Antibodies Against Malaria Sporozoites in Patients with Acute Uncomplicated Malaria and Patients with Cerebral Malaria

Tapchaisri, Pramuan; Asavanich, Achara; Limsuwan, S; Tharavanij, S; Harinasuta, Khunying Tranakchit

doi:10.4269/ajtmh.1985.34.831

Cited by 15 publications

(12 citation statements)

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“…The basis for this difference is not known. Malaria may variably suppress both humoral and cellular responses to third party antigens 18,19 and immune response to P. falciparum itself may be reduced in patients with complicated cerebral disease, 15,[20][21][22] or repeated malaria attacks. 23 Differences in the immune response between patient groups may have several explanations, including differences in parasite virulence, 24,25 genetics of the human host, and differences in immunity related to variations in malaria exposure.…”

Section: Discussionmentioning

confidence: 99%

Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria.

Perlmann¹,

Perlmann²,

Looareesuwan³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. Plasmodial infection results in a significant elevation of the blood concentrations of immunoglobulins including IgE. Two well-characterized groups of adult Thai patients with either uncomplicated or severe Plasmodium falciparum malaria were studied over a period of four weeks. The mean parasitemias were approximately three-fold higher in patients with severe malaria than in those with uncomplicated disease. The mean concentrations of both total IgG and IgG antiplasmodial antibodies tended to be highest in the group with uncomplicated disease while total IgE and IgE antibodies were higher in the group with severe disease. The IgE antibodies detected in approximately 65% of the patients were positively correlated to parasitemia. These results suggest that antiplasmodial IgG antibodies are involved in reducing the severity of P. falciparum malaria, while IgE antibodies may contribute to the pathogenesis of this infection.

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Section: Discussionmentioning

confidence: 99%

Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria.

Perlmann¹,

Perlmann²,

Looareesuwan³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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“…They help in the definining and collaboration of baseline data on the development of natural immunity to malaria in remote locations. Thus helping in monitoring progress made in malaria control programmers (Tapchaisri et al, 1985). The seasonality of malaria has been recorded by the likes of Webster et al (1988) and Babiker et.…”

Section: Introductionmentioning

confidence: 95%

Seasonal variations in antibody response to a Plasmodium falciparum recombinant circumsporozoite antigen in two villages in south western Nigeria

Ozurumba¹,

Anumudu²,

Nwagwu³

2009

African Journal of Biomedical Research

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“…[17][18][19] Lower anti-sporozoite IgG antibodies in Thai individuals with cerebral compared with uncomplicated malaria have also been reported. 20 In contrast, a comparative study of Gambian children with either severe or mild malaria failed to demonstrate a difference in either total anti-P. falciparum or anti-sporozoite antibody responses. 21 As part of a case-control study of severe malaria in 200 young Gabonese children we measured anti-P. falciparum antibody responses before and at different times after treatment in order to evaluate possible differences which might be related to the severity of the malaria attack.…”

Section: Introductionmentioning

confidence: 96%

Antibody responses to Plasmodium falciparum: evolution according to the severity of a prior clinical episode and association with subsequent reinfection.

Luty¹,

Ulbert²,

Lell³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. We measured sporozoite-and total parasite antigen-specific IgG and IgM antibodies before and after treatment in matched groups of Gabonese children who presented with either mild or severe Plasmodium falciparum malaria. We investigated the influence of various parameters on these antibody responses, including clinical presentation, age, and post-treatment reinfection profiles. IgG but not IgM responses were strongly influenced by both clinical and parasitological status. IgG responses to the repeat region of the circumsporozoite protein, which were low at admission, particularly so in those with severe anemia, increased after treatment but showed no association with either age or reinfection profiles. Total parasite antigen-specific IgG responses were strongly influenced by parasitological status, and also differed significantly when segregated according to clinical status at admission, age, and reinfection histories. Most notably, anti-parasite IgG responses measured when children were parasite-free were higher and a good indicator of recent reinfections in those who presented with mild rather than with severe malaria. The profile of responses in the latter group suggests some immune system dysfunction, which may reflect the induction of tolerance to parasite antigens.

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Antibodies Against Malaria Sporozoites in Patients with Acute Uncomplicated Malaria and Patients with Cerebral Malaria

Cited by 15 publications

References 0 publications

Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria.

Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria.

Seasonal variations in antibody response to a Plasmodium falciparum recombinant circumsporozoite antigen in two villages in south western Nigeria

Antibody responses to Plasmodium falciparum: evolution according to the severity of a prior clinical episode and association with subsequent reinfection.

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