Antibiotics in the first week of life is a risk factor for allergic rhinitis at school age

Alm, Bernt; Goksör, Emma; Pettersson, Robert; Möllborg, Per; Erdes, Laslo; Loid, Petra; Åberg, Nils; Wennergren, Göran

doi:10.1111/pai.12244

Cited by 51 publications

(51 citation statements)

References 30 publications

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“…. Furthermore, a prospective study of Swedish children revealed that antibiotics during the first week of life increased the risk of developing allergic rhinitis by 8 years of age while living on a farm during childhood was protective …”

Section: Other Allergies: Allergic Rhinitis Atopic Dermatitis and Ementioning

confidence: 99%

The nutrition‐gut microbiome‐physiology axis and allergic diseases

McKenzie

Tan

Macia

et al. 2017

Immunological Reviews

236

202

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Dietary and bacterial metabolites influence immune responses. This raises the question whether the increased incidence of allergies, asthma, some autoimmune diseases, cardiovascular disease, and others might relate to intake of unhealthy foods, and the decreased intake of dietary fiber. In recent years, new knowledge on the molecular mechanisms underpinning a 'diet-gut microbiota-physiology axis' has emerged to substantiate this idea. Fiber is fermented to short chain fatty acids (SCFAs), particularly acetate, butyrate, and propionate. These metabolites bind 'metabolite-sensing' G-protein-coupled receptors such as GPR43, GPR41, and GPR109A. These receptors play fundamental roles in the promotion of gut homeostasis and the regulation of inflammatory responses. For instance, these receptors and their metabolites influence Treg biology, epithelial integrity, gut homeostasis, DC biology, and IgA antibody responses. The SCFAs also influence gene transcription in many cells and tissues, through their inhibition of histone deacetylase expression or function. Contained in this mix is the gut microbiome, as commensal bacteria in the gut have the necessary enzymes to digest dietary fiber to SCFAs, and dysbiosis in the gut may affect the production of SCFAs and their distribution to tissues throughout the body. SCFAs can epigenetically modify DNA, and so may be one mechanism to account for diseases with a 'developmental origin', whereby in utero or post-natal exposure to environmental factors (such as nutrition of the mother) may account for disease later in life. If the nutrition-gut microbiome-physiology axis does underpin at least some of the Western lifestyle influence on asthma and allergies, then there is tremendous scope to correct this with healthy foodstuffs, probiotics, and prebiotics.

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Section: Other Allergies: Allergic Rhinitis Atopic Dermatitis and Ementioning

confidence: 99%

The nutrition‐gut microbiome‐physiology axis and allergic diseases

McKenzie

Tan

Macia

et al. 2017

Immunological Reviews

236

202

View full text Add to dashboard Cite

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“…Only 11 of 34 studies included explicitly reported that the use of antibiotics preceded the diagnosis of allergies. 10,12,16,18,21,[25][26][27]37,38,43 In our meta-analysis, we tested the association between antibiotics and risk of hay fever and eczema only in these 11 studies to infer causality and the results still showed a significant association.…”

