Antibody Concentrations Decrease 14-Fold in Children With Celiac Disease on a Gluten-Free Diet but Remain High at 3 Months

Petroff, David; Je, Wolf; Richter, Thomas; Auth, Marcus K.H.; Uhlig, Holm H.; Laaß, Martin W.; Lauenstein, Peter; Krahl, Andreas; Händel, Norman; Laffolie, Jan de; Hauer, Almuthe; Heiduk, Matthias; Flemming, Gunter; Schmidt, Antje; Hasenclever, Dirk; Mothes, Thomas

doi:10.1016/j.cgh.2018.04.008

Cited by 12 publications

(12 citation statements)

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“…Guz-Mark et al reported 36% of patients as never fully normalising 11. Petroff et al described the response to a GFD in nearly 350 patients over a 3-month period after diagnosis, with over 83.8% of the patients failing to have a normalised TTG in this time and over a quarter of patients remaining >10 times the upper limit of normal 12. Gidrewicz et al stratified the patients by TTG titre levels as a proportion of normal at diagnosis, finding that those with the highest levels at diagnosis were significantly more likely to have an abnormal TTG at 12 months compared with those in the lowest group, 79.7% vs 36% 13.…”

Section: Discussionmentioning

confidence: 99%

Time to normalisation of tissue transglutaminase in paediatric coeliac disease is dependent on initial titre and half of patients will normalise within 12 months

et al. 2022

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BackgroundCoeliac disease (CD) is common. Response to a gluten-free diet is assessed through serial measurement of tissue transglutaminase (TTG) antibody titre. However, the relationship of TTG titres to symptoms and the speed of normalisation is poorly understood.MethodsPatients seen in 2020, and under follow-up in the Southampton CD clinic, had blood results, growth measures and symptom data collated. Time to normalisation, predictors of normalisation and relationship of TTG to growth/symptoms were assessed.Results57 patients were included. All had TTG results from the time of diagnosis and follow-up. All families reported dietary compliance.Median TTG at diagnosis was 100 μ/L (range 0.3–4360), 94.7% of the patients had symptoms compatible with CD. At 6–12 months after diagnosis, the median TTG was 3.8 μ/mL (range 0.3–133). In terms of response, 29 of the 57 patients (50.9%) had a TTG below 4 μ/mL (upper normal limit). A further 25 patients (43.9%) had a TTG<10 times the upper limit of normal. Ten patients (17.5%) had a persistently high TTG (median=8.55 μ/mL, range 4.1–303) after >12 months.TTG at diagnosis was correlated with TTG at 6–12 months, β=0.542, p=0.000016. Patients with TTG<10 times the upper limit of normal at diagnosis group were more likely to have normalised at 6–12 months compared with >10 times normal (85% vs 32.4%, p=0.0015). TTG titres did not correlate with growth measures (Z-scores) at diagnosis or at follow-up.ConclusionsNormalisation of TTG levels occurs within 6–12 months for around half of patients. Higher TTG levels at diagnosis take longer to normalise. The role of compliance is unclear.

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Section: Discussionmentioning

confidence: 99%

Time to normalisation of tissue transglutaminase in paediatric coeliac disease is dependent on initial titre and half of patients will normalise within 12 months

et al. 2022

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“…However, the imprecision of the autoantibody assays that we report here, is not prejudicial for patient care according to the different clinical guidelines. Though variable according to the different autoimmune diseases, such as in coeliac disease, lupus or vasculitis, [25][26][27][28] the significant clinical variations, i.e levels variation that have an impact on the patients diagnostic, prognosis or management, are usually higher than the imprecision of the assays. However, it would be useful for the physicians to be informed about the measurement uncertainty inherent to each autoantibody assay.…”

Section: Discussionmentioning

confidence: 99%

Precision of autoantibody assays in clinical diagnostic laboratories: What is the reality?

