Antibodies toChlamydia trachomatisin serum and peritoneal fluid of women with endometriosis

Abstract

The specifics of inflammation created by infection with Chlamydia trachomatis could be favourable to the genesis of endometriosis. To investigate this hypothesis, we studied the association between Chlamydia trachomatis specific IgG and IgA antibodies in serum and the peritoneal fluid of 51 women undergoing laparoscopic surgery. There was no significant difference between women with and without endometriosis with respect to the incidence of IgG and IgA in serum or the peritoneal fluid. The results of our preliminary study did not show any significant link between past infection with Chlamydia trachomatis and the presence of endometriosis.

Assessment of Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycobacterium tuberculosis infections in women undergoing laparoscopy: the role of peritoneal fluid sampling

“…Despite the paucity of studies which were the object of our qualitative synthesis, the 20-year temporal interval between the first study (published in 1996) and our study (published presently) denotes either a renewed or always alive interest to this topic. It is relevant that, in almost all of these studies (6,8,12,23), the clinical samples used were peritoneal or tubal fluids/tissues, which were tested alone (12; this study) and in combination with cervical (6) and serum (6,8) samples or with tissue samples from ovarian and endometrium lesions (23). Consistent with these studies, we found that endometriosis was not associated with peritoneal CT infection in women undergoing either a fertility or non-fertility diagnostic workup.…”

Chlamydial Pgp3 Seropositivity and Population-Attributable Fraction Among Women With Tubal Factor Infertility

“…Endometriosis has been associated with infertility and obstruction of the fallopian tubes possibly due to anatomical distortions due to adhesions and fibrosis (21,22). Although chlamydial infection has been linked with endometriosis in one paper, the data for this association are poor and the mechanism for this association is not clear (23,24). Because we did not see a significant association between Pgp3 serology and TFI among women with endometriosis, we might speculate that among these women, the association between chlamydia and TFI may be obscured by an association between endometriosis and TFI.…”

The Correlation between Chlamydia Trachomatis and Female Infertility: A Systematic Review

“… 31 32 33 This immunological alteration can also explain the mild endometriosis in patients that previously presented CT infection, once the immunological imbalance caused might lead to the impossibility of an adequate action of the lymphocytes, allowing the maintenance of viable endometrial cells in the pelvic environment. 34 Thus, the CT infection and its associated mechanical and biochemical damage, as well as endometriosis, induce a modification in the female reproductive tract's environment, which becomes hostile to the gametes.…”