Antibodies: Will Their Star Continue to Rise?

Lake, Francesca

doi:10.2144/btn-2019-0045

Cited by 2 publications

(2 citation statements)

References 10 publications

(13 reference statements)

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“…While this new understanding of human biology should go some way to pushing science forward, antibody-based research has in the past been plagued by problems. Last year we covered antibodies and their reproducibility crisis in detail [9]. At that point, we reported on work from the HPA that had suggested that of 5000 commercial antibodies tested, over 50% were not useful for the proposed application, which is somewhat damning.…”

Section: Revisiting the Reproducibility Questionmentioning

confidence: 99%

Profiling a Human: The Role of Antibodies

Lake

2020

BioTechniques

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Section: Revisiting the Reproducibility Questionmentioning

confidence: 99%

Profiling a Human: The Role of Antibodies

Lake

2020

BioTechniques

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“…2 engineering. However, the current administration of antibody therapeutics is restricted to the invasive parenteral route, which presents limitations such as increased risks of systemic toxicity like cytokine release syndrome [13,14].…”

Section: Introductionmentioning

confidence: 99%

Nanobodies as Spray and Aerosol Particles: A Breakthrough in Treating Respiratory Viral Infections

Mustafa,

Mohammed

2023

Preprint

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Respiratory viral infections, including influenza, respiratory syncytial virus (RSV), and, more recently, the coronavirus disease 2019 (COVID-19) pandemic, continue to pose significant global health threats. Conventional treatments for these infections often face challenges such as limited efficacy, the emergence of drug-resistant strains, and the requirement for frequent administration. In recent years, nanobodies have emerged as a promising class of therapeutic agents due to their unique properties, including small size, high stability, and specific binding capabilities. This mini-review article focuses on the application of nanobodies as spray and aerosol particles for the treatment of respiratory viral infections. Furthermore, we highlight the remarkable efficacy of nanobodies in preclinical and clinical studies against respiratory viruses, including their ability to neutralize viral particles, inhibit viral replication, and modulate the host immune response. We discuss the potential advantages of using nanobodies as inhalable formulations, including their improved delivery to the respiratory tract, enhanced stability in aerosol form, and reduced systemic side effects. Additionally, we explore the various strategies employed to engineer nanobodies for optimal aerosol delivery, such as conjugation to carrier particles or formulation as dry powders. We also examine the potential challenges and limitations associated with the development of nanobody-based aerosol therapies, including production scalability, cost-effectiveness, and regulatory considerations.

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Antibodies: Will Their Star Continue to Rise?

Abstract: Antibodies are having a huge impact in basic and translational research, but they are also in crisis. Francesca Lake investigates.

Cited by 2 publications

References 10 publications

Profiling a Human: The Role of Antibodies

Profiling a Human: The Role of Antibodies

Nanobodies as Spray and Aerosol Particles: A Breakthrough in Treating Respiratory Viral Infections

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