Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures

Mantegazza, Renato; Bernasconi, Pia; Baggi, Fulvio; Spreafico, Roberto; Ragona, Francesca; Antozzi, Carlo; Bernardi, Gaetano; Granata, Tiziana

doi:10.1016/s0165-5728(02)00261-8

Cited by 147 publications

(98 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GluR3 antikorları (serumda ve beyin omurilik sıvısın-da), RE ve inflamatuvar olmayan epilepsileri ayırt edemez. [6][7][8] Ayrıca, GluR3'ün varlığı veya yokluğu, spesifik patojen ile ilgili ipucu vermez. Bu nedenle spesifik tedavinin seçimi için kullanılmamalıdır.…”

Section: Laboratuvar Testleriunclassified

“…[2,3] Bununla birlikte, GluR3 antikorları (serumda ve beyin omurilik sıvısında), tüm RE hastalarda görülmediği gibi diğer dirençli epilepsilerde de bulunabildiği gösterilmiştir. [6][7][8] Bu nedenle, doku hasarına neden olmaktan çok, doku hasarına yanıt olduğu düşünülmüştür. Daha sonra, bir grup RE'li hastada α7 nikotinik asetilkolin reseptörlerine (α7nAChR) karşı serum IgG otoantikorlarınun bulunduğu bildirilmiş, nöronal α7nAChR fonksiyonunu (kan beyin bariyeri regülasyonunda rol oynayan inflamatuvar düzenleyici) spesifik olarak bloke ettiği ileri sürülmüştür.…”

Section: Introductionunclassified

See 1 more Smart Citation

Epileptic Syndromes With Possible Immunological Mechanisms (Rasmussen Encephalitis, FIRES, West Syndrome, Landau-Kleffner Syndrome)

Kınay¹

2015

Epilepsi

View full text Add to dashboard Cite

SummarySome of childhood epileptic syndromes reminds immunological etiologies with their good response to immuno-therapy and histopathological findings. These syndromes, such as Rasmussen encephalitis, FIRES, West syndrome, and Landau-Kleffner syndrome each of which are proceeding with severe epileptic encephalopathy are discussed with their physiopathological, clinical, EEG, laboratory, treatment and prognostic characteristics by the help of current literatüre.

show abstract

Section: Laboratuvar Testleriunclassified

Section: Introductionunclassified

Epileptic Syndromes With Possible Immunological Mechanisms (Rasmussen Encephalitis, FIRES, West Syndrome, Landau-Kleffner Syndrome)

Kınay¹

2015

Epilepsi

View full text Add to dashboard Cite

show abstract

“…GluR3, one subtype of antibodies to NMDA, was detected in the patients of 3 severe epilepsies: RE, noninflammatory focal epilepsy and "catastrophic" epilepsy [68-70]. With the development of the NMDAR antibody assay, now available worldwide, a few patients with classical limbic encephalitis(LE) and early psychosis and epilepsy have also been found to harbor these antibodies [71].…”

Section: Roles Of Immune and Inflammation In Drementioning

confidence: 99%

Modulation of Immunity and the Inflammatory Response: A New Target for Treating Drug-resistant Epilepsy

Líu²,

Qin³

2013

Current Neuropharmacology

View full text Add to dashboard Cite

Until recently, epilepsy medical therapy is usually limited to anti-epileptic drugs (AEDs). However, approximately 1/3 of epilepsy patients, described as drug-resistant epilepsy (DRE) patients, still suffer from continuous frequent seizures despite receiving adequate AEDs treatment of sufficient duration. More recently, with the remarkable progress of immunology, immunity and inflammation are considered to be key elements of the pathobiology of epilepsy. Activation of inflammatory processes in brain tissue has been observed in both experimental seizure animal models and epilepsy patients. Anti-inflammatory and immunotherapies also showed significant anticonvulsant properties both in clinical and in experimental settings. The above emerging evidence indicates that modulation of immunity and inflammatory processes could serve as novel specific targets to achieve potential anticonvulsant effects for the patients with epilepsy, especially DRE. Herein we review the recent evidence supporting the role of inflammation in the development and perpetuation of seizures, and also discuss the recent achievements in modulation of inflammation and immunotherapy applied to the treatment of epilepsy. Apart from medical therapy, we also discuss the influences of surgery, ketogenic diet, and electroconvulsive therapy on immunity and inflammation in DRE patients. Taken together, a promising perspective is suggested for future immunomodulatory therapies in the treatment of patients with DRE.

show abstract

“…Despite the presence of GluR3 antibodies in the serum, histology suggests that RE may be a T-cell mediated disease [273]. The diagnosis of RE is a clinical one, as the imaging and EEG findings are not specific, and the presence of GluR3 antibodies is neither specific nor sensitive [274]. Pathology generally shows changes consistent with chronic encephalitis (in various stages of active inflammation), findings which are also nonspecific.…”

Section: Rasmussen's Encephalitismentioning

confidence: 99%

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Geldern¹,

McPharlin

Becker

2012

Neurotherapeutics

View full text Add to dashboard Cite

This chapter will review the spectrum of immunemediated diseases that affect the nervous system and may result in an admission to the neurological intensive care unit. Immunomodulatory strategies to treat acute exacerbations of neurological diseases caused by aberrant immune responses are discussed, but strategies for long-term immunosuppression are not presented. The recommendations for therapeutic intervention are based on a synthesis of the literature, and include recommendations by the Cochrane Collaborative, the American Academy of Neurology, and other key organizations. References from recent publications are provided for the disorders and therapies in which randomized clinical trials and large evidenced-based reviews do not exist. The chapter concludes with a brief review of the mechanisms of action, dosing, and side effects of commonly used immunosuppressive strategies in the neurocritical care unit.

show abstract

Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures

Cited by 147 publications

References 16 publications

Epileptic Syndromes With Possible Immunological Mechanisms (Rasmussen Encephalitis, FIRES, West Syndrome, Landau-Kleffner Syndrome)

Epileptic Syndromes With Possible Immunological Mechanisms (Rasmussen Encephalitis, FIRES, West Syndrome, Landau-Kleffner Syndrome)

Modulation of Immunity and the Inflammatory Response: A New Target for Treating Drug-resistant Epilepsy

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Contact Info

Product

Resources

About