Antibodies to Mycoplasma in Sera of Leukemic Patients.

Murphy, William H.; Ertel, Inta J.; Bullis, C.; Zarafonetis, Chris J. D.

doi:10.3181/00379727-124-31744

Cited by 9 publications

(2 citation statements)

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“…e investigation of this oncogenic potential has been started from the middle of the 1960s, when several studies reported the detection of some human Mycoplasma species or their antibodies in patients suffering from leukemia [51][52][53][54][55][56][57]. Although these studies did not provide causal evidence for the involvement of mycoplasmas in cancer, they represented an opportunity for further investigations.…”

Section: Mycoplasmas: Atypical Tiny Microorganisms Capable Of Causing Serious Troublesmentioning

confidence: 99%

The Relationship between Mycoplasmas and Cancer: Is It Fact or Fiction ? Narrative Review and Update on the Situation

Yacoub

Abdul-Wahab

Alshyarba

et al. 2021

Journal of Oncology

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More than one million new cancer cases occur worldwide every year. Although many clinical trials are applied and recent diagnostic tools are employed, curing cancer disease is still a great challenge for mankind. Heredity and epigenetics are the main risk factors often related to cancer. Although, the infectious etiological role in carcinogenesis was also theorized. By establishing chronic infection and inflammation in their hosts, several microorganisms were suggested to cause cell transformation. Of these suspicious microorganisms, mycoplasmas were well regarded because of their intimate parasitism with host cells, as well as their silent and insidious role during infections. This assumption has opened many questions about the real role played by mycoplasmas in oncogenesis. Herein, we presented a sum up of many studies among the hundreds which had addressed the Mycoplasma-cancer topic over the past 50 years. Research studies in this field have first started by approving the mycoplasmas malignancy potential. Indeed, using animal models and in vitro experiments in various cell lines from human and other mammalians, many mycoplasmas were proven to cause varied modifications leading to cell transformation. Moreover, many studies have looked upon the Mycoplasma-cancer subject from an epidemiological point of view. Diverse techniques were used to assess the mycoplasmas prevalence in patients with cancer from different countries. Not less than 10 Mycoplasma species were detected in the context of at least 15 cancer types affecting the brain, the breast, the lymphatic system, and different organs in the genitourinary, respiratory, gastrointestinal, and urinary tracts. Based on these revelations, one should concede that detection of mycoplasmas often linked to ‘‘wolf in sheep’s clothing’’ is not a coincidence and might have a role in cancer. Thorough investigations are needed to better elucidate this role. This would have a substantial impact on the improvement of cancer diagnosis and its prevention.

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Section: Mycoplasmas: Atypical Tiny Microorganisms Capable Of Causing Serious Troublesmentioning

confidence: 99%

The Relationship between Mycoplasmas and Cancer: Is It Fact or Fiction ? Narrative Review and Update on the Situation

Yacoub

Abdul-Wahab

Alshyarba

et al. 2021

Journal of Oncology

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show abstract

“…Αυτό δείχνει, οτι ή πρωτείνη τής μυκοπλασματικής μεμβράνης παίζει επίσης κάποιο ρόλο στο μηχανισμό τής προσκόλλησης (Thomas 1969 (Stokes 1955, 1959, Shepard 1956, Ford καί Duvernet 1963, Δουμπόγιας 1974, Taylor Robinson 1977, ή οξεία αιμορραγική κυστίτιδα (Berg et al 1957), ή οξεία καί χρόνια προστατίτιδα (Marx καί Hofstetter 1975), ή βαλανίτιδα (Ruiter καί Wentholt 1952), τα παραουρηθρικά αποστήματα (Deines et al 1948), ή οξεία σαλπιγγίτιδα καί τα αποστήματα τών σαλπίγγων καί τής πυέλου (Russell καί Fallon 1970, Solomon et al 1970, 1973, Mardh et al 1975, οί σηψαιμικές καταστάσεις μετά έκτρωση ή τοκετό (Harwich et al 1967, Jones 1967, Tully καί Smith 1968, Solomon et al 1973, οί αυτόματες εκτρώσεις (Caspi et al 1972, Vassalos et al 1972, το πολύμορφο ερύθημα (Gordon καί Lyell, 1970). Πολλές εργασίες αναφέρονται σε απομόνωση μυκοπλασμάτων άπα ανθρώπινο καρκινικό υλικό (Hayflick καί Stanbridge 1967, Barile 1967, Murphy 1967. Τελευταίες εργασίες υπαινίσσονται ότι το Μ. pneumoniae μπορεί να προκαλέσει νόσους του κεντρικού νευρικού συστήματος.…”

Section: ' επίδραση των μυκοπλασμάτων στα κύτταρα τοΰ ξενιστήunclassified