Antibodies to trypsinogen activation peptides recognize both Ca2+-dependent and Ca2+— independent epitopes

Severe acute pancreatitis is related to increased early urinary levels of the activation peptide of pancreatic phospholipase A2

“…Moreover, this significant increase in urinary PROP is only transient. The immediate rise in the level of urinary TAP (approximately sevenfold in severe cases) [4,5,20] is not sustained beyond 96 h after the onset of symptoms [5]. This supports the hypothesis that trypsinogen is the key enzyme to be activated at the onset of acute pancreatitis, but that continuation of the disease and the development of systemic organ dysfunction are relatively independent of further pancreatic enzyme activation.…”

“…A number of clinical and experimental studies have substantiated the idea of predicting the severity of acute pancreatitis by measuring the TAP levels [4,5,[20][21][22]. Trypsin, once inappropriately activated within pancreatic acinar cells, is believed to activate other inactive zymogens including proPLA 2 -I [6,7,23].…”