Antibodies against hepatitis C virus in mixed cryoglobulinemia patients

Ferri, Clodoveo; Greco, Francesco; Longombardo, G.; Palla, P; Moretti, A; Marzo, E; Fosella, Pv; Pasero, G; Bombardieri, Stefano

doi:10.1007/bf01726453

Cited by 133 publications

(103 citation statements)

References 26 publications

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“…The relative risk (RR) of being infected by each HCV genotype, as compared to that of the control group, was calculated using the 2 Yates corrected test or the Fisher exact test whenever appropriate. All the reported P values are two tailed.…”

Section: Discussionmentioning

confidence: 99%

“…Increasing evidence suggests that the hepatitis C virus (HCV) is the causative agent of the so-called mixed cryoglobulinemia (MC) [1][2][3][4] and that it might be involved in the pathogenesis of B cell non-Hodgkin's lymphomas (NHL) complicating MC 5,6 or arising 'de novo'. 7 On the basis of its prevalence among 537 patients with different lymphoproliferative disorders, 180 with MGUS (monoclonal gammopathy of unknown significance), and 470 with B cell NHL, we previously identified the B cell NHL (in particular the immunocytoma) associated with the production of cryoglobulins (in particular type II), as the probable pathogenetic target of HCV.…”

Section: Introductionmentioning

confidence: 99%

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The genotype of the hepatitis C virus in patients with HCV-related B cell non-Hodgkin’s lymphoma

et al. 1997

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Increasing evidence suggests that the hepatitis C virus (HCV) might be involved in the pathogenesis of B cell non-Hodgkin's lymphomas (NHL). Since several HCV genotypes are currently identifiable and might be involved in the pathogenesis of different diseases (with different severity and responsiveness to therapy), the aim of our study was to assess the prevalence of viral genotypes in a group of patients with HCV-related NHL. Among 470 consecutive patients, 42 HCV Ab-positive cases were identified. HCV RNA could be detected by reverse transcriptase-polymerase chain reaction and genotyping performed in 31 of these cases. As compared to our control group (211 healthy blood donors and patients with chronic liver disease), a striking high prevalence of genotype 2ac was detected among B cell NHL (48.4 vs 9.0%), with a relative risk of infection of 5.37 (P Ͻ 0.0001). No major differences were observed in the distribution of NHL histotypes and in the clinical features among patients with genotype 1b (the other most frequent genotype) or 2ac, a part from a trend towards a higher percentage of liver disease and a lower likelihood of response to interferon for patients with genotype 1b. The same high prevalence of genotype 2ac has been recently reported in patients with mixed cryoglobulinemia (MC), monoclonal gammopathies, B cell NHL complicating MC and autoimmune hepatitis. All these data taken together suggest that genotype 2ac might be involved in the pathogenesis of lymphoproliferative and autoimmune disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The genotype of the hepatitis C virus in patients with HCV-related B cell non-Hodgkin’s lymphoma

et al. 1997

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“…Recently a number of studies have implicated HCVinfection as the major cause of mixed cryoglobulinemia (2)(3)(4)(5)(6)(7). Patients with mixed cryoglobulinemia often showsymptoms associated with systemic vasculitis, such as purpura, arthralgia, peripheral neuropathy, and glomerulonephritis (GN).…”

Section: Introductionmentioning

confidence: 99%

Cryofiltration and Oral Corticosteroids Provide Successful Treatment for an Elderly Patient with Cryoglobulinemic Glomerulonephritis Associated with Hepatitis C Virus Infection.

et al. 2000

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A 75-year-old manwas admitted due to nephrotic syndrome, purpura on the legs, which was associated with hepatitis C virus (HCV), and type II mixed cryoglobulinemia. Renal biopsy revealed features of cryoglobulinemic glomerulonephritis. Since the patient was elderly and the HCV genotype was Ib, interferon-alpha for reducing HCVwas not indicated. Four sessions of cryofiltration and the administration of corticosteroids improved the proteinuria and renal function strikingly without adverse effects. This case demonstrates that an elderly patient who has nephrotic syndrome caused by cryoglobulinemic glomerulonephritis associated with HCVcan be treated safely by cryofiltration with low doses of oral corticosteroids.

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“…This hypothesis was definitely demonstrated in 1991, when the presence of HCV RNA was detected by means of polymerase chain reaction (PCR) in 86% of Italian MC patients [70]. Successively, an increasingly number of studies including clinico-epidemiological observations, as well as both histopathological and virological investigations (HCV RNA detection by PCR and/or in situ hybridization) have been definitely established the preeminent role of HCV in the pathogenesis of MC [8][9][10][11][12][13][14]21,25,59,[71][72][73][74][75][76].…”

Section: Etiopathogenesismentioning

confidence: 95%

“…MC was first described as distinct disorder in 1966 [5]; 25 years later the discovery of the strong association between MC and HCV infection [3,11,12,25,70] represented a decisive contribute for a better understanding of the etiopathogenetic mechanisms responsible for the disease, and consequently for an adequate therapeutic strategy.…”

Section: Unresolved Questionsmentioning

confidence: 99%