2011
DOI: 10.1016/j.clim.2010.12.013
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Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART

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Cited by 16 publications
(9 citation statements)
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“…In HIV-HCV co-infected patients who have HF following initiation of cART, serum markers of T-cell activation (sCD26, sCD30), and the chemokine CXCL10 increased in some (270) but not all studies (271). We found that subjects with HF after cART had a higher frequency of IFN-γ-producing T cells targeting non-structural HCV peptides, as well as higher levels of anti-HCV antibodies (271) (Fig.…”
Section: Hepatitis C Virus Co-infectionmentioning
confidence: 99%
“…In HIV-HCV co-infected patients who have HF following initiation of cART, serum markers of T-cell activation (sCD26, sCD30), and the chemokine CXCL10 increased in some (270) but not all studies (271). We found that subjects with HF after cART had a higher frequency of IFN-γ-producing T cells targeting non-structural HCV peptides, as well as higher levels of anti-HCV antibodies (271) (Fig.…”
Section: Hepatitis C Virus Co-infectionmentioning
confidence: 99%
“…In the setting of viral hepatitis HAART-driven immune reconstitution may restore immune responses to HCV antigens. This mechanism of transaminase elevation is shared by all antiretrovirals as it is the result of an effective HAART [14]. The clinical presentation consists of transminase elevation, whereas an abrupt increase of CD4 takes place after HAART initiation from a low baseline CD4 cell count and which spontaneously resolves thereafter [15][16][17].…”
Section: Immune Reconstitutionmentioning
confidence: 97%
“…As suggested for sCD30, the concentration of these soluble proteins has also been considered to serve as a surrogate marker for T cell activation [79], and if true, then this would be very attractive from both analytical (commercial kits available) and pre-analytical points of view (sample stability). However, as mentioned above, the specificity of these molecules for a particular type of cell is limited because they can have various origins.…”
Section: Accepted Manuscriptmentioning
confidence: 99%