with transitional-cell carcinoma, and therefore may be of clinical importance. Moreover, in animal tumour systems, spontaneous lympholysis has been postulated a natural cell-mediated surveillance mechanism against oncogenic viruses and tumour cells (Kiessling et al, 1976;Herberman et al, 1975) and a similar role has been postulated in humans (Pross & Baines, 1977).…”

Human antibody-dependent cellular cytotoxicity. Isolation and identification of a subpopulation of peripheral blood lymphocytes which kill antibody-coated autologous target cells.

“…In addition, recent studies have also shown that patients with transitional cell carcinoma (TCC) can develop antibody which specifically renders cultured TCC cell lines susceptible to ADCC killing by patient lymphocytes (27,28). Thus, evidence is mounting that ADCC is an ubiquitous immune cytotoxic mechanism, at least in vitro.…”

Serological and Biochemical Analyses of M Components in Patients with Transitional Cell Carcinoma of the Urinary Bladder

“…Such ob servations, in conjunction with the frequent occurrence of antitumor antibodies in tumor patients [11,23], point to a possible rela tionship between M components and antitu mor antibodies in at least some cancer pa tients. In our previous studies, we found that M components in patients with carci noma of the colon have more structural similarity among themselves than with other unrelated monoclonal immunoglobulins [30,31], In the present study, we obtained simi lar results for M components in patients with another kind of solid tumor, TCC.…”

“…An tibodies may serve as mediators of anti body-dependent cell-mediated cytotoxicity against epithelial tumors [15,23], or they may block the cytotoxicity of lymphocytes [13]. In previous studies of transitional cell carcinoma of the urinary bladder (TCC), Hakala et al [11] and others [2,7,14,24], employing microcytotoxicity assays with sera from 60 TCC patients, demonstrated the presence of serum immunoglobulins of the IgG class which activated specific cyto toxic lymphocytes. These antibodies did not fix complement but required the presence of B lymphocytes bearing Fc receptors for specific cytotoxicity directed against target cells from the kidney, pelvis, ureter, and urinary bladder but not against cells from other organs.…”