Antibodies against disialosyl and terminal NeuNAc(α2-3)Gal ganglioside epitopes in acute relapsing sensory ataxic neuropathy

Bulbar involvement in patients with antiganglioside antibodies against NeuNAc( 2-3)Gal

“…The epitope is shared by these three gangliosides and has been demonstrated in previous reports by means of inhibition studies 2 4 5…”

“…We have recently reported this pattern of reactivity in a patient with acute relapsing sensory ataxic neuropathy and bulbar involvement 5. Absorption studies confirmed this dual reactivity against the terminal NeuNAc(α2–3)Gal and disialosyl epitopes.…”

“…Furthermore, we reported concomitant reactivity against NeuNAc(α2–3)Gal and disialosyl epitopes in a patient with acute relapsing sensory ataxic neuropathy 5. Based on this case and the review of previously reported cases of chronic ataxic neuropathy,6 7 we suggested a correlation between NeuNAc(α2–3)Gal reactivity and bulbar involvement 5…”

“…Based on this case and the review of previously reported cases of chronic ataxic neuropathy,6 7 we suggested a correlation between NeuNAc(α2–3)Gal reactivity and bulbar involvement 5…”

“…ELISA identified simultaneous reactivity against GM3, GT1b and GD1a gangliosides in the sera of eight patients. Two of these, cases 1 and 8, have been reported elsewhere 4 5. Case 1 displayed an isolated reactivity against these three gangliosides.…”