Antibody Based Delivery of Toxins and Other Active Molecules for Cancer Therapy

Polito, Letizia

doi:10.3390/biomedicines10020267

Biomedicines

2022

DOI: 10.3390/biomedicines10020267

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Antibody Based Delivery of Toxins and Other Active Molecules for Cancer Therapy

Letizia Polito

Abstract: The use of radio- and chemotherapeutic agents in cancer therapy have demonstrated evident antitumor effects, but also limitations (remarkable side-effects due to lack of selectivity for tumor cells, development of drug resistance, and occurrence of secondary malignancies) [...]

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2023

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New Insights on Pseudomonas Aeruginosa Exotoxin A-based Immunotoxins in Targeted Cancer Therapeutic Delivery

et al. 2023

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Pseudomonas aeruginosa exotoxin A-based immunotoxins (PE-ITs) are fusion proteins that harness targeting and toxin moieties. Structural optimizations in PE and targeting moieties were implemented to lower their immunogenicity and alleviate undesirable side effects. PE moiety was engineered to lack its cell-binding domain and T cell epitope regions, whereas single chain (scFv) and disulfide Fv portions (dsFv), nanobodies, and monobodies were utilized as targeting moieties. This review discusses applications of PE-ITs on different types of cancer, structural optimizations to reduce PE-ITs drawbacks, and recent modifications applied for efficient therapeutic delivery. Finally, we draw attention to the possibility of combining radiotherapy, radionuclides, and RGDs with PE-IT to improve overall response rates of IT-based treatments and reduce cancer cell resistance.

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New Insights on Pseudomonas Aeruginosa Exotoxin A-based Immunotoxins in Targeted Cancer Therapeutic Delivery

et al. 2023

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Antibody Based Delivery of Toxins and Other Active Molecules for Cancer Therapy

Abstract: The use of radio- and chemotherapeutic agents in cancer therapy have demonstrated evident antitumor effects, but also limitations (remarkable side-effects due to lack of selectivity for tumor cells, development of drug resistance, and occurrence of secondary malignancies) [...]

Cited by 1 publication

References 17 publications

New Insights on Pseudomonas Aeruginosa Exotoxin A-based Immunotoxins in Targeted Cancer Therapeutic Delivery

New Insights on Pseudomonas Aeruginosa Exotoxin A-based Immunotoxins in Targeted Cancer Therapeutic Delivery

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