Antibodies against Human Herpesvirus 8 in Black South African Patients with Cancer

Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and human immunodeficiency virus (HIV) in relation to the risk and clinical presentation of Kaposi's sarcoma in Uganda

“…However, results presented here in relation to KSHV antibody titres are in accord with those reported by Sitas et al (1999) from a case -control study of black South African cancer patients. Furthermore, in a cohort study of HIV-infected men in Europe, Rezza et al (1999) showed that high titres of anti-KSHV antibodies were predictive of the subsequent development of Kaposi's sarcoma among KSHV-infected individuals.…”

“…The fluorescent signal intensity was related to anti-KSHV antibody titre -the median titres were 1 : 800 for low-signal intensity ( þ ), 1 : 25 600 for medium-signal intensity ( þ þ ) and 1 : 51200 for high-signal intensity ( þ þ þ ). Further details of the testing procedure and scoring mechanism for signal intensity are described elsewhere (Sitas et al, 1999).…”

Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma

“…Of these, three studies identified evidence of KSHV-DNA in peripheral blood cells (Chang et al, 1996;Kasolo et al, 1997;Belec et al, 1998), two used a lytic antibody assay alone (He et al, 1998;Lampinen et al, 2000), five used a latent antibody assay alone Ariyoshi et al, 1998;Bestetti et al, 1998;Bourboulia et al, 1998;Sitas et al, 1999) and 18 used both a lytic and a latent assay (Lennette et al, 1996;Simpson et al, 1996;Mayama et al, 1998;Olsen et al, 1988;Ablashi et al, 1999;Andreoni et al, 1999Andreoni et al, , 2002Enbom et al, 1999;Gessain et al, 1999;Wilkinson et al, 1999;Engels et al, 2000;Rezza et al, 2000;Gaye Serraino-Diallo et al, 2001;Kakoola et al, 2001;Nuvor et al, 2001;Serraino et al, 2001;Wawer et al, 2001). The results are presented in Table 1, together with the estimated cumulative incidence of Kaposi's sarcoma in men aged 0 -64 years in the period before HIV infection (Cook-Mozaffari et al, 1998).…”

The Evaluation of the Renal Transplant Candidates: Clinical Practice Guidelines

“…It has recently become evident that human herpes virus-8 (HHV-8) may be the cause of many, if not most, cases of Kaposi's sarcoma (86)(87)(88)(89)(90)(91). In a recent study, 17/25 (68%) of renal transplant recipients who had HHV-8 antibodies developed Kaposi's sarcoma, compared to only 1/33 (3%) seronegative patients (92).…”

“…Altogether, these studies suggest that screening for HHV-8 may be indicated in populations at increased risk for Kaposi's sarcoma. Risk factors include African or Middle East origin, past infection with hepatitis B, a family history of Kaposi's sarcoma, homosexual orientation and a prior history of Kaposi's sarcoma (87,88,(90)(91)(92). Patients who are HHV-8 antibody positive may wish to forego transplantation.…”