Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity

Söderlin, Maria K.; Kastbom, Alf; Kautiainen, Hannu; Leirisalo‐Repo, Marjatta; Strandberg, Gunnar; Skogh, Thomas

doi:10.1080/03009740310004856

Cited by 46 publications

(30 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With regard to RA specificity, anti-citC1 III -P antibodies did not differ from anti-CCP autoantibodies, which could also be detected in very few patients suffering from rheumatic conditions other than RA, in good agreement with earlier studies [21,22]. In addition, the frequency of positive testing for anticitC1 III -P antibodies (40.4%) in our RA inception cohort was only slightly reduced compared to anti-CCP IgG results (49.8%) that confirmed published studies in early RA [23]. Accordingly, a significant correlation was obtained between serum anti-CCP-IgG and anti-citC1 III -P-IgG titers in the RA patients.…”

Section: Discussionsupporting

confidence: 92%

Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis

et al. 2005

View full text Add to dashboard Cite

Collagen type II (CII) is a relevant joint‐specific autoantigen in the pathogenesis of rheumatoid arthritis (RA). Whereas the reasons for the breakage of self tolerance to this major cartilage component are still enigmatic, T cell responses to glycosylated CII determinants in RA patients indicate that post‐translational modifications play a role. Since the conversion of arginine into citrulline by peptidylarginine deiminases (PAD) in some non‐joint‐specific antigens such as filaggrin or fibrin has been shown to give rise to RA‐specific humoral immune responses, we investigated whether PAD modification of cartilage‐specific CII might affect its recognition by circulating autoantibodies in early RA. In vitro treatment with purified PAD led to arginine deimination of native CII or of synthetic CII peptides as evidenced by amino acid analysis. The citrullination resulted in modified recognition of the immunodominant CII epitope C1III (amino acid residues 359–369) by murine and human antibodies. In a cohort of early RA patients (n=286), IgG antibodies directed toward a synthetic citrullinated C1III peptide (citC1III‐P) were detectable with a prevalence of 40.4%. The partial autoantibody cross‐reactivity between citC1III‐P and citrullinated peptides mimicking epitopes of the cytoskeletal autoantigen filaggrin suggests that autoimmunity to cartilage‐specific modified self might be a critical intermediate bridging recognition of PAD‐modified extra‐articular autoantigens with the disruption of tolerance to native cartilage constituents.

show abstract

Section: Discussionsupporting

confidence: 92%

Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis

et al. 2005

View full text Add to dashboard Cite

show abstract

“…A key posttranslational modification in autoimmunity appears to be the citrullination of arginine amino acid residues, by the enzymatic deimination of arginine to citrulline (Eggleton et al 2008;Doyle and Mamula 2012). This reaction is catalyzed by the enzyme peptidyl arginine deiminase (PAD) (Soderlin et al 2004). In multiple sclerosis and RA, citrullinated isoforms of myelin basic protein (Moscarello et al 2007) and fibrin (Masson-Bessiere et al 2001) have been found in the brain and synovia, respectively.…”

Section: Relationship With Other Autoimmune Diseases (Altered Antigens)mentioning

confidence: 99%

Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes

Pietropaolo

Towns

Eisenbarth

2012

Cold Spring Harbor Perspectives in Medicine

View full text Add to dashboard Cite

Type 1 diabetes mellitus (T1D) is an autoimmune disease encompassing the T-cell-mediated destruction of pancreatic b cells and the production of autoantibodies against islet proteins. In humoral autoimmunity in T1D, the detection of islet autoantibodies and the examination of their associations with genetic factors and cellular autoimmunity constitute major areas in both basic research and clinical practice. Although insulin is a key autoantigen and may be primus inter pares in importance among T1D autoantigens, an abundant body of research has also revealed other autoantigens associated with the disease process. Solid evidence indicates that autoantibodies against islet targets serve as key markers to enroll newly diagnosed T1D patients and their family members in intervention trials aimed at preventing or halting the disease process. The next challenge is perfecting mechanistic bioassays to be used as end points for disease amelioration following immunomodulatory therapies aimed at blocking immune-mediated b-cell injury and, in turn, preserving b-cell function in type 1 diabetes mellitus.

show abstract

“…[17][18][19] Recent studies have described the occurrence of anti-CCP in 41-68% of patients with early RA. [20][21][22][23][24][25][26] However, up to 90% of anti-CCP positive patients were also positive for RF 20 21 24 and cooccurrence of both antibodies was not more specific for RA than occurrence of either antibody alone. 25 27 Given this frequent concurrence of RF and anti-CCP as well as the economic impact of broad anti-CCP testing, we investigated if autoantibody profiling by sequential testing at first presentation might have diagnostic and prognostic value in differentiating RA from other arthritic disorders in an inception cohort of patients with very early inflammatory joint disease.…”

mentioning

confidence: 99%

Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis

Nell

Machold

Stamm

et al. 2005

Annals of the Rheumatic Diseases

298

213

View full text Add to dashboard Cite

Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity

Cited by 46 publications

References 5 publications

Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis

Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis

Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes

Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis

Contact Info

Product

Resources

About