Antibiotics increase aggression behavior and aggression-related pheromones and receptors in Drosophila melanogaster

Grinberg, Mor; Levin, R.; Neuman, Hadar; Ziv, Oren; Turjeman, Sondra; Gamliel, Gila; Nosenko, Rita; Koren, Omry

doi:10.1016/j.isci.2022.104371

Cited by 9 publications

(6 citation statements)

References 38 publications

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“…The impact of changes in microbial composition on aggression is still unclear though, as one study found that an absence of bacteria led to decreased aggression in fruit flies (13). Similar findings have been made in hamsters (14), but several studies revealed increased aggression following antibiotic treatment or in germ-free settings (8,10,11). Many of these published studies are preliminary or descriptive, and to date, none have uncovered mechanisms or even explained the network of interactions between aggression, hormone levels, gene expression, metabolite profiles, and gut microbiome.…”

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confidence: 85%

“…Numerous studies have provided evidence supporting the notion of a gut-brain axis, with crosstalk mediated by the microbiome( 6 ). While research on the role of the microbiome in aggression is in its infancy, connections have been identified in Drosophila melanogaster ( 8 ), dogs( 9 ), mice( 10, 11 ), and humans( 12 ). The impact of changes in microbial composition on aggression is still unclear though, as one study found that an absence of bacteria led to decreased aggression in fruit flies( 13 ).…”

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confidence: 99%

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Aggression: A gut reaction? The effects of the gut microbiome on aggression

Uzan-Yulzari,

Turjeman,

Getselter

et al. 2023

Preprint

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Recent research has unveiled conflicting evidence regarding the link between aggression and the gut microbiome. In our investigation, we meticulously examined the behavioral patterns of four groups of mice – wild-type, germ-free (GF), mice treated with antibiotics, and recolonized GF mice – to gain mechanistic insights into the impact of the gut microbiome on aggression. We discovered a significant correlation between diminished microbiome and increased aggression. Importantly, this behavioral shift could be restored when a WT microbiota was reinstated. Microbiota manipulation also significantly altered brain function, particularly in aggression-associated genes, and urine metabolite profiles. Notably, our study extends beyond the murine model, shedding light on clinical implications of early-life antibiotic exposure. We found that fecal microbiome transplants from 1mo old infants prescribed antibiotics during their first days of life led to a marked increase in aggression in recipient mice. This research demonstrates that the microbiota modulates aggression and underscores its importance in the realm of behavioral science.One-Sentence SummaryThe antibiotic-altered gut microbiome is implicated in increased aggression. It also leads to altered brain function, particularly in genes linked to aggression, and urine metabolite profiles showing a multi-system response to microbiota disruption.

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confidence: 85%

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confidence: 99%

Aggression: A gut reaction? The effects of the gut microbiome on aggression

Uzan-Yulzari,

Turjeman,

Getselter

et al. 2023

Preprint

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“…Grinberg et al [59] investigated the association between aggression and the gut environment in male Drosophila by comparing flies grown on media supplemented with a mixture of antibiotics (Abx), Lactobacillus brevis (L. brevis)-monocolonized flies, Lactobacillus plantarum (L. plantarum)-monocolonized flies, and untreated flies (n = 8 for each). The Abx treatment significantly increased the number of aggressive encounters among male flies by nearly 150% compared with that of the control group, whereas supplementation with a single bacterial species (L. plantarum or L. brevis) significantly reduced aggression, compared with that seen in Abx-treated flies.…”

Section: Drosophilamentioning

confidence: 99%

Impact of Gut Microbiota on Host Aggression: Potential Applications for Therapeutic Interventions Early in Development

et al. 2023

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Aggression in the animal kingdom is a necessary component of life; however, certain forms of aggression, especially in humans, are pathological behaviors that are detrimental to society. Animal models have been used to study a number of factors, including brain morphology, neuropeptides, alcohol consumption, and early life circumstances, to unravel the mechanisms underlying aggression. These animal models have shown validity as experimental models. Moreover, recent studies using mouse, dog, hamster, and drosophila models have indicated that aggression may be affected by the “microbiota–gut–brain axis.” Disturbing the gut microbiota of pregnant animals increases aggression in their offspring. In addition, behavioral analyses using germ-free mice have shown that manipulating the intestinal microbiota during early development suppresses aggression. These studies suggest that treating the host gut microbiota during early development is critical. However, few clinical studies have investigated gut-microbiota-targeted treatments with aggression as a primary endpoint. This review aims to clarify the effects of gut microbiota on aggression and discusses the therapeutic potential of regulating human aggression by intervening in gut microbiota.

