Antibiotics inhibiting the biosynthesis of cholesterol (a review)

Тренин, А. С.; Катруха, Г. С.

doi:10.1007/bf02464303

Cited by 2 publications

(1 citation statement)

References 108 publications

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“…5). It is the hydroxy acid opened lactone structure which is active for inhibition of HMG-CoA reductase (Albert 1980;Trenin and Katruhha 1997). The b-hydroxy acid contributed to a competitive inhibition of HMG-CoA reductase and the production of cholesterol.…”

Section: Monacolins In Red Yeast Ricementioning

confidence: 99%

The presence and the content of Monacolins in Red Yeast rice prepared from Thai glutinous rice

Chairote

Niamsup

et al. 2008

World J Microbiol Biotechnol

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Red yeast rice which is a product of solid fermentation was prepared from several kinds of Thai glutinous rice (Oryza sativa L.) cv. Korkor 6 (RD6), Kam (Kam), and Sanpatong1 (SPT1). Monascus purpureus CMU001 isolated from available Chinese red yeast rice was used as the fermentation starter. The analysis for the presence and the content of monacolins, the cholesterollowering compounds, were carried out using high performance liquid chromatography (HPLC). The presence of the monacolins was confirmed by the retention time of the reference compounds and LC-MS. The results were compared to those obtained from the Chinese red yeast rice and Thai non-glutinous rice (O. sativa L. cv. Mali105). The chromatograms show the presence of monacolin K acid form (MKA), compactin (P1), monacolin M acid form (MMA), monacolin K (MK), monacolin M (MM), and dehydromonacolin K (DMK). A large peak of a compound with the molecular weight of 358 was also detected but could not be identified. The amount of two important monacolins, compactin, and monacolin K, were determined. It was found that the highest amount of compactin and monacolin K were 21.98 and 33.79 mg/g, respectively, when using Thai rice varity O. sativa L. cv. RD6 which was fermented without adding soybean milk.

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Section: Monacolins In Red Yeast Ricementioning

confidence: 99%

The presence and the content of Monacolins in Red Yeast rice prepared from Thai glutinous rice

Chairote

Niamsup

et al. 2008

World J Microbiol Biotechnol

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Enzymatic Synthesis of a Key Intermediate for Rosuvastatin by Nitrilase‐Catalyzed Hydrolysis of Ethyl (R)‐4‐Cyano‐3‐hydroxybutyate at High Substrate Concentration

Yao¹,

Li²,

Yuan³

et al. 2014

ChemCatChem

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An enzymatic method for the synthesis of ethyl (R)‐3‐hydroxyglutarate from ethyl (R)‐4‐cyano‐3‐hydroxybutyate was developed by using free and immobilized recombinant Escherichia coli BL21(DE3)pLysS harboring a nitrilase gene from Arabidopsis thaliana (AtNIT2). The hydrolysis of ethyl (R)‐4‐cyano‐3‐hydroxybutyate proceeded with the freely suspended cells of the biocatalyst under the optimized conditions of 1.5 mol L−1 (235.5 g L−1) substrate concentration and 6.0 wt % loading of wet cells at pH 8.0 and 25 °C, with 100 % conversion obtained in 4.5 h. Furthermore, immobilization of the whole cells enhanced their substrate tolerance, stability, and reusability. Under the optimized conditions (100 mmol L−1 tris(hydroxymethyl)aminomethane hydrochloride buffer, pH 8.0, 25 °C), the immobilized biocatalyst could be reused for up to 16 batches, with a biocatalyst productivity of 55.6 g gwet cells−1 and a space‐time productivity of 625.5 g L−1 d−1. These results demonstrated that the immobilized whole cells might be used as a biocatalyst in the industrial production of ethyl (R)‐3‐hydroxyglutarate, a key intermediate for the synthesis of rosuvastatin.

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Antibiotics inhibiting the biosynthesis of cholesterol (a review)

Cited by 2 publications

References 108 publications

The presence and the content of Monacolins in Red Yeast rice prepared from Thai glutinous rice

The presence and the content of Monacolins in Red Yeast rice prepared from Thai glutinous rice

Enzymatic Synthesis of a Key Intermediate for Rosuvastatin by Nitrilase‐Catalyzed Hydrolysis of Ethyl (R)‐4‐Cyano‐3‐hydroxybutyate at High Substrate Concentration

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