Antibodies to Chlamydia trachomatis in acute salpingitis.

Treharne, J D; Ripa, K T; Mårdh, Per‐Anders; Svensson, Lovisa; Weström, L; Darougar, S

doi:10.1136/sti.55.1.26

Cited by 63 publications

(43 citation statements)

References 11 publications

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“…The anti-chlamydial IgM seropositivity of 60% among the primary infertility group, highlighted a significant correlation between the prevalence of the antichlamydial antibodies and the tubal factor infertility which was secondary to acute salpingitis. These findings were consistent with other reports which were made by Treharne (73%) [13], Bhujwala (60%) [14] and Ghinsberg (43%) [15].…”

Section: Discussionsupporting

confidence: 83%

Association of the Serum Anti-chlamydial Antibodies with Tubal Infertility

Surana

Rastogi²,

Nirwan³

2012

JCDR

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Background: Infertility is increasingly becoming a significant health problem in many areas of the world. The infection which is caused by Chlamydia trachomatis is a major cause of tubal factor infertility secondary to salpingitis. However, the data which pertains to infertility attributed to the C. trachomatis infection is limited in India. Aims:To evaluate the chlamydial infection in women who suffered from infertility and to investigate the possible role of the chlamydia serology as a screening test for tubal infertility.Method: This study was aimed at evaluating the chlamydial infection in fifty women with primary infertility and at investigating the possible role of the chlamydial serology as a screening test for tubal infertility, by the detection of the anti-chlamydial IgM antibodies by using E.L.I.S.A. Setting and Design:The present prospective study was carried out at a tertiary care hospital in north India. Results:In this study, a high seropositivity (60%) for the antichlamydial antibody was observed. 52% females showed bilateral tubal blockage, while the most common site of the blockage was the ampullary portion (36%). Conclusion:These findings highlighted a strong correlation between the tubal factor infertility and the antichlamydial antibodies. It also stressed on the need of the screening of infertile women for C. trachomatis with laboratory investigations, which could provide a rapid and specific diagnosis so that early therapeutic interventions could be instituted.Ashish surAnA, VijAylAtA rAstogi, Prem singh nirWAn

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Section: Discussionsupporting

confidence: 83%

Association of the Serum Anti-chlamydial Antibodies with Tubal Infertility

Surana

Rastogi²,

Nirwan³

2012

JCDR

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“…Note that among the cases, a high proportion of the titers that would normally be considered positive (1:32 and above) are at particularly high levels. This has been observed repeatedly in similar studies of TFI (11,15,16,30,31), and PID (10,18). In other words, women at higher risk of reproductive damage are more likely to be CT antibody positive, and are more likely to have particularly high titers than antibody-positive controls.…”

supporting

confidence: 53%

“…The major studies of reproductive outcomes in women with PID (5-7) have been restricted to the small proportion of PID (8) that is diagnosed in hospital. In the 1980s and 1990s large numbers of serological case-control studies were carried out, comparing serum antibody levels in women with PID, EP or infertility, with controls (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). These studies invariably showed strong associations between detection of CT antibodies and reproductive damage, but it was difficult to draw quantitative conclusions from them, partly because of confounding between CT and other pathogens also implicated in reproductive morbidity (20), and partly because of the poor, and imprecisely known, sensitivity and specificity of the assays used (21,22).…”

mentioning

confidence: 99%

Proportion of Tubal Factor Infertility due toChlamydia: Finite Mixture Modeling of Serum Antibody Titers

Ades¹,

Price²,

Kounali³

et al. 2017

Am. J. Epidemiol.

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms estimates based on the standard PEF formula from case-control studies were 0% and over 65%.Finite mixture modeling can be applied to serological data to obtain estimates of the proportion of reproductive damage attributable to Chlamydia trachomatis. Further studies should be undertaken using modern assays in contemporary, representative populations. <198 words>

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“…Information has accumulated about the association of chlamydial infection and pelvic inflammatory disease (PID).1-3 Treharne et 4 (containing >100 inclusion bodies) on culture, only one (5%) was in the same category on direct examination. 14 (70%) were in category 3, four (20%) in category 2, and one (15%) in category 1 on direct examination.…”

Section: Introductionmentioning

confidence: 99%