Antibiotics Resistance Prevalence of Helicobacter pylori Strains in Northwest China

Xu, Huimei; Yun, Jianwei; Li, Ruiying; Ma, Xueni; Gou, Lingzhu; Che, Tuanjie; Zhang, Dekui

doi:10.2147/idr.s383444

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…13 Some other studies reported a notably high secondary resistance rate to AMX, which indicated that previous treatment failure could be associated with AMX resistance. 31,38 In addition, the peptic ulcer seems a protective factor for the CLA and LEV resistance in this study. Patients with a peptic ulcer may have a timely treatment because of various symptoms and reduce the chance of biofilm formation which could resulted in antibiotic resistance.…”

Section: F I G U R Esupporting

confidence: 51%

Treatment failure is a key factor in the development of Helicobacter pylori resistance

Xie,

Peng,

Liu

et al. 2024

Helicobacter

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BackgroundHelicobacter pylori eradication failure influences its antibiotic resistance.AimsThis study aimed to evaluate the effect of previous treatment failures on it, including the changes in the antibiotic resistance rates, minimal inhibitory concentration (MIC) distributions, and resistance patterns.Materials and MethodsThis single‐center retrospective study included 860 primary isolates and 247 secondary isolates. Antibiotic susceptibility testing was performed for amoxicillin, metronidazole, clarithromycin, levofloxacin, furazolidone, tetracycline, and rifampicin. The demographic data and detailed regimens were collected.ResultsThe primary resistance rates to amoxicillin, metronidazole, clarithromycin, levofloxacin, tetracycline, rifampin, and furazolidone were 5.93%, 83.84%, 28.82%, 26.28%, 0.35%, 1.16%, and 0%, while secondary were 25.10%, 92.31%, 79.76%, 63.16%, 1.06%, 3.19%, and 0%, respectively. The resistance rates to amoxicillin, metronidazole, clarithromycin, and levofloxacin increased significantly with the number of treatment failures accumulated, and showed a linear trend. The proportion of primary and secondary multidrug‐resistant (MDR) isolates were 17.79% and 63.16%, respectively. The MIC values of amoxicillin, clarithromycin, and levofloxacin were elevated significantly with medication courses increased.ConclusionThe prevalence of amoxicillin, clarithromycin, levofloxacin, and metronidazole resistance would increase rapidly following first‐line treatment failure, as well as the MIC values of them. Clinicians should pay great attention to the first‐line treatment to cure H. pylori infection successfully.

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Section: F I G U R Esupporting

confidence: 51%

Treatment failure is a key factor in the development of Helicobacter pylori resistance

Xie,

Peng,

Liu

et al. 2024

Helicobacter

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“…These results are consistent with a previous study conducted in northwest China. 15 Conversely, a study conducted in Chile reported an increase in the prevalence of LEV resistance with age in both men and women. 16 Notably, we did not observe a statistically significant difference in the prevalence of CLA resistance across different age groups.…”

Section: Discussionmentioning

confidence: 95%

Prevalence of Helicobacter pylori Antibiotic Resistance in Patients Enrolled in Guangzhou, China

Deng¹,

Liu²,

Xie³

et al. 2023

IDR

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Purpose Helicobacter pylori ( H. pylori ) infection is a high-risk factor for the occurrence of gastric cancer. The quadruple therapy has been widely used as the first-line treatment for H. pylori in China. However, the increasing resistance rate to antibiotics has become a major challenge in the treatment of H. pylori . Therefore, there is an urgent need for rapid and cost-effective detection of antibiotic resistance to different antibiotics. To evaluate the prevalence of H. pylori antibiotic resistance in Guangzhou and the diagnostic performance of DOB value of 13C UBT in predicting antibiotic resistance. Patients and Methods In this retrospective study, we collected data from 193 H. pylori culture-positive patients in Guangzhou on their DOB values and resistance to antibiotics. We analyzed the antibiotic resistance rate of commonly used antibiotics in quadruple therapy, and the diagnostic efficacy of DOB value was evaluated. Results The resistance rates of clarithromycin (CLA) and levofloxacin (LEV) were 46.1% and 44.0%, respectively. In the age group under 40, the resistance rate of LEV was lower than that of CLA. However, the diagnostic efficacy of DOB value was found to be low and it could not serve as an independent indicator for diagnosing resistance to CLA and LEV. Conclusion The high resistance rates of CLA and LEV in H. pylori patients in Guangzhou indicate the urgent need for effective detection methods. The DOB value is not a direct indicator of antibiotic resistance to CLA and LEV. Therefore, it is important to use a combination of diagnostic methods to accurately assess antibiotic resistance in H. pylori infection.