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“…Beyond diet and metabolism, HA microbiomes influence a range of other host traits as well (Archie & Theis, 2011;Bravo et al, 2011;Davidson et al, 2018;Ezenwa et al, 2012;Gaona et al, 2016;Grinberg et al, 2022;Jia et al, 2021;Kirchoff et al, 2019;Neufeld et al, 2011;Sampson & Mazmanian, 2015;Sharon et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Gut microbiomes can also be important determinants of dietary niche (Blyton et al., 2019; Greene et al., 2020; Heys et al., 2021; Kohl et al., 2014; Moeller & Sanders, 2020), either by provisioning hosts with key nutrients (Hu et al., 2018; Jing et al., 2020; Ju et al., 2020) or by detoxifying defensive compounds found in host food sources (Zheng et al., 2016). Beyond diet and metabolism, HA microbiomes influence a range of other host traits as well (Archie & Theis, 2011; Bravo et al., 2011; Davidson et al., 2018; Ezenwa et al., 2012; Gaona et al., 2016; Grinberg et al., 2022; Jia et al., 2021; Kirchoff et al., 2019; Neufeld et al., 2011; Sampson & Mazmanian, 2015; Sharon et al., 2010). Healthy gut (Chen et al., 2018; Kamada et al., 2013), skin (Chen et al., 2018; Harris et al., 2006; Kueneman et al., 2014) and vaginal microbiomes (Brotman et al., 2010), for example, provide pathogen resistance across a broad spectrum of animal species (Buffie & Pamer, 2013; Ubeda et al., 2017; Woodhams et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

A conceptual framework for host‐associated microbiomes of hybrid organisms

Camper,

Laughlin,

Malagon

et al. 2024

Methods Ecol Evol

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Hybridization between organisms from evolutionarily distinct lineages can have profound consequences on organismal ecology, with cascading effects on fitness and evolution. Most studies of hybrid organisms have focused on organismal traits, for example, various aspects of morphology and physiology. However, with the recent emergence of holobiont theory, there has been growing interest in understanding how hybridization impacts and is impacted by host‐associated microbiomes. Better understanding of the interplay between host hybridization and host‐associated microbiomes has the potential to provide insight into both the roles of host‐associated microbiomes as dictators of host performance as well as the fundamental rules governing host‐associated microbiome assembly. Unfortunately, there is a current lack of frameworks for understanding the structure of host‐associated microbiomes of hybrid organisms. In this paper, we develop four conceptual models describing possible relationships between the host‐associated microbiomes of hybrids and their progenitor or ‘parent’ taxa. We then integrate these models into a quantitative ‘4H index’ and present a new R package for calculation, visualization and analysis of this index. We demonstrate how the 4H index can be used to compare hybrid microbiomes across disparate plant and animal systems. Our analyses of these data sets show variation in the 4H index across systems based on host taxonomy, host site and microbial taxonomic group. Our four conceptual models, paired with our 4H index and associated visualization tools, facilitate comparison across hybrid systems. This, in turn, allows for systematic exploration of how different aspects of host hybridization impact the host‐associated microbiomes of hybrid organisms.

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Antibiotics increase aggression behavior and aggression-related pheromones and receptors in Drosophila melanogaster

Cited by 9 publications

References 38 publications

Aggression: A gut reaction? The effects of the gut microbiome on aggression

Aggression: A gut reaction? The effects of the gut microbiome on aggression

Impact of Gut Microbiota on Host Aggression: Potential Applications for Therapeutic Interventions Early in Development

A conceptual framework for host‐associated microbiomes of hybrid organisms

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