Antibodies Possessing a Catalytic Activity (Natural Abzymes) at Norm and Pathology

Abstract

The review is focused on the analysis of published data and the results obtained by the authors about the catalytic activity of antibodies (abzymes) at norm and pathology. Potential pathogenic and beneficial role of natural abzymes is discussed.Abzymes, possessing protease activity were named as "protabzymes". As was mentioned above, protabzymes, capable of hydrolyzing intestinal

Anti-DNA (“Cationic”) and Ani-Histone (“Anionic”) Auto- Antibodies: Two Sides of One Coin?

“…Obviously, that an important characteristic feature of these auto-Abs is their cross-reactivity to different cellular antigens, as well as, their catalytic activity towards nucleic acids and proteins. The obtained data outlined the correlation between cytotoxicity and DNAhydrolyzing properties of a "cationic" auto-Abs [6][7][8], as well as mitogenic activity of an "anionic" auto-Abs and their proteolytic properties also have been demonstrated [9,[14][15][16]. Interestingly, that the level of proteolytically active IgGs in blood serum of SLE patients towards both histone H1 and myelin basic protein tightly correlates with the disease severity in these patients [17].…”