Antibody-Drug Conjugates in Urothelial Cancer: From Scientific Rationale to Clinical Development
Whi-An Kwon,
Seo-Yeon Lee,
Tae Jeong
et al.
Abstract:Antibody-drug conjugates (ADCs) have been a significant advancement in cancer therapy, particularly for urothelial cancer (UC). These innovative treatments, originally developed for hematological malignancies, use target-specific monoclonal antibodies linked to potent cytotoxic agents. This rational drug design efficiently delivers cancer cell-killing agents to cells expressing specific surface proteins, which are abundant in UC owing to their high antigen expression. UC is an ideal candidate for ADC therapy, … Show more
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