Antibody Formation at Various Times After Previous Treatment of Mice With Endotoxin

The Action of Aluminium Hydroxide or Endotoxin on Natural Sheep Haemolysin Producing Cells in Rats

“…In agreement with Freedman's data [2,3], endotoxin increased the number of haemolysin-producing cells in the spleen even more markedly than it increased the total cell population. A fast return to normal levels was observed.…”

“…Bacterial endotoxins are known to stimulate natural haemo lysin production in the spleen [2,3], This raises the problem as to whether Al(OH)3 would similarly be capable of promoting natural haemolysin production in the rat spleen through a general effect. We have, therefore, studied the effect of endotoxin and of Al(OH)3 on the spleen weight and on the background level of plaque form ing cells (PFC) in the spleen.…”

Effect of an Interferon Inducer, 9-Methylstreptimidone, on Candida albicans Infection in Mice

“…Several well-known interferon inducers inhibit growth of spontaneous or transplanted tumors in mice (3,7,24), DNA synthesis in HeLa cells (21), and lymphocyte transformation induced by phytohemagglutinin (8) and enhance antibody formation in mice (1,2,16). These inducers inhibit growth of infectious agents other than viruses in vivo.…”

Cellular Kinetics of 19S and 7S Hemolysin Production in Mice under the Influence of Bacterial Endotoxins

“…18, 19, 20, 23]. F reedman et al [18][19][20] tested the adjuvancy of endotoxins 2 days after the primary immunization by determining the average numbers of 19S hemolysin-producing cells per 1 /5th spleen. An increased plaque number in the spleens of endotoxin-treated mice, as compared to control animals immunized with sheep red blood cells only, could be demonstrated.…”

“…It is still unknown whether this effect is produced by the lipopolysaccharide or by other structural components of B. pertussis. Endotoxins may likewise act as adjuvants in the primary immune response of various animal species to protein anti gens [26][27][28], By means of the direct antibody plaque technique [25] it has been shown that endotoxins produce both an accelerated develop ment of 19S hemolysin-producing spleen cells [9,15,18,19,20,23] and an increase in the number of pre-existing antibody-forming cells [3, 5, 9, …”