Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection

Miller, George; Rigsby, Michael O.; Heston, Lee; Grogan, Elizabeth; Sun, Ren; Metroka, Craig E.; Levy, Jay A.; Gao, Shou‐Jiang; Chang, Yuan; Moore, Patrick S.

doi:10.1056/nejm199605163342003

Cited by 244 publications

(164 citation statements)

References 33 publications

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“…We used sera from patients with KS for a positive control, and all of these sera were positive for HHV-8 IgG antibody. The prevalence of HHV-8 in 5.2% of blood donors in the USA correlates with that previously reported using both latent IFA and immunoblot assays (Gao et al, 1996a;Kedes et al, 1996;Miller et al, 1996). The higher prevalence of HHV-8 in adults from Uganda (38.7%) and Zambia (37.5%) correlates with the incidence of endemic KS and the high incidence of AIDS-associated KS in these countries (Wabinga et al, 1993).…”

Section: Age and Sex Of Donorssupporting

confidence: 84%

Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa

Ablashi¹,

Chatlynne²,

Cooper³

et al. 1999

Br J Cancer

148

106

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Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries in both the healthy and the HIV-infected populations. This correlates with the fact that hardly any AIDS-related Kaposi’s sarcoma has been reported in these countries. In contrast, the African countries of Ghana, Uganda and Zambia showed high seroprevalences in both healthy and HIV-infected populations. This suggests that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity. Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres show that only 3/82 (3.7%) have antibody to HHV-8, demonstrating that there is little, if any, cross-reactivity between antibodies to these two gamma viruses. © 1999 Cancer Research Campaign

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Section: Age and Sex Of Donorssupporting

confidence: 84%

Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa

Ablashi¹,

Chatlynne²,

Cooper³

et al. 1999

Br J Cancer

148

106

View full text Add to dashboard Cite

show abstract

“…Because the full complement of viral DNA is retained in the nucleus, under the appropriate circumstances the second program of viral gene expression, lytic replication, can be activated. In this program, expression of virtually all viral genes is activated, in a temporally regulated cascade; infectious viral progeny are produced, and the infected cell is killed (6,80). The physiologic signals that trigger lytic KSHV reactivation in vivo are unknown.…”

Section: Kshv Virology: a Primermentioning

confidence: 99%

KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine

Ganem¹

2010

J. Clin. Invest.

336

380

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“…Latently infected cells display a low level of spontaneous lytic replication, characterized by a temporally regulated cascade of viral gene expression, replication of the viral DNA, and the release of virus particles. Lytic replication can be induced in latently infected cells by the addition of phorbol esters or butyrate or by overexpression of the viral switch protein, RTA (3,7,8,22,25,31,45,47,48,63,67). The physiological triggers controlling RTA expression (and thus, the shift between lytic and latent infection) are unknown, however (44).…”

mentioning

confidence: 99%

Host and Viral Proteins in the Virion of Kaposi's Sarcoma-Associated Herpesvirus

Bechtel

Winant

Ganem

2005

J Virol

164

185

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Infection of cultured cells with Kaposi's sarcoma associated herpesvirus (KSHV) typically establishes a latent infection, in which only a few viral genes are expressed. Recently, it has been reported that a subset of lytic genes are transiently expressed very early after viral entry but that this burst of abortive lytic gene expression is terminated with the supervention of latency (H. H. Krishnan, P. P. Naranatt, M. S. Smith, L. Zeng, C. Bloomer, and B. Chandran, J. Virol. 78:3601-3620, 2004). To identify molecules imported into cells by KSHV that might influence this gene expression program, we have examined the protein composition of the KSHV particle. Immunoblotting of virus particles demonstrated that RTA, the lytic switch protein, and RAP, a viral protein that is a transcriptional and cell cycle modulator, were both incorporated into virus particles. In a second approach, polypeptides isolated from purified virions were identified by mass-spectrometric analysis of their constituent tryptic peptides. With this approach we were able to identify 18 major virion proteins, including structural, regulatory, and signaling proteins of both viral and cellular origin.

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Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection

Abstract: The presence of antibodies to a KSHV antigenic peptide correlates with the presence of Kaposi's sarcoma in a high-risk population and provides further evidence of an etiologic role for KSHV.

Cited by 244 publications

References 33 publications

Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa

Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa

KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine

Host and Viral Proteins in the Virion of Kaposi's Sarcoma-Associated Herpesvirus

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