Antibodies internalization mechanisms by dendritic cells and their role in therapeutic antibody immunogenicity
Maria Lteif,
Marc Pallardy,
Isabelle Turbica
Abstract:Internalization and processing by antigen‐presenting cells such as dendritic cells (DCs) are critical steps for initiating a T‐cell response to therapeutic antibodies. Consequences are the production of neutralizing antidrug antibodies altering the clinical response, the presence of immune complexes, and, in some rare cases, hypersensitivity reactions. In recent years, significant progress has been made in the knowledge of cellular uptake mechanisms of antibodies in DCs. The uptake of antibodies could be direc… Show more
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