1967
DOI: 10.1016/s0140-6736(67)92539-1
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Antibodies in the Families of Thyrotoxic Patients

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1969
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Cited by 46 publications
(8 citation statements)
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“…type 2 diabetes, 3·5), hence linkage analysis has been more successful in single gene disorders. In Graves' disease, we have estimated a s of around 10 on the basis of epidemiological data provided in studies by Bartels (1941) and Howell-Evans et al (1967). However, follow-up data from the Whickam survey have shown that Graves' disease is more common than previously believed, with a prevalence of approximately 2% (Vanderpump et al 1995).…”
Section: Classical Linkage Analysismentioning
confidence: 99%
“…type 2 diabetes, 3·5), hence linkage analysis has been more successful in single gene disorders. In Graves' disease, we have estimated a s of around 10 on the basis of epidemiological data provided in studies by Bartels (1941) and Howell-Evans et al (1967). However, follow-up data from the Whickam survey have shown that Graves' disease is more common than previously believed, with a prevalence of approximately 2% (Vanderpump et al 1995).…”
Section: Classical Linkage Analysismentioning
confidence: 99%
“…However, these results have to be interpreted with caution because there is always a risk of bias when hospitalized subjects are used as probands in family studies (20), ie, the probability for a family to become ascertained is a function of the number of affected subjects in that family. Bartels (9) and Martin and Fisher (10) found that the probands' sisters were affected more often than the parents (mothers), whereas in the study of Howel-Evans et al (11), the mothers were more frequently affected. Stenszky et al (12), however, found an almost equal distribution of GD among the probands' female relatives.…”
Section: Family and Twin Studiesmentioning
confidence: 97%
“…In Caucasians, a role for heredity in GD is suggested by the aggregation of hyperthyroidism within families (9)(10)(11)(12)(13) and by higher concordance rates for MZ twins than DZ twins (6)(7)(8). Family and twin studies are the classic meth- 1 Department of Endocrinology M, Odense University Hospital, Odense C, Denmark.…”
Section: Family and Twin Studiesmentioning
confidence: 99%
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