Antibodies to gangliosides and galactocerebroside in patients with Guillain–Barré syndrome with preceding Campylobacter jejuni and other identical infections

Hao, Qian; Saida, Takahiko; Kuroki, Shigekazu; Nishimura, Masataka; Nukina, Masafumi; Obayashi, Hiroshi; Saida, Kyôko

doi:10.1016/s0165-5728(97)00166-5

Cited by 93 publications

(42 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kuroki et al (17) reported that 30% of 46 GBS patients in the Kinki district of Japan had positive stool cultures. In a subsequent study, these authors isolated 13 strains (17%) of C. jejuni from 76 patients (9). In contrast, 8% of 103 patients had positive cultures in England (25), and 9% of 138 patients had positive cultures in The Netherlands (28).…”

Section: Discussionmentioning

confidence: 99%

“…GBS/FS patients therefore frequently have negative stool cultures. Kuroki's group (9) reported that all 13 positive stool specimens were obtained within 10 days after onset of GBS symptoms, and 9 of the 13 specimens were obtained within 5 days. We could isolate C. jejuni from stool specimens obtained more than 1 month after the onset of GBS (the 35th day) or FS (the 40th day).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology ofCampylobacter jejuniIsolated from Patients with Guillain-Barré and Fisher Syndromes in Japan

et al. 2005

View full text Add to dashboard Cite

Campylobacter jejuni isolation is the standard for the diagnosis of this type of bacterial infection, but there have been no epidemiological studies of a large number of C. jejuni isolates from patients with Guillain-Barré syndrome (GBS) and Fisher syndrome (FS). For 13 years, stool specimens from GBS/FS patients have been sent from 378 hospitals throughout Japan to the Tokyo Metropolitan Institute of Public Health. A total of 113 strains (11%) were isolated from the stool specimens from 1,049 patients. The isolation rate did not differ by region. The rates were 22% for 449 patients with a history of diarrhea and 2% for the others. An additional 18 isolates were provided by various hospitals. There was no noticeable seasonal distribution in the onset of C. jejuni isolated from patients with GBS/FS. The male/female ratios were 1.7:1 for GBS and 2.2:1 for FS. The patient age range showed a peak in 10-to 30-year-old subjects who had GBS and in 10-to 20-year-old subjects who had FS. The predominance of young adults and male patients who had C. jejuni-associated GBS/FS may be related to the preponderance of young adults and male patients who had C. jejuni enteritis. The median interval from diarrhea onset to neurologic symptom onset was 10 days for GBS/FS. Penner's C. jejuni serotype HS:19 was more frequently present in GBS (67%) than in enteritis (6%) patients. HS:2 was more frequent in FS (41%) than in enteritis (14%) patients. These findings suggest that certain C. jejuni strains specifically trigger GBS and that others specifically trigger FS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Epidemiology ofCampylobacter jejuniIsolated from Patients with Guillain-Barré and Fisher Syndromes in Japan

et al. 2005

View full text Add to dashboard Cite

show abstract

“…• belonging to infectious agents that have been reported as related to or concomitant, even occasionally, with GBS, ie, C. jejuni, 18,19 Peptide matching analyses were conducted using the pentapeptide as a minimal immune unit [59][60][61] and utilizing the elsewhere described pentapeptide platform shared between ZIKV and human proteins that, when altered, may associate with GBS. 49 In brief, GBS-related proteins were obtained from UniProtKB 51 using the keywords "myelin, (de)myelination, axonal neuropathy".…”

Section: Methodsmentioning

confidence: 99%

“…[15][16][17] In parallel, a large body of research has investigated the possible association between GBS and infections. In particular, Campylobacter jejuni and Mycoplasma pneumoniae infections have been related to the disease, 18-22 most possibly through autoimmune cross-reactive mechanisms. [23][24][25][26] At a lesser extent, human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) might also be involved in GBS.…”

Section: Introductionmentioning

confidence: 99%

The Guillain–Barrè peptide signatures: from Zika virus to Campylobacter, and beyond

