Antibodies to endothelial cells in Kawasaki disease lyse endothelial cells without cytokine pretreatment

Fujieda, Mikiya; Oishi, Naobumi; Kurashige, Takanobu

doi:10.1046/j.1365-2249.1997.d01-894.x

Cited by 53 publications

(49 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 Antiendothelial cell antibodies have a role in a complement system or antibody-related endothelial cell cytotoxicity. [11][12][13] They are detected in serum samples from patients with certain diseases (such as Wegener granulomatosis, Takayasu arteritis, and Kawasaki syndrome) in which varying degrees of vascular wall injury are associated. Vasculitis is rare in patients without AECAs who have positive antineutrophil cytoplasmic antibodies, while the presence of AECAs is associated with an increased incidence of vasculitis.…”

Section: Discussionmentioning

confidence: 99%

The Role of Antiendothelial Cell Antibodies in the Development and Follow-up of Coronary and Peripheral Arterial Diseases

et al. 2008

View full text Add to dashboard Cite

Occlusive lesions in the arterial endothelium are often caused by formation of intimal hyperplasia and fibrinoid necrosis. The objective of this study was to investigate the association between antiendothelial cell antibodies (AECAs) and the development of coronary artery disease (CAD) and peripheral artery disease (PAD). In this study, 94 patients with CAD or PAD and 94 healthy volunteers serving as control subjects were examined. Frozen sections of human umbilical vein endothelial cells and primate smooth muscle cells were used to detect the presence of AECAs, which were found in 52 of 94 patients (55%) and in 15 of 94 controls (16%) ( P < .001). Endothelial structure tissue damage is a major factor in arterial diseases. In the present study, a statistically significant relationship was found between AECAs and the development of CAD and PAD. The presence of AECAs has been identified as a risk factor for these diseases. According to this study, AECAs are reliable prognosticators for the development of CAD and PAD. Further studies with large numbers of serum samples are under way.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of Antiendothelial Cell Antibodies in the Development and Follow-up of Coronary and Peripheral Arterial Diseases

et al. 2008

View full text Add to dashboard Cite

show abstract

“…In vasculitides, it was suggested that endothelium was not only the target of injury, but also an active participant of vasculitic damage [9]. Anti-endothelial cell antibodies (AECA) have been described in various autoimmune and vasculitic disorders [10][11][12][13][14][15][16][17][18]. They have been implicated in the pathogenesis of vascular injury common to these disorders.…”

Section: Introductionmentioning

confidence: 99%

Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity

Zhao

Zhang

et al. 2005

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryIncreasing evidence has demonstrated that propylthiouracil (PTU) could induce ANCA positive vasculitis. However, our previous work has suggested that only one-fifth of the PTU-induced ANCA positive patients had clinical vasculitis and so the mechanism is not clear. Anti-endothelial cell antibodies (AECA) have been implicated in the pathogenesis of various vasculitides, including primary ANCA positive systemic vasculitis. The purpose of this study is to investigate the prevalence of AECA and their possible role in the pathogenesis of patients with PTU-induced ANCA positive vasculitis. Sera from 11 patients with PTU-induced ANCA positive vasculitis at both active and quiescent phases, and sera from 10 patients with PTU-induced ANCA but without clinical vasculitis, were studied. Sera from 30 healthy blood donors were collected as normal controls. Soluble proteins from 1% Triton-100 extracted in vitro cultured human umbilical vein endothelial cells were used as antigens and an immunoblotting technique was performed to determine the presence of AECA, and their specific target antigens were identified. In patients with PTU-induced ANCA positive vasculitis, 10 of the 11 patients in an active phase of disease were serum IgG-AECA positive and six protein bands of endothelial antigens could be blotted (61 kD, 69 kD, 77 kD, 85 kD, 91 kD and 97 kD). However, in the quiescent phase, seven of the 10 positive sera turned negative. None of the ANCA positive but vasculitis negative patients or normal controls were AECA positive. In conclusion, AECA could be found in sera from patients with PTU-induced ANCA positive vasculitis and were associated more closely with vasculitic disease activity.

show abstract

“…Other researchers have demonstrated the presence of cytotoxic anti-endothelial cell antibodies in the serum of patients with Kawasaki's disease (30,31,32), hemolytic-uremic syndrome (33), and individuals with carotid atherosclerosis (34). Since mAb 3.B6 reacted with human valve endothelium, we determined if mAb 3.B6 was cytotoxic for endothelial cells.…”

mentioning

confidence: 97%

Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin

Galvin¹,

Hemric²,

Ward³

et al. 2000

J. Clin. Invest.

204

182

View full text Add to dashboard Cite

Antibodies to endothelial cells in Kawasaki disease lyse endothelial cells without cytokine pretreatment

Cited by 53 publications

References 12 publications

The Role of Antiendothelial Cell Antibodies in the Development and Follow-up of Coronary and Peripheral Arterial Diseases

The Role of Antiendothelial Cell Antibodies in the Development and Follow-up of Coronary and Peripheral Arterial Diseases

Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity

Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin

Contact Info

Product

Resources

About