Section: -56mentioning

confidence: 99%

Early‐life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta‐analysis

Ahmadizar

Vijverberg

Arets

et al. 2017

Allergy

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This study systematically reviewed and quantified the relationship between exposure to antibiotics during the first 2 years of life and the risk of allergies/atopies including hay fever, eczema, food allergy, positive skin prick testing (SPT), or elevated allergen-specific serum/plasma immunoglobulin (Ig) E levels later in life.PubMed and Web of Science databases were searched for observational studies published from January 1966 through November 11, 2015. Overall pooled estimates of the odds ratios (ORs) were obtained using fixed or random-effects models. Earlylife exposure to antibiotics appears to be related to an increased risk of allergic symptoms of hay fever, eczema, and food allergy later in life. The summary OR for the risk of hay fever (22 studies Early-life exposure to antibiotics has been related to some later life morbidities such as obesity, arthritis, asthma, and allergies. 6,7 A meta-analysis from 2006 showed a higher risk of asthma among those children exposed to antibiotics in early childhood. 8 However, a more recent meta-analysis from 2011 reported that the association between antibiotics exposure and subsequent development of wheeze/asthma was weak when the analysis was adjusted for reverse causation and confounding by indication. 9Several studies have suggested that early-life exposure to antibiotics is associated with an increased risk of developing allergies and atopies later in life, but results are inconsistent. Therefore, the aim of this study was to conduct a systematic review and meta-analysis to assess and quantify the relationship between early-life exposure to antibiotics and the risk of developing symptoms of hay fever, eczema, food allergy, positive skin prick testing (SPT), or elevated allergen-specific serum/plasma immunoglobulin (Ig) E levels later in life.Abbreviations: CI, confidence interval; HR, hazard ratio; IgE, immunoglobulin E; OR, odds ratio; SPT, skin prick test.

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“…[61][62][63] İlaç (ateş düşürücü ve antibiyotik) kullanımı: İlk yaşta sık (ayda bir) parasetamol kullanımı ve süt çocuğunda yılda dört kere veya fazla antibiyotik kullanımı AR riskini artırmaktadır. [64] Elli ülke, 113 merkezde, 322.959 ergende yapılan çalışmada asetaminofen kullanımının rino-konjonktivit riskini artırdığı gösterilmiştir. [65] Çocukluk çağı aşıları: Çocukluk çağı viral aşı-larının (DTP, kızamık, suçiçeği ve MMR vb.)…”

Section: çOcukluk çAğı Enfeksiyonlarıunclassified

Variable prevalence of allergic rhinitis and risk factors affecting the prevalence

Özdemir

Elmas²

2016

Kulak Burun Bogaz Ihtis Derg

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ÖZAlerjik rinit burunda akıntı, hapşırık, kaşıntı ve tıkanıklık, sıklıkla konjonktival enjeksiyon ve gözde kaşınmayla karakterize olan burun mukozasının kronik enflamasyonu olarak tanımlanmaktadır. Çocukluk çağı alerjik rinit prevalansı dünya çapında hızlı bir artış göstermektedir. Ancak bölgeler arasında bariz farklar vardır, bu da alerjik rinitin gelişiminde değişen genetik ve çevresel etkenlere işaret etmektedir. Bölgesel bu fark, genetik yatkınlık yanında çevresel ve davranışsal faktörlerin hızlı değişimiyle meydana gelen 'Batı tarzı diyet' ve 'Batılı yaşam tarzı' ile esas olarak ilişkili bulunmuştur. Alerjik rinit gelişimine yol açan bazı ana ve potansiyel risk faktörleri halen net olarak bilinmemektedir. Bu derlemede, çoğu iyi bilinen ve bazı yeni ortaya çıkmış risk faktörleri son literatür verileri ışığında tartışılacaktır.Anahtar Sözcükler: Allerjik rinit; prevalans; risk faktörü. ABSTRACTAllergic rhinitis is described as a chronic inflammation of the nasal mucosa causing rhinorrhea, sneezing, nasal congestion and itching, often characterized with conjunctival injection and ocular itching. The prevalence of pediatric allergic rhinitis has recently shown a sharp increase throughout the world. However, there are significant differences among the regions, thus indicating to the influence of varying genetic and environmental factors upon the development of allergic rhinitis. This regional difference is mainly related to the 'western diet' and 'western lifestyle', with its swift changes in environmental and behavioral factors, besides a genetic predisposition. Some main and potential risk factors contributing to the development of allergic rhinitis are still unclear. In this review, we discuss mostly well known and some emerging new risk factors in the light of recent literature.

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Antibiotics in the first week of life is a risk factor for allergic rhinitis at school age

Cited by 51 publications

References 30 publications

The nutrition‐gut microbiome‐physiology axis and allergic diseases

The nutrition‐gut microbiome‐physiology axis and allergic diseases

Early‐life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta‐analysis

Variable prevalence of allergic rhinitis and risk factors affecting the prevalence

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