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“…China, too, confronts a significant challenge of antibiotic resistance, which presents grave implications for the effective treatment of H. pylori infections. (Zhong et al, 2021;Xu et al, 2022) Despite recent studies suggesting that high-dose dual therapy (HDDT) demonstrates similar effectiveness and adherence compared to bismuth-containing quadruple therapy (BQT) or standard triple treatment, BQT remains the predominant treatment approach for H. pylori infection in China (Chey et al, 2022;Zou et al, 2022). Nanjing, situated in eastern China, is a metropolis with a populace exceeding 10 million.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance of Helicobacter pylori in Nanjing, China: a cross-section study from 2018 to 2023

Wei,

Wang,

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundThe increasing prevalence of antibiotic resistance in cases of Helicobacter pylori (H. pylori) infection has emerged as a significant global issue. This study offers a comprehensive examination of the alterations in drug resistance exhibited by H. pylori in the Nanjing region of China during the preceding five years. Another important objective is to investigate the influence of levofloxacin medication history on genotypic and phenotypic resistance.MethodsThis research screened 4277 individuals diagnosed with H. pylori infection between April 2018 and May 2023. The phenotype and genotypic resistance were evaluated using the Kirby-Bauer disk diffusion and PCR method.ResultsThe most recent primary resistance rates for metronidazole, clarithromycin, levofloxacin, amoxicillin, furazolidone, and tetracycline were recorded at 77.23% (2385/3088), 37.24% (1150/3088), 27.72% (856/3088), 0.52% (16/3088), 0.19% (6/3088), and 0.06% (2/3088), respectively. For the recent five years, we observed a notable upsurge in the rate of metronidazole resistance and a slight elevation of clarithromycin and levofloxacin resistance. The documented resistance rates to single-drug, dual-drug, triple-drug, and quadruple-drug regimens were 35.39%, 28.32%, 25.72%, and 0.21%, respectively. The prevalence of multidrug-resistant strains escalated, rising from 37.96% in 2018 to 66.22% in 2023. The rate of phenotypic and genotypic resistance rate (57.10% and 65.57%) observed in strains obtained from patients without a levofloxacin treatment history was significantly lower than the rate in strains obtained from those with a history of levofloxacin treatment (88.73% and 94.74%). The prevailing gyrA mutations were primarily N87K (52.35%, 345/659), accompanied by D91N (13.96%, 92/659), and closely followed by D87G (10.77%, 71/659). For gyrA mutations, the 91-amino acid mutants exhibit a higher likelihood of discrepancies between phenotypic and genotypic resistance than the 87-amino acid mutants.ConclusionThe extent of antibiotic resistance within H. pylori remains substantial within the Nanjing region. If levofloxacin proves ineffective in eradicating H. pylori during the initial treatment, its use in subsequent treatments is discouraged. The employment of levofloxacin resistance genotype testing can partially substitute conventional antibiotic sensitivity testing. Notably, predicting phenotypic resistance of levofloxacin through PCR requires more attention to the mutation type of gyrA to improve prediction accuracy.

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Antibiotics Resistance Prevalence of Helicobacter pylori Strains in Northwest China

Cited by 11 publications

References 21 publications

Treatment failure is a key factor in the development of Helicobacter pylori resistance

Treatment failure is a key factor in the development of Helicobacter pylori resistance

Prevalence of Helicobacter pylori Antibiotic Resistance in Patients Enrolled in Guangzhou, China

Antibiotic resistance of Helicobacter pylori in Nanjing, China: a cross-section study from 2018 to 2023

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