Antibody-Dependent Cell-Mediated Cytotoxicity to Target Cells Infected with Herpes Simplex Viruses

Shore, Steven L.; Melewicz, F. Michael; Milgrom, Henry; Nahmias, André J.

doi:10.1007/978-1-4684-3300-5_19

Cited by 54 publications

(96 citation statements)

References 13 publications

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“…Experimentally induced ADCC affords protection against the otherwise lethal herpes simplex virus (HSV) infection in neonatal mice [28]. In this context the functional adequacy of the human neonate cytotoxic response has been evaluated against target cells infected with HSV [29] Thus, lymphocytes from cord blood specimens were shown to have ADCC effector cell activity. Moreover, infants born to HSV+ mothers have detectable ADCC antibody levels in serum which last into the second half-year of life.…”

Section: Discussionmentioning

confidence: 99%

Antibody-dependent cellular cytotoxicity and neutralizing activity in sera of HIV-1-infected mothers and their children

Broliden

Sievers

Tovo

et al. 1993

Clinical and Experimental Immunology

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SUMMARYThe prognostic and protective role of antibodies mediating cellular cytotoxicity (ADCC) and neutralization was evaluated in sera of HIV-1-infected mothers and their consecutively followed children. The presence and titres of ADCC mediating and/or neutralizing antibodies in maternal sera did not predict HIV-1 infection in their respective children. No significant diflFerence in the sera from the children was seen when comparing the presence of neutralizing antibodies between the uninfected and infected children. Stratification of the infected group according to clinical status revealed differences. Only one of 24 AIDS patients had a high neutralizing titre against IIIB. Four patients had a very low titre and the remaining had no detectable neutralizing antibodies at all. In contrast, 10/17 infected non-AIDS children had neutralizing antibodies. Similarly, no significant difference was seen when comparing the presence of ADCC-mediating antibodies between the uninfected and the infected group of children. However, a significantly higher frequency of ADCC was seen in the seropositive non-AIDS children compared with the AIDS children. This study clearly shows that the presence of antibodies mediating ADCC and neutralization in infected children, 0-2 years old, is associated with a better clinical status and delayed disease progression.

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Section: Discussionmentioning

confidence: 99%

Antibody-dependent cellular cytotoxicity and neutralizing activity in sera of HIV-1-infected mothers and their children

Broliden

Sievers

Tovo

et al. 1993

Clinical and Experimental Immunology

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show abstract

“…Studies have revealed that ADCC activity in the human neonate may be blunted compared with the adult response. The ability of human cord blood mononuclear cells to mediate anti-HSV ADCC was shown to be significantly lower than that ofadult leukocytes (6,7). Although the neonatal ADCC response did not reach the magnitude of the adult, significant ADCC activity did occur.…”

Section: Resultsmentioning

confidence: 91%

“…As previously described in detail, ADCC was determined with HE strain HSV I-infected "Cr-labeled Chang liver target cells approximately 24 h after infection (6)(7)(8). Effector cells were added to target cells to a final volume of 0.2 mL in 96-well round-bottom microtiter plates (Coming Glass Works.…”

Section: Materials and Metliodsmentioning

confidence: 99%

Human Fetal Antibody-Dependent Cellular Cytotoxicity to Herpes Simplex Virus–Infected Cells

et al. 1994

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“…Specific cellular lysis of tumour cell is mainly performed by the classic T-cell immunity mechanism (Cerottini & Brunner, 1974) or the interaction of antibody with normal lymphoid cells, the latter being referred to as antibody-dependent cellular cytotoxicity (ADCC). The precise mechanism of ADCC is not understood, though it is known that the specificity of this imimunological reaction is determined by antibody bound to membrane-associated (Lamon et al, 1976;Shore et al, 1976a) and also against Durantez & Zighelboim, 1976), histocompatibility (Yust et al, 1974; A@~~~s s , Jeannet & Vassalli, 1976) or auto-antigens (Feldmann et al, 1976). It would appear that any cell in which a virus is replicating has alterecl membrane properties which make that cell susceptible to destruction by this mechanism (Shore et al, 1976b no activity in the direct, complementdependent assay.…”

Section: Discussionmentioning

confidence: 99%

Antibody-dependent cellular cytotoxicity against drug-induced antigens in L5178Y mouse lymphoma

Franco¹,

Veronese²,

Lévi³

et al. 1982

Br J Cancer

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In vivo treatment with antineoplastic compounds has been reported to lead to the expression of new antigenic specificities which were not detected on parental cells, and which were transmissible as a genetic character. The current study is concerned with antibody-dependent cellular cytotoxic (ADCC) activity in serum of syngeneic mice challenged with LY/DTIC cells, a subline of LY murine lymphoma, antigenically altered by the drug DTIC. LY/DTIC target cells coated with LY/DTIC-immune serum were specifically lysed by virgin lymphocytes. The genetic background of the effector cells, whether syngeneic, allogeneic or xenogeneic, did not produce significant differences in the percentage of target-cell lysis. ADCC activity was reduced when the immune serum was added directly to the incubation medium, without precoating. Although sera from individual animals exhibited different levels of ADCC activity, they nevertheless followed the general trend of the pooled sera. Peak activity of ADCC was obtained in the sera collected on Days 8 and 30 after LY/DTIC cell challenge. The ADCC activity elicited by LY/DTIC cells may contribute to the rejection of drug-altered tumour cells.

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Antibody-Dependent Cell-Mediated Cytotoxicity to Target Cells Infected with Herpes Simplex Viruses

Cited by 54 publications

References 13 publications

Antibody-dependent cellular cytotoxicity and neutralizing activity in sera of HIV-1-infected mothers and their children

Antibody-dependent cellular cytotoxicity and neutralizing activity in sera of HIV-1-infected mothers and their children

Human Fetal Antibody-Dependent Cellular Cytotoxicity to Herpes Simplex Virus–Infected Cells

Antibody-dependent cellular cytotoxicity against drug-induced antigens in L5178Y mouse lymphoma

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