Lucchese¹,

Kanduc²

2017

VAAT

View full text Add to dashboard Cite

Scientific attention has focused recently on the link between Guillain-Barrè syndrome (GBS) and Zika virus (ZIKV). Two related questions emerged: 1) what triggered the violent 2014 outbreak of a virus, which, first identified in 1947, had caused only a limited number of documented cases of human infection until 2007 and 2) which molecular mechanism(s) relate ZIKV active infection to GBS, an autoimmune inflammatory polyradiculoneuropathy. Capitalizing on the increased interest on ZIKV and hypothesizing the involvement of autoimmune mechanisms, we searched for minimal epitopic determinants shared between ZIKV and other GBS-related pathogens -namely, Epstein-Barr virus, human cytomegalovirus, influenza virus, Campylobacter jejuni, and Mycoplasma pneumoniae, among others -and human proteins that, when altered, have been associated with myelin disorders and axonopathies. We report a considerable peptide matching that links GBS-related pathogens to human proteins related to myelin disorders and axonopathies. Crucially, the shared pentapeptides repeatedly occur throughout numerous epitopes validated as immunopositive by a conspicuous scientific literature. The data support a scenario where multiple different infections over time and resulting multiple cross-reactions may contribute to the pathogenesis of GBS. In practice, previous infection(s) might create immunologic memory able to trigger uncontrolled hyperimmunogenicity during a successive pathogen exposure. ZIKV pandemic appears to be an exemplar model for a proofof-concept of such multiple cross-reactivity mechanism.

show abstract

“…Moreover, the positive rate of CSF CMV‐IgG (48.3%) in patients with GBS is less than that in other nervous diseases (51.9%), indicating that CSF CMV‐IgG could not distinguish between GBS and other neurological diseases. Serum AGA can be found in 14% and 13.3% of the patients with GBS in the study conducted by Hao Q, Aliakbar T and their colleagues respectively (Hao et al., 1998; Taheraghdam et al., 2014). But 31% (9/29) of AGA was found in patients involved in our study, which is higher than the results of them, but lower than the values reported by other investigators (van den Berg et al., 2014; van Doorn & Jacobs, 2016).…”

Section: Discussionmentioning

confidence: 99%

Association of anti‐gangliosides antibodies and anti‐CMV antibodies in Guillain–Barré syndrome

et al. 2017

View full text Add to dashboard Cite

IntroductionNumerous types of infection were closely related to GBS, mainly including Campylobacter jejuni, Cytomegalovirus, which may lead to the production of anti‐gangliosides antibodies (AGA). Currently, although there are increased studies on the AGA and a few studies of anti‐CMV antibodies in GBS, the association between them remains poorly documented. Therefore, our research aims to analyze the correlation of anti‐CMV antibodies and AGA in GBS.MethodsA total of 29 patients with GBS were enrolled in this study. The CMV antibodies were tested by the electrochemiluminescence immunoassay “ECLIA” (Roche Diagnostics GmbH). The serum gangliosides were determined by The EUROLINE test kit.ResultsOf the 29 patients with GBS, 9 (31%) were AGA‐seropositive, in which 22 were CMV‐IgG positive in CSF at the same time, but all 29 samples were CMV‐IgM negative in both serum and CSF. In the AGA‐positive group, the rate of both serum and CSF positive was 87.5% (7/8), higher than 50% (7/14) of the negative group, although no statistical significance was found. In addition, we found that there was a trend of higher ratio of men, a younger age onset, less frequent preceding infection, a higher level of CSF proteins, and less frequent cranial nerve deficits, although the data did not reach a statistical significance.ConclusionIn spite of no statistical significance association was found between serum AGA and CMV‐IgG in serum and CSF. However, we found that there was a trend of high positive rate of both serum and CSF‐CMV‐IgG in AGA‐positive than the negative group. So we should further expand the sample size to analyze the association between AGA and CMV or other neurotropic virus antibodies in various diseases, to observe whether they could be serological marker of these diseases (especially GBS) or the underlying pathogenesis.

show abstract

Antibodies to gangliosides and galactocerebroside in patients with Guillain–Barré syndrome with preceding Campylobacter jejuni and other identical infections

Cited by 93 publications

References 39 publications

Epidemiology ofCampylobacter jejuniIsolated from Patients with Guillain-Barré and Fisher Syndromes in Japan

Epidemiology ofCampylobacter jejuniIsolated from Patients with Guillain-Barré and Fisher Syndromes in Japan

The Guillain–Barrè peptide signatures: from Zika virus to Campylobacter, and beyond

Association of anti‐gangliosides antibodies and anti‐CMV antibodies in Guillain–Barré syndrome

Contact Info

Product

Resources

About

Antibodies to gangliosides and galactocerebroside in patients with Guillain–Barré syndrome with preceding Campylobacter jejuni and other identical infections

Cited by 93 publications

References 39 publications

Epidemiology ofCampylobacter jejuniIsolated from Patients with Guillain-Barré and Fisher Syndromes in Japan

Epidemiology ofCampylobacter jejuniIsolated from Patients with Guillain-Barré and Fisher Syndromes in Japan

The Guillain&ndash;Barr&egrave; peptide signatures: from Zika virus to Campylobacter, and beyond

Association of anti‐gangliosides antibodies and anti‐CMV antibodies in Guillain–Barré syndrome

Contact Info

Product

Resources

About

The Guillain–Barrè peptide signatures: from Zika virus to Campylobacter, and beyond