Antibodies to SARS-CoV-2 and risk of future sickness

Dillner, Joakim; Elfström, Miriam; Blomqvist, Jonas; Eklund, Carina; Lagheden, Camilla; Kleppe, Sara Nordqvist; Hellström, Cecilia; Olofsson, Jennie; Andersson, Eni; Falk, Alexander; Bergström, Sofia; Hultin, Emilie; Pin, Elisa; Månberg, Anna; Nilsson, Peter; Hedhammar, My; Hober, Sophia; Mattsson, Johan; Mühr, Laila Sara Arroyo; Lundgren, Kalle Conneryd

doi:10.1101/2020.09.14.20194308

Cited by 4 publications

(9 citation statements)

References 11 publications

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“…This study found a prevalence of 18% of IgG antibodies against SARS-CoV-2 among HCWs in a large cohort of HCWs from Stockholm, Sweden sampled during the later phases of the first wave of the epidemic. The seroprevalence was similar to the 19% reported among 2149 HCWs at Danderyd Hospital, a hospital of equivalent size in the Stockholm area [3], whereas Karolinska university Hospital demonstrated a lower seroprevalence of 12% among 12,928 HCWs [9]. Globally, seroprevalences among HCWs have ranged from 0 to 45.3% [6].…”

Section: Discussionsupporting

confidence: 73%

Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care

Klevebro

Bahram

Elfström

et al. 2021

Scand J Public Health

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Aim: We aimed to assess prevalence of IgG antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and factors associated with seropositivity in a large cohort of healthcare workers (HCWs). Methods: From 11 May until 11 June 2020, 3981 HCWs at a large Swedish emergency care hospital provided serum samples and questionnaire data. Presence of IgG antibodies to SARS-CoV-2 was measured as an indicator of SARS-CoV-2 exposure. Results: The total seroprevalence was 18% and increased during the study period. Among the seropositive HCWs, 11% had been entirely asymptomatic. Participants who worked with COVID-19 patients had higher odds for seropositivity: adjusted odds ratio 1.96 (95% confidence intervals 1.59–2.42). HCWs from three of the departments managing COVID-19 patients had significantly higher seroprevalences, whereas the prevalence among HCWs from the intensive care unit (also managing COVID-19 patients) was significantly lower. Conclusions: HCWs in contact with SARS-CoV-2 infected patients had a variable, but on average higher, likelihood for SARS-CoV-2 infections.

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Section: Discussionsupporting

confidence: 73%

Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care

Klevebro

Bahram

Elfström

et al. 2021

Scand J Public Health

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“…The seroprevalence was similar to the 19.1% reported among 2,149 HCWs at Danderyd Hospital, a hospital of equivalent size in the Stockholm area, 3 whereas Karolinska University Hospital demonstrated a lower seroprevalence of 11.5% among 12,928 HCWs. 9 Globally, seroprevalences among HCWs have ranged from 0% to 45.3%. 6 Residents in Stockholm had a seroprevalence of around 10% during the time of our study.…”

Section: Discussionmentioning

confidence: 99%

Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care

Klevebro

Bahram

Elfström

et al. 2021

Preprint

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AimWe aimed to assess the risk for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in a large cohort of healthcare workers (HCWs).MethodsFrom May 11 until June 11, 2020, 3,981 HCWs at a large Swedish Emergency Care hospital provided serum samples and questionnaire data. Exposure was measured by assaying IgG antibodies to SARS-CoV-2.ResultsThe total seroprevalence was 17.7% and increased during the study period. Among the seropositive HCWs, 10.5% had been entirely asymptomatic. Participants who worked with COVID-19 patients had higher odds for seropositivity: ORadj 1.96 (95% CI 1.59 – 2.42). HCWs from three of the departments managing COVID-19 patients had significantly higher seroprevalences, whereas the prevalence among HCWs from the Intensive Care Unit (also managing COVID-19 patients) was significantly lower.ConclusionHCWs in contact with SARS-CoV-2 infected patients had a variable, but on average higher, likelihood for SARS-CoV-2 infections.

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“…By comparison, the simultaneously enrolled reference group of employees without patient contact (n=3671) had a 9.7% seropositivity rate when tested by exactly the same serum test (OR for seropositivity when employed in home care services compared to the reference group: 2.3 (95% CI 1.8-3.1), p<0.0001, [12]).…”

Section: Resultsmentioning

confidence: 99%

“…As described in a parallel paper [12], we assembled a reference group of 3671 hospital employees that had no patient contact whatsoever. There were simultaneously enrolled at the Karolinska University hospital, also in Stockholm, Sweden.…”

Section: Methodsmentioning

confidence: 99%

“…The Hospital employees without patient contact were, for example, working with administration, economy, information technology, engineering, research & innovation, or at the hospital laboratories. As hospital employees are very motivated to participate (92% participated in the parallel study) [12] we considered that use of hospital employees without patient contact would be a rapid strategy to obtain a large reference group with minimum selection bias because of non-participation that could be considered as approximately representative of the underlying degree of SARS-CoV-2 exposure in the region.…”

Section: Methodsmentioning

confidence: 99%

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SARS-CoV-2 infections among personnel providing home care services for the elderly in Stockholm, Sweden

Hassan

Seigerud²,

Mühr

et al. 2020

Preprint

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BackgroundIn March 2020, Stockholm, Sweden was hit by a severe outbreak of SARS-CoV-2. Four weeks later, a systematic study of testing for past or present infections among healthcare workers in the region was launched. Only a minority of COVID-19 related deaths occurred at hospitals and the study was therefore extended to employees in companies providing home care services for the elderly.MethodsFive companies offered participation to 438 employees at work and 405 employees (92.5%) were enrolled. Serum samples were analyzed for IgG to SARS-CoV-2 and throat swabs were tested by for the SARS-CoV-2 virus by PCR.ResultsAmong home care employees, 20.1% (81/403) were seropositive, about twice as many as in a simultaneously enrolled reference population (healthcare workers entirely without patient contact, n=3,671; 9.7% seropositivity). Only 13/379 employees (3.4%) had evidence of a current infection (PCR positivity). Among these, 5 were also seropositive (a sign of past infection or lingering infection after symptoms have resolved) and 3 were positive with only low amounts of virus. The combination of high amounts of virus and no antibodies, a characteristic for pre-symptomatic COVID-19, was thus present only in 5 employees (1.3%).ConclusionsPersonnel providing home service for the elderly appear to be a risk group for SARS-CoV-2 infection. Employees likely to be pre-symptomatic for COVID-19 can be readily identified by screening. Increased attention for protection of employees as well as of the elderly they serve is warranted.

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Antibodies to SARS-CoV-2 and risk of future sickness

Cited by 4 publications

References 11 publications

Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care

Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care

Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care

SARS-CoV-2 infections among personnel providing home care services for the elderly in Stockholm, Sweden

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