Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevance

Cl, Mendenhall; Seeff, L. B.; Am, Diehl; Sj, Ghosn; Sw, French; Ps, Gartside; Sd, Rouster; Buskell‐Bales, Zelma; Cj, Grossman; Ga, Roselle

doi:10.1016/0270-9139(91)90042-t

Cited by 74 publications

(58 citation statements)

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“…In such cases, which are often without earlier biopsy, the final histology might be indeterminate for cause. Second, at least 31% of the patients in this and other studies had coexistent conditions that alone could have been the indication for liver transplantation (7,(13)(14)(15)(16)(17)(18). Indeed, native livers from hepatitis C-infected patients here and in other studies often showed morphology of chronic hepatitis rather than alcohol injury ( Table 1), suggesting that alcohol had exacerbated viral damage rather than the other way around (19,20).…”

Section: Discussionmentioning

confidence: 75%

Liver Transplantation for Alcoholic Cirrhosis: Long Term Follow-Up and Impact of Disease Recurrence1

et al. 2001

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Section: Discussionmentioning

confidence: 75%

Liver Transplantation for Alcoholic Cirrhosis: Long Term Follow-Up and Impact of Disease Recurrence1

et al. 2001

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“…17,[41][42][43][44] Furthermore, the consumption of alcohol appears to accelerate liver disease in patients with viral hepatitis. [45][46][47][48] Therefore, it is important for transplant specialists to evaluate for alcohol dependence or abuse, not alcoholic liver disease per se.…”

Section: Discussionmentioning

confidence: 99%

Long-term follow-up of patients diagnosed with alcohol dependence or alcohol abuse who were evaluated for liver transplantation

Gish¹

2001

Liver Transplantation

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The selection of patients with cirrhosis and the diagnosis of alcohol dependence or abuse who have a long-term high probability of abstinence after orthotopic liver transplantation (OLT) may enhance patient survival and outcomes. The aim of this study is to identify factors that would predict which patients would consume alcohol after OLT. Sixty-one patients with a history of alcohol dependence or abuse underwent OLT from June 1989 to June 1994 and were followed up monthly for a median of 6.9 years after OLT (range, 2.5 to 9.3 years). Survival analysis techniques (Cox proportional hazard model) were used to identify patients at high risk for recidivism. Recidivism occurred in 12 of 61 patients (20%) after OLT during follow-up. Noncompliance, with a relative hazard of 20.9 (95% confidence interval [CI], 5.6 to 78.3; P < .001), and personality disorder, with a relative hazard of 6.0 (95% CI, 1.9 to 18.7; P ‫؍‬ .002), independently predicted recidivism among patients who underwent OLT. These data indicate that specific behaviors and psychiatric diagnoses can be used to select patients at high risk for drinking alcohol before and after OLT. (Liver Transpl 2001;7:581-587.)

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“…17 Similar conclusions have been reached by earlier studies that examined much smaller and select population samples. 16,[29][30][31][32] Conversely, a number of investigators have failed to find a relationship between excessive alcohol intake and the presence of cirrhosis 5,18 or the histological severity of liver disease. 33 Likewise, another report through the use of a hierarchical statistical model found that alcohol and HCV were additive, rather than multiplicative, in the development of cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Role of alcohol in the progression of liver disease caused by hepatitis C virus infection

et al. 1998

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In patients with chronic hepatitis C, alcohol consumption has been proposed as a risk factor for the progression of liver disease; however, evidence for this remains conflicting. Two hundred thirty-four anti-hepatitis C virus (HCV)-positive patients who had a liver biopsy performed within the past 24 months were studied. Demographic data and information on risk factors were recorded. A detailed lifetime alcohol consumption history was obtained. Viral studies included HCV viral titer and HCV genotype. Mean age (؎ SEM) of the group was 40.8 ؎ 0.7 years. One hundred sixty-six (71%) were male. A risk factor for HCV infection was found in 195 patients (86%). Genotype distribution was: 1b: 22%; 1a: 15%; 1(nonsubtypable): 15%; 3a: 34%; and 2: 7%. Fifty (21%) patients had cirrhosis. Patients with cirrhosis were older (51.6 ؎ 1.8 years) than those with chronic hepatitis (37.6 ؎ 0.6 years; P ‫؍‬ .0001), were infected at an older age (25.9 ؎ 2.0 vs. 20.9 ؎ 0.6 years; P ‫؍‬ .001), and had a longer duration of infection After exposure to hepatitis C virus (HCV), over 70% of persons will fail to clear the infection and become chronic carriers. These individuals develop chronic hepatitis of varying severity.

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Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevance

Cited by 74 publications

References 0 publications

Liver Transplantation for Alcoholic Cirrhosis: Long Term Follow-Up and Impact of Disease Recurrence1

Liver Transplantation for Alcoholic Cirrhosis: Long Term Follow-Up and Impact of Disease Recurrence1

Long-term follow-up of patients diagnosed with alcohol dependence or alcohol abuse who were evaluated for liver transplantation

Role of alcohol in the progression of liver disease caused by hepatitis C virus infection

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