Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Yang, Jaemoon; Lee, Choong Hwan; Park, Joseph; Seo, Sungbaek; Lim, Eun‐Kyung; Song, Yong Jin; Suh, Jin Suck; Yoon, Ho Geun; Huh, Yong Min; Haam, Seungjoo

doi:10.1039/b702538f

Cited by 178 publications

(135 citation statements)

References 16 publications

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“…[166][167][168] In a recent study, antibody-conjugated magnetic Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles with doxorubicin (DOX) were synthesized for the simultaneous targeted detection and treatment of breast cancer. [169] DOX and magnetic nanoparticles were incorporated into PLGA nanoparticles, with DOX serving as an anticancer drug and Fe 2 O 3 nanoparticles used as an imaging agent (Fig. 19).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Applications of Nanoparticles in Biology

2008

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Applications of Nanoparticles in Biology

2008

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“…In this study, the cytotoxicity of four different treatments (IDNP w/o laser treatment, AIDNP w/o laser treatment, IDNP w/ laser treatment and AIDNP w/ laser treatment) were investigated. Cells were seeded into a 96-well plate on the first day, and after overnight incubation they were exposed to different treatments The slow sustained release of DOX from targeted AIDNP and the biphasic behavior of the release profile observed in both AIDNP and IDNP are consistent with other literature reports as well (Yang 2007;Chittasupho 2009;. The two phases of DOX release correspond to an initial burst release, followed by a sustained slow release.…”

Section: Introductionsupporting

confidence: 71%

Multifunctional Nanoparticles for Theranostic Applications

Srinivasan¹

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iii DEDICATION I want to dedicate this dissertation to my husband Karthikeyan who lent never ending love and support throughout my journey in graduate school. He had immense belief in me that I would be able to make my way through graduate school. There was not a single day in four years of our married life that he complained about my absence. He always had more confidence in me than I did in myself. I regretted those times when I could not attend his call or wasn't able to hear to his problems during his difficult times. However, he was patient and was there for me, no matter what the circumstances were. He was always there when I was close to giving up, trying to make me understand the importance of what I was doing. I also want to dedicate my dissertation to my mother, father, motherin-law and father-in-law. I would like to thank them for all the support they extended during my journey. Multifunctional agents for the management of highly heterogeneous diseases, like cancer, are gaining increased interest with the intent of improving the diagnostics and therapy of cancer patients. These agents are also important because more than one treatment modality is typically used for cancer therapy in the clinic. Further, nanotechnology offers a platform where more than one agent can be combined to help provide improved cancer diagnosis and therapy. Near-infrared light-activatable phototherapeutic agents have great potential in vivo. Body tissues have minimum absorption in the near-infrared range.They also have been shown to enhance the cytotoxic effect of chemotherapeutic drugs when used in combination with them. We have, hence, investigated the potential of two multifunctional targeted nanoparticles for combined chemo-phototherapy (employing near-infrared light activable agent) and for understanding their underlying cellular responses. The first is employing polymeric Poly-lactic acid-co-glycolic acid (PLGA) nanoparticles with simultaneous incorporation of Indocyanine Green (ICG) (a nearinfrared light-activatable photothermal agent) and Doxorubicin (DOX) and surface conjugated with anti-Human Epithelial Receptor-2 (HER-2). The PLGA nanoparticles were subjected to two modes of hyperthermia, incubator and laser hyperthermia, to vii mimic whole-body and localized hyperthermia used clinically. These nanoparticles upon laser exposure showed a rapid heat shock protein 70 (HSP70) response in comparison to the cellular HSP70 response upon incubator hyperthermia exposure. However, 12h posttreatment, downregulation of HSP70, was observed, thus, causing cellular apoptosis or necrosis based on the degree of thermal insult. These targeted nanoparticles, simultaneously incorporating agents, suffer from the limitation of release of both the agents from the nanoparticles and the need to control their release for bringing in effective therapy. Therefore, the second multifunctional nanoparticle employing silver nanoparticles (AgNPs) conjugated with Doxorubicin was formulated. AgNP serve as a near-infrared activatable agent itself, o...

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“…This nanocomposite has been employed for the concurrent targeted iagnosis and management of breast cancer [76] . Recently, multimodal nano-materials have been exploited for immediate diagnosis and therapy.…”

Section: Mri and Cancer Therapymentioning

confidence: 99%

Engineered magnetic core shell nanoprobes: Synthesis and applications to cancer imaging and therapeutics

Mandal

Chaudhuri

2016

WJBC

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Magnetic core shell nanoparticles are composed of a highly magnetic core material surrounded by a thin shell of desired drug, polymer or metal oxide. These magnetic core shell nanoparticles have a wide range of applications in biomedical research, more specifically in tissue imaging, drug delivery and therapeutics. The present review discusses the up-to-date knowledge on the various procedures for synthesis of magnetic core shell nanoparticles along with their applications in cancer imaging, drug delivery and hyperthermia or cancer therapeutics. Literature in this area shows that magnetic core shell nanoparticle-based imaging, drug targeting and therapy through hyperthermia can potentially be a powerful tool for the advanced diagnosis and treatment of various cancers.

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Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Cited by 178 publications

References 16 publications

Applications of Nanoparticles in Biology

Applications of Nanoparticles in Biology

Multifunctional Nanoparticles for Theranostic Applications

Engineered magnetic core shell nanoprobes: Synthesis and applications to cancer imaging and therapeutics

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