Antibodies against neutrophil extracellular traps (NETs) potentiate clinical performance of anti-double-stranded DNA antibodies in systemic lupus erythematosus

Zhan, Minghua; Wang, Ziwei; Bao, Huizhang; Di, Chun; Xia, Changsheng; Zhang, Xuan; Liu, Yudong

doi:10.1016/j.clim.2023.109297

Cited by 5 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antigen specificities of these antibodies were analyzed using a 120-antigen microarray panel, and it was suggested that IgG antibodies to NETs were likely to be driven via their reactivity with protein antigens in the NETs, while the IgM antibodies to NETs were likely to target DNA. In another study, anti-NET antibodies were detected in 35.7% of patients with SLE [60]. Interestingly, 37.0% of these patients were negative for anti-dsDNA antibodies, indicating that DNA is not necessarily a major antigen in NETs, even in SLE.…”

Section: Anti-net Antibodiesmentioning

confidence: 93%

An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus

Kubota

2023

IJMS

View full text Add to dashboard Cite

Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but their pathogenetic role is not fully understood. Accumulating evidence suggests that some anti-DNA antibodies enter different types of live cells and affect the pathophysiology of SLE by stimulating or impairing these cells. Circulating neutrophils in SLE are activated by a type I interferon or other stimuli and are primed to release neutrophil extracellular traps (NETs) on additional stimulation. Anti-DNA antibodies are also involved in this process and may induce NET release. Thereafter, they bind and protect extracellular DNA in the NETs from digestion by nucleases, resulting in increased NET immunogenicity. This review discusses the pathogenetic role of anti-DNA antibodies in SLE, mainly focusing on recent progress in the two research fields concerning antibody penetration into live cells and NETosis.

show abstract

Section: Anti-net Antibodiesmentioning

confidence: 93%

An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus

Kubota

2023

IJMS

View full text Add to dashboard Cite

show abstract

Recent advances on neutrophil dysregulation in the pathogenesis of rheumatic diseases

Chen,

Wang,

Liu

et al. 2023

Current Opinion in Rheumatology

Self Cite

View full text Add to dashboard Cite

Purpose of review The exact pathogenic mechanisms of rheumatic diseases (RMD) remain largely unknown. Increasing evidence highlights a pathogenic role of neutrophil dysregulation in the development of RMD. Recent findings The purpose of this review is to present a current overview of recent advancements in understanding the role of neutrophil dysfunction in the development of RMD. Additionally, this review will discuss strategies for targeting pathways associated with neutrophil dysregulation as potential treatments for RMD. One specific aspect of neutrophil dysregulation, known as neutrophil extracellular traps (NETs), will be explored. NETs have been found to contribute to chronic pulmonary inflammation and fibrosis, as well as serve as DNA scaffolds for binding autoantigens, including both citrullinated and carbamylated autoantigens. Putative therapies, such as 6-gingerol or defibrotide, have demonstrated beneficial effects in the treatment of RMD by suppressing NETs formation. Summary Recent advances have significantly reinforced the crucial role of neutrophil dysregulation in the pathogenesis of RMD. A deeper understanding of the potential mechanisms underlying this pathogenic process would aid in the development of more precise and effective targeting strategies, thus ultimately improving the outcomes of RMD.

show abstract

A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases

Li,

Wu,

Huang

et al. 2023

Immunological Reviews

View full text Add to dashboard Cite

SummaryNeutrophils are important in the context of innate immunity and actively contribute to the progression of diverse autoimmune disorders. Distinct death mechanisms of neutrophils may exhibit specific and pivotal roles in autoimmune diseases and disease pathogenesis through the orchestration of immune homeostasis, the facilitation of autoantibody production, the induction of tissue and organ damage, and the incitement of pathological alterations. In recent years, more studies have provided in‐depth examination of various neutrophil death modes, revealing nuances that challenge conventional understanding and underscoring their potential clinical utility in diagnosis and treatment. This review explores the multifaceted processes and characteristics of neutrophil death, with a focus on tailored investigations within various autoimmune diseases. It also highlights the potential interplay between neutrophil death and the landscape of autoimmune disorders. The review encapsulates the pertinent pathways implicated in various neutrophil death mechanisms across diverse autoimmune diseases while also charts possible avenues for future research.

show abstract

Antibodies against neutrophil extracellular traps (NETs) potentiate clinical performance of anti-double-stranded DNA antibodies in systemic lupus erythematosus

Cited by 5 publications

References 26 publications

An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus

An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus

Recent advances on neutrophil dysregulation in the pathogenesis of rheumatic diseases

A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases

Contact Info

Product

Resources

About