Antibodies against 4-Hydroxy-2-nonenal Modified Epitopes Recognized Chromatin and Its Oxidized Forms: Role of Chromatin, Oxidized Forms of Chromatin and 4-Hydroxy-2-nonenal Modified Epitopes in the Etiopathogenesis of SLE

Al‐Shobaili, Hani A.; Robaee, Ahmad A. Al; Alzolibani, Abdullateef A.; Rasheed, Zafar

doi:10.1155/2012/532497

Cited by 26 publications

(21 citation statements)

References 37 publications

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“…Similarly, modification of individual nucleotide bases, single-strand breaks and cross-linking are the typical effects of ROS on nucleic acids. All these interactions of ROS with protein, lipid and nucleic acid are involved in auto-antibody formation in SLE patients [13,63]. Table 2 summarizes the important studies on antibodies formation against modified lipid, protein and DNA in SLE patients.…”

Section: Reviewmentioning

confidence: 99%

Oxidative stress and its biomarkers in systemic lupus erythematosus

et al. 2014

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Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease whose etiology remains largely unknown. The uncontrolled oxidative stress in SLE contributes to functional oxidative modifications of cellular protein, lipid and DNA and consequences of oxidative modification play a crucial role in immunomodulation and trigger autoimmunity. Measurements of oxidative modified protein, lipid and DNA in biological samples from SLE patients may assist in the elucidation of the pathophysiological mechanisms of the oxidative stress-related damage, the prediction of disease prognosis and the selection of adequate treatment in the early stage of disease. Application of these biomarkers in disease may indicate the early effectiveness of the therapy. This review is intended to provide an overview of various reactive oxygen species (ROS) formed during the state of disease and their biomarkers linking with disease. The first part of the review presents biochemistry and pathophysiology of ROS and antioxidant system in disease. The second part of the review discusses the recent development of oxidative stress biomarkers that relates pathogenesis in SLE patients and animal model. Finally, this review also describes the reported clinical trials of antioxidant in the disease that have evaluated the efficacy of antioxidant in the management of disease with ongoing conventional therapy.

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Section: Reviewmentioning

confidence: 99%

Oxidative stress and its biomarkers in systemic lupus erythematosus

et al. 2014

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“…It is characterized by the production of autoantibodies against self-antigens that form immune complex deposits [1,2]. The prevalence of SLE varies from 20 to 150 cases per 100,000 with a high prevalence in women (9:1) [3].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles as Therapeutic Agents in Systemic Lupus Erythematosus

Perez-Hernandez¹,

Redón²,

Cortés³

2017

IJMS

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Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that affects multiple organs. Currently, therapeutic molecules present adverse side effects and are only effective in some SLE patient subgroups. Extracellular vesicles (EV), including exosomes, microvesicles and apoptotic bodies, are released by most cell types, carry nucleic acids, proteins and lipids and play a crucial role in cell-to-cell communication. EVs can stimulate or suppress the immune responses depending on the context. In SLE, EVs can work as autoadjuvants, enhance immune complex formation and maintaining inflammation state. Over the last years, EVs derived from mesenchymal stem cells and antigen presenting cells have emerged as cell-free therapeutic agents to treat autoimmune and inflammatory diseases. In this review, we summarize the current therapeutic applications of extracellular vesicles to regulate immune responses and to ameliorate disease activity in SLE and other autoimmune disorders.

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“…Essentially, adjustment of individual nucleotide bases, single-strand breaks and cross-connecting are regular impacts of ROS on nucleic acids. All these communications of ROS with protein, lipid and nucleic corrosive prompts the development of adducts items which are exceedingly immunogenic and are perceived as an outside molecule to our body, which may be included in arrangement of pathogenic auto-immune response in SLE [30,31].…”

Section: Mechanism Of Oxidative Damagementioning

confidence: 99%