Senant

Musset

Chyderiotis

et al. 2020

Clinical Biochemistry

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“…The results showed a significant decrease in the measurement of both urea and uric acid in healthy subjects whose age group ranged between (2-12) years compared with healthy subjects whose age group ranged between (13-25) years, and the presence of a significant increase in the measurement of both Urea and uric acid in healthy subjects whose age group ranged between (13-25) years compared with healthy subjects whose age group ranged between (2-12) years. The results in Table (2) showed that there was a significant decrease in the measurement of both uric acid and glucose, and there was no significant difference in the measurement of creatinine and urea in patients who eating gluten and whose age group ranged between (2-12) years compared with patients who eating gluten and whose age group ranged between (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) years with a probability level (p ≤ 0.05). The results in Table (2) showed that there was no significant difference in the measurement of creatinine, urea, uric acid and glucose in patients who abstained from eating gluten and whose age group ranged between (2-12) years compared with patients who abstained from eating gluten in the age group Between (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) years at a probability level (p ≤ 0.05).…”

Section: Resultmentioning

confidence: 98%

“…The results in Table (2) showed that there was a significant decrease in the measurement of both uric acid and glucose, and there was no significant difference in the measurement of creatinine and urea in patients who eating gluten and whose age group ranged between (2-12) years compared with patients who eating gluten and whose age group ranged between (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) years with a probability level (p ≤ 0.05). The results in Table (2) showed that there was no significant difference in the measurement of creatinine, urea, uric acid and glucose in patients who abstained from eating gluten and whose age group ranged between (2-12) years compared with patients who abstained from eating gluten in the age group Between (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) years at a probability level (p ≤ 0.05).…”

Section: Resultmentioning

confidence: 98%

A Study of Some Biochemical Indicators of Kidney Function and Estimation of Some Elements Concentration in the Blood Serum of Patients With Celiac Disease

ATARBASHI¹,

AL-DAGESTANI²

2022

MINAR Journal

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Celiac disease is a long-term autoimmune and digestive disorder that damages small intestine. The current study aimed to estimate some important enzymatic and biochemical variables for kidney functions in patients who eat gluten and abstain from it, compare them with healthy ones, see the usefulness of the GFD “Gluten free diet” to improve the health status of patients, and find biomarkers that contribute to the early diagnosis of celiac disease. The current study was conducted in Nineveh Governorate on patients who came to Al-Salam, Ibn Sina and Al-Khansa Hospital, as well as some private laboratories, as well as some patients from the students of Mosul University, the Technical Institute, and Al-Jada’a and Salamiyah camps after accurate diagnosis by specialist Doctors . 183 blood serum samples were collected for people of both sexes, aged between (2-25) years,. The samples were distributed into three groups, the group of patients who take gluten, including (62) samples (31 males and 31 females), and the group of patients who abstain from eating gluten, which includes (61) samples (31 males and 30 females), as well as the healthy group (control). It includes (60) samples (30 males and 30 females) The results of the current study showed a significant increase in tissue transglutaminase tTG-IgA enzyme for patients taking gluten compared to healthy subjects and no significant difference in enzyme activity in GFD patients compared to healthy subjects at a probability level (p ≤ 0.05). The results also showed that there was no significant difference in the measurement of creatinine, uric acid and glucose in patients who eat gluten as well as for gluten free diet GFD patients, and a significant increase in the measurement of urea in patients who take gluten compared with the healthy group , and no significant difference in the measurement of urea for GFD patients compared with control. The results also showed a significant decrease in Fe+2, Cu+2, Ca+2, and Zn+2 in patients who take gluten, as well as for GFD patients, compared with healthy subjects at a probability level (p ≤ 0.05). In conclusion monitoring of these biochemical markers is important in diagnosis and follow-up of celiac patients.

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Antibody Concentrations Decrease 14-Fold in Children With Celiac Disease on a Gluten-Free Diet but Remain High at 3 Months

Cited by 12 publications

References 25 publications

Time to normalisation of tissue transglutaminase in paediatric coeliac disease is dependent on initial titre and half of patients will normalise within 12 months

Time to normalisation of tissue transglutaminase in paediatric coeliac disease is dependent on initial titre and half of patients will normalise within 12 months

Precision of autoantibody assays in clinical diagnostic laboratories: What is the reality?

A Study of Some Biochemical Indicators of Kidney Function and Estimation of Some Elements Concentration in the Blood Serum of Patients With Celiac Disease

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