Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces
W. van der Wulp,
W. Luu,
M. E. Ressing
et al.
Abstract:Antibody-mediated delivery of immunogenic viral CD8
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T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. Multiple strategies for viral epitope delivery have been shown to be effective. So far, most of these have relied on a free C-terminus of the immunogenic epitope for extracellular delivery. Here, we demonstrate that antibody-epitope conjugates (AECs) with genetically fused epitopes to t… Show more
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