Antibodies to acetylcholine receptors in patients with different clinical forms of myasthenia and Lambert-Eaton myasthenic syndrome

Сиднев, Д.В.; Karganov, M. Yu.; Щербакова, Н.И.; Алчинова, И. Б.; Санадзе, А.Г.

doi:10.1007/s11055-007-0160-y

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…However, the anti-AChR antibody titers in seropositive LEMS patients were reportedly low (0.88-3.03 nM),7 and the only significant increases were in those with lung carcinomas. There have been several cases of establishing the immunological basis of combined MG and LEMS with positive anti-AChR and anti-VGCC antibody tests; none of these cases also had either thymoma or small-cell lung cancer 2.…”

Section: Discussionmentioning

confidence: 90%

“…An elevated anti-AChR antibody titer is generally specific to MG patients, but a previous report argued that seropositivity of this antibody may represent a nonpathogenic epiphenomenon or a false-positive response 6,7. However, the anti-AChR antibody titers in seropositive LEMS patients were reportedly low (0.88-3.03 nM),7 and the only significant increases were in those with lung carcinomas.…”

Section: Discussionmentioning

confidence: 95%

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A Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome

et al. 2012

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BackgroundThe coexistence of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) is very rare and remains controversial.Case ReportA 48-year-old woman initially presented with noticeable right ptosis and intermittent diplopia. She then developed fluctuating proximal limb weakness and difficulty in swallowing. The serum titer of anti-acetylcholine-receptor antibody was elevated and the edrophonium (Tensilon) test was positive. However, repetitive nerve stimulation revealed abnormalities typical of LEMS. The patient exhibited a good response to treatment with anticholinesterase inhibitors and steroids, and long-term evaluation disclosed that she presented with the clinical, electrophysiological, and immunological characteristics of both diseases.ConclusionsThe reported clinical and electrophysiological features suggest that this patient was a very rare case of combined MG and LEMS.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 95%

A Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome

et al. 2012

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“…The search for the relationship between the disease severity and the distribution pattern of subfraction serum components was of particular interest, because there is no correlation between the concentration of anti-AChR antibodies and activity of the pathological process in MG. The latter fact was confirmed in our study (Figure 3): the content of anti-AChR antibodies was similar in patients with grade 1, grade 2, and grade 3 MG. At the same time, our previous results brought hope for detection of specific features of spectra using the LCS method [10].…”

Section: Resultsmentioning

confidence: 73%

“…Thus, elevated concentration of antibodies to AChR is a reliable diagnostic marker, but due to the absence of correlations with other clinically important parameters, the use of this parameter is confined to the diagnostic tests [10].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

et al. 2014

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The objective of this study was to compare informative value of traditional approach (anti-AChR antibody radioimmunoassay) and evaluation of metabolic shifts by laser correlation spectroscopy in myasthenia gravis. The method based on changes in spectral characteristics of laser radiation caused by scattering in a disperse system yields a histogram reflecting particle contribution into light scatter as a function of particle radius in nanometers. The spectrum of anti-AChR-positive serum is characterized by appreciably increased contribution of particles with a radius 4.6–6.2 nm. Binding of serum components with solubilized AChR confirms that this peak is determined by elevated concentration of antibodies to this receptor. The search for the relationship between the disease severity and the distribution pattern of subfraction serum components revealed three informative zones: 6–15, 27–67, and 127–223 nm. In patients without disturbances of vital functions, the contribution of the first zone particles into light scatter increases and that of the third zone particles decreases. Considerable differences attaining the level of statistical significance in zones 4–6 and 20 nm were revealed in the spectra of serum from patients with myasthenia gravis of the same severity with and without thymoma. This opens prospects for dynamic monitoring of the efficiency of therapy.

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“…Таким образом, повышение концентрации антител к АХР -относительно надежный диагностический критерий. Однако в связи с отсутствием корреляции с какимилибо клинически важными параметрами ценность данного показателя ограничивается [10].…”

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A comparative analysis of the informative value of anti-AChR-antibody radioimmunoassay and laser correlation spectroscopy in myasthenia gravis

Алчинова

Yakovenko

Сиднев

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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In patients without disturbances of vital functions, the contribution of the first zone particles into light scatter increases and that of the third zone particles decreases. Considerable differences attaining the level of statistical significance in zones 6 and 20 nm were revealed in the spectra of serum from patients with myasthenia gravis of the same severity with and without thymoma. This opens prospects for dynamic monitoring of the efficiency of therapy.

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Antibodies to acetylcholine receptors in patients with different clinical forms of myasthenia and Lambert-Eaton myasthenic syndrome

Cited by 6 publications

References 19 publications

A Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome

A Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome

Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

A comparative analysis of the informative value of anti-AChR-antibody radioimmunoassay and laser correlation spectroscopy in myasthenia gravis

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