Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome

Brilot, Fabienne; Merheb, Vera; Ding, A.; Murphy, Tanya K.; Dale, Russell C.

doi:10.1212/wnl.0b013e3182181090

Cited by 89 publications

(66 citation statements)

References 22 publications

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“…These authors scored visually this binding using immunofluorescence. Conversely, when IgG cells surface binding to live differentiated neurons and to a nonneuronal control cell line was quantitatively measured with more accuracy using flow cytometry, no significant difference in IgG cell surface binding was detected between sera from 12 patients with PANDAS, 11 with TS, and two groups of control subjects [38]. The small sample size in this more recent flow cytometry work does not allow, however, to draw firm conclusions on the true frequency of autoantibodies in TS.…”

Section: Autoimmunitymentioning

confidence: 68%

Immune Dysfunction in Tourette Syndrome

Elamin

Edwards

Martino

2013

Behavioural Neurology

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Abstract.The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. A similar link has been proposed also for Tourette syndrome (TS), a complex, multifactorial disorder, in which the interplay between genetic, environmental, hormonal and immunological factors might be relevant. Lymphocyte subpopulation analysis in TS suggests a possible systemic activation of several T-and B-cell subtypes, whereas the observed decreased numbers of T regulatory lymphocytes might predispose to autoimmunity. Genes related to both cell-and antibodymediated immune responses may be over-expressed at specific ages in youngsters with TS. Data from cytokine measurements and transcriptomics profiles in TS patients are coherent with the systemic immune activation detected by studies on lymphocyte subpopulations. Moreover, TS patients have exhibited IgG3 and IgA dysgammaglobulinemia, which might predispose to recurrent infections and autoimmunity. To date, the association between TS and autoantibodies has not been demonstrated. Interestingly, however, there is a higher degree of maternal family history of autoimmune diseases among TS patients. Finally, TS patients could be prone to allergic illnesses (asthma, atopic dermatitis, rhinitis, conjunctivitis), but more work is needed in this area.

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Section: Autoimmunitymentioning

confidence: 68%

Immune Dysfunction in Tourette Syndrome

Elamin

Edwards

Martino

2013

Behavioural Neurology

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“…PANDAS exhibits immunological similarities to Sydenham's chorea (SC), a classic infection-triggered autoimmune disorder that also presents with a high degree of OCD comorbidity (Swedo et al 1989). However, unlike SC, definitive evidence for autoantibody-mediated reactions in PANDAS has been less conclusive (Brilot et al 2011;Morris-Berry et al 2013). A newer iteration of acute-onset neuropsychiatric symptoms not dependent upon a GAS association is termed ''pediatric acute-onset neuropsychiatric syndrome'' (PANS) (Swedo et al 2012).…”

Section: 4mentioning

confidence: 99%

PANDAS and Comorbid Kleine–Levin Syndrome

Gerardi

Casadonte

Patel

et al. 2015

Journal of Child and Adolescent Psychopharmacology

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“…Buna rağmen bazı çalışmalarda, PANDAS hastalarında antinöral antikor seviyelerinde ya yükselme saptayamamış ya da bu yükselmenin PANDAS olmayan OKB olan çocuklardan ayrımını sağlayamamıştır 12,13 . Otoantikor teorisini desteklemeyen ilginç bir makalede ise, PANDAS ve Sydenham koresi hastalarından alınan spesifik antinöral antikorların nöral hücre kültürlerindeki etkisi incelenmiş ve Sydenham koreli hastaların antikorları nöral hücrelere bağlanırken, PANDAS'lı hastaların antikorları bağlanmamıştır 14 .…”

Section: Patofizyolojiunclassified

Streptokok Enfeksiyonu İle İlişkili Pediatrik Otoimmün Nöropsikiyatrik Hastalıklar: Kulak Burun Boğaz Hekiminin Yeri

Kara¹,

Özdemir²

2015

Arşiv Kaynak Tarama Dergisi

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Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, refers to a disorder in children that manifest symptoms of obsessive-compulsive disorder and/or tic disorders associated with acute exacerbations. Although autoimmune responses following infections with streptococcus have been hypothesized to be responsible, there are still controversies about the pathophysiology and treatment. In this article, the treatment methods of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and the role of otolaryngologist were discussed. Key words: PANDAS, treatment, tonsillectomy, obsessive-compulsive disorder ÖZET Streptokok enfeksiyonu ile ilişkili pediatrik otoimmün nöropsikiyatrik hastalıklar, akut alevlenmelerle seyreden ve etkilenen çocuklarda obsesif kompulsif bozukluklar ve/veya tiklerle seyreden bir hastalıktır. Streptokok enfeksiyonu sonrası oluşan otoimmün yanıtın hastalıktan sorumlu olduğu düşünülse de, patofizyoloji ve tedavi üzerindeki tartışmalar halen devam etmektedir. Bu makalede, streptokok enfeksiyonu ile ilişkili pediatrik otoimmün nöropsikiyatrik hastalıkların tedavisi ve tedavide kulak burun boğaz hekiminin yeri tartışılacaktır.

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Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome

Cited by 89 publications

References 22 publications

Immune Dysfunction in Tourette Syndrome

Immune Dysfunction in Tourette Syndrome

PANDAS and Comorbid Kleine–Levin Syndrome

Streptokok Enfeksiyonu İle İlişkili Pediatrik Otoimmün Nöropsikiyatrik Hastalıklar: Kulak Burun Boğaz Hekiminin Yeri

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