Antibody imaging in breast cancer

Nabi, Hani A.

doi:10.1016/s0001-2998(97)80034-7

Cited by 18 publications

(4 citation statements)

References 25 publications

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“…Many studies have demonstrated tumor location using monoclonal antibodies and derived reagents in both animal models and humans. The subject has been reviewed extensively in both comprehensive and specialized reviews, to which the reader is referred for details: Sands (1990), Goldenberg and Larson (1992), Goldenberg et al (1995), Hall (1995), Bodey et al (1996), Harrison and Tempero (1996), Pastan et al (1996), Youle (1996), Hoang-Xuan andDelattre (1996), Greiner et al (1996), Jurcic et al (1996), Reisfeld and Gillies (1996), Hellstrom et al (1996), Nabi (1997), and Zuckier and DeNardo (1997). Despite occasional successes, monoclonal antibodies have not yet found general use in either tumor location or therapy.…”

Section: Advantages and Difficulties Of Tumor Targeting Using Monoclomentioning

confidence: 99%

Tumor Detection and Visualization Using Cyanine Fluorochrome-Labeled Antibodies

et al. 1997

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Tumor localization using fluorescence has been made practical by current improvements in tumor targeting molecules, especially monoclonal antibodies and their derivatives, by the development of convenient near-infrared emitting fluorochromes and by the availability of digital cameras having high sensitivity in this spectral region. Recent studies in animals have demonstrated that fluorochrome labeling of monoclonal antibodies confers adequate sensitivity and improved resolution. Distribution and catabolism of fluorochrome-labeled and radiolabeled antibodies are similar. Simultaneous localization of multiple reagents is made possible by labeling with several different near-infrared emitting fluorochromes; thus background subtraction and differential labeling of multiple tumor-associated components can be performed. Difficulties in using the fluorochrome labels are mainly related to light scattering and absorption in tissues, but detection of small tumors at depths of several millimeters is feasible. The major medical use of this new technology is likely to be endoscopic location of tumors. Scientific uses include studies of tumor metastasis, uptake and distribution of drugs and tumor-targeting molecules by tumors, and migration patterns of near-infrared labeled cells in vivo.

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Section: Advantages and Difficulties Of Tumor Targeting Using Monoclomentioning

confidence: 99%

Tumor Detection and Visualization Using Cyanine Fluorochrome-Labeled Antibodies

et al. 1997

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“…High scintigraphic yield has also been reported for 99m Inlabelled m170 with 90% sensitivity, 93% specificity and 92% accuracy concerning the detection of both primary and metastatic breast cancer lesions measuring less than 1 cm in diameter [McEwan et al, 1994]. Similar results for breast cancer detection have been shown by the use of satumomab (OncoScint, Cytogen Corp, Princeton, NJ USA), which consists of 2 mg of B72.3 MAb labelled with 111 In [Nabi., 1997, Khalkhali I et al, 2001]. …”

Section: Radioimmunoscintigraphymentioning

confidence: 75%

“…In most cases, breast cancer cell lines produce CEA, although only a slight increase of serum CEA levels above normal may appear [Lind et al, 1991]. Regarding the detection of lymph node breast cancer metastases by arcitumomab, the commercially applied kit of anti-CEA MAb (CEAScan, Immunomedics, Morris Plains, NJ, USA), it has achieved 75% sensitivity, 83% specificity, 80% accuracy, 75% PPV and 83% NPV [Nabi, 1997, Goldenberg et al, 1999. The method has not gained access into routine clinical practice though, because false-positive results are frequent due to tracer uptake by inflammatory lymph nodes, the technique is relatively complex owing to the slow tracer kinetics and biodistribution and the radiolabelled MAbs can hardly be obtained.…”

Section: Lymphoscintigraphy and Lymphoimmunoscintigraphymentioning

confidence: 99%

Scintimammography - Molecular Imaging: Value and New Perspectives with 99mTc(V)-DMSA

Papantoniou¹,

Valsamaki²,

Tsiouris³

2012

Imaging of the Breast - Technical Aspects and Clinical Implication

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“…Imaging of regional lymph nodes in breast carcinoma patients by immunolymphoscintigraphy also has been found to be feasible with CEA antibodies 56, 57. In studies performed subsequently, different radiolabeled antibodies to CEA and other breast carcinoma markers confirmed the detection and localization of breast carcinoma 42, 58–62. Arcitumomab is a CEA specific monoclonal antibody Fab′ fragment approved in the U.S., Canada, and Europe as a technetium‐99m ( 99m Tc) labeled imaging agent for the detection of metastatic/recurrent colorectal carcinoma.…”

mentioning

confidence: 94%

Commentary: Do biology and chemistry educators talk to each other?

White

2007

Biochem Molecular Bio Educ

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"Biology cannot ignore chemistry, as much as I wish it could . . . " John Maynard Smith [1] At a meeting a couple of years ago, a biochemist characterized his frustration about introductory chemistry and biology courses at his school as "five hundred years of separation." That was the cumulative time that his colleagues in the biology and chemistry departments had been teaching and apparently never talked to each other about what they taught or what their respective students needed from the other's courses despite the fact that often, more than 50% of the students taking introductory biology take general chemistry simultaneously. I sense that five hundred years of separation is common at many schools. Well over a decade ago, policy makers recognized the problem and made recommendations for integration [2], but change comes slowly.A quick look at course syllabi and textbooks for introductory biology reveals that many students begin biology with the chemistry of life. Topics include water, pH and buffers, osmotic pressure, nucleotide and amino acid structures, hydrophobicity, and a variety of other chemistry topics. Ironically, freshmen college students encounter many of these topics for the first time in introductory biology rather than in their chemistry courses. When these topics come up in chemistry courses, their relevance to biology may go unmentioned.How did this disconnect happen? Why doesn't anyone seem to care? Wouldn't it be better for learning if students encountered topics in a logical order or encountered a reinforcing sequence in a coordinated curriculum? How can the problem be rectified?Modern biology is not the descriptive biology of old that was often associated with a march through organ systems and the kingdoms and phyla of life accompanied by memorization of more new words than a foreign language course [3]. Molecular biology is the centerpiece of modern biology and what many academic biologists want students to learn. Consequently, it usually comes first, and organismal and ecological topics come a semester later. A colleague told me that introductory biology used to have those semesters reversed, and they were part of a sophomore course offered after the prerequisite year of general chemistry. At some point, the course changed the order of topics and moved to the first year with the change of emphasis.

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Antibody imaging in breast cancer

Cited by 18 publications

References 25 publications

Tumor Detection and Visualization Using Cyanine Fluorochrome-Labeled Antibodies

Tumor Detection and Visualization Using Cyanine Fluorochrome-Labeled Antibodies

Scintimammography - Molecular Imaging: Value and New Perspectives with 99mTc(V)-DMSA

Commentary: Do biology and chemistry educators talk to each other?

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