Antibiotics with therapeutic effects on spinal cord injury: a review

Abstract

Accumulating evidence indicates that a considerable number of antibiotics exert anti‐inflammatory and neuroprotective effects in different central and peripheral nervous system diseases including spinal cord injury (SCI). Both clinical and preclinical studies on SCI have found therapeutic effects of antibiotics from different families on SCI. These include macrolides, minocycline, β‐lactams, and dapsone, all of which have been found to improve SCI sequels and complications. These antibiotics may target similar signaling pathways such as reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating the SCI‐related mitochondrial dysfunction. In this review paper, we will discuss the mechanisms underlying therapeutic effects of these antibiotics on SCI, which not only could supply vital information for investigators but also guide clinicians to consider administering these antibiotics as part of a multimodal therapeutic approach for management of SCI and its complications.

Dapsone, More than an Effective Neuro and Cytoprotective Drug

“…3 ). This review provides information on the role of dapsone in translational medicine to manage SCI and its complications [ 125 ].…”

Epidemiological Study on Spinal Cord Injuries in a Hospital from North-West of Romania

“…The spinal cord is organized into thirty-one pairs of spinal nerves. A spinal cord injury disrupts this symbiosis between body and brain and can cause deficits in sensation, movement, and autonomic regulation, as well as death [10][11][12]. Control of the gastrointestinal system involves complex interactions between autonomic and somatic innervation ultimately acting on the intrinsic enteric nervous system.…”