Antibiotics in pregnancy: analysis of potential risks and determinants in a large German statutory sickness fund population

Amann, Ute; Egen-Lappe, Veronika; Strunz-Lehner, Christine; Hasford, Joerg

doi:10.1002/pds.1225

Cited by 53 publications

(83 citation statements)

References 27 publications

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“…The most prescribed antibiotic drugs were B-lactam antibacterials and penicillins, and we observed strong decline in dispensed antibiotics not recommended during pregnancy. Similar findings were reported in a Norwegian5 and a German25 study. Among women with a dispensed antibiotic drug from 90 days before first visit to antenatal care, only 20% reported this intake according to the medical records.…”

Section: Discussionsupporting

confidence: 90%

Drug use during pregnancy in Sweden – assessed by the Prescribed Drug Register and the Medical Birth Register

Stephansson¹,

Granath²,

Svensson³

et al. 2011

CLEP

158

167

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Purpose:The purpose of this research is to study drug use during pregnancy in Sweden and agreement between use according to antenatal medical records and dispensed drugs from a pharmacy database.Patients and methods:From the Swedish Medical Birth Register (MBR), we established a population-based cohort of 102,995 women who gave birth in 2007. Using the unique personal registration number, information on dispensed drugs from the Prescribed Drug Register (PDR) was obtained prior to, during, and after the pregnancies and compared with MBR information on drug use from standardized antenatal medical records.Results:According to the PDR, 57.6% of the 102,995 women filled a prescription with at least one drug during pregnancy and 50.9% during the lactating period (until 3 months after delivery). The most dispensed drugs during pregnancy were B-lactam antibacterials and penicillins. Agreement between drugs recorded in antenatal medical records and dispensed drugs was highest for drugs used for chronic conditions. The agreement was particularly high for thyroid therapy (85.3%), anti-intestinal inflammatory drugs (80.3%), antiepileptics (69.2%), immunosuppressants (67.4%), and insulin (63.8%). Agreement for drugs used for occasional use was generally lower, ranging between 42.5% for antihistamines and 0.8% for gynecological anti-infectives.Conclusions:A large proportion of women filled a prescription during pregnancy or the lactating period. Agreement between drug use in medical antenatal records and register information from a national pharmacy database was high for drugs used for chronic conditions but low for occasional use. For occasionally used drugs, medical record and register-based data may provide incomplete exposure information because of nonreporting or noncompliance.

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Section: Discussionsupporting

confidence: 90%

Drug use during pregnancy in Sweden – assessed by the Prescribed Drug Register and the Medical Birth Register

Stephansson¹,

Granath²,

Svensson³

et al. 2011

CLEP

158

167

View full text Add to dashboard Cite

show abstract

“…This observation was confirmed in our study. The German researchers attributed higher use of antibiotics by younger pregnant women to higher rates of infections in this age group 27. Screening for bacteriuria as part of routine examination of pregnant women was introduced in Denmark in 1998,22,23 probably partially explaining our observation of increased use of UTI-specific drugs among women giving first birth throughout the study period.…”

Section: Discussionmentioning

confidence: 80%

Use of prescribed drugs among primiparous women: an 11-year population-based study in Denmark

Bjørn¹,

Nørgaard²,

Hundborg³

et al. 2011

CLEP

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Purpose:To describe patterns of prescribed drug use over time among primiparous women in Denmark.Methods:Through the Danish Medical Birth Registry, we identified all primiparous women giving live birth or stillbirth at ≥ 22 gestational weeks in northern Denmark, from 1999 to 2009. From the Aarhus University Prescription Database we obtained information on the women’s prescriptions for reimbursed drugs filled from 30 days before conception until delivery.Results:Among 85,710 primiparous women, 47,982 (56.0%) redeemed at least one prescription from 30 days before conception until delivery. Women aged 35 years and older had the highest overall prevalence of prescription drug use (61.1%). Age-standardized prevalence of drug use was 54.7% in 1999 and 61.2% in 2009, prevalence ratio (PR) of 1.13 (95% confidence interval 1.10; 1.16), adjusted for age and smoking.Conclusion:Over the 11-year period from 1999 to 2009, we found a modest increase in overall use of drugs by primiparous women in Denmark. This increase was not, however, explained by an increasing proportion of older first-time mothers. We noted changes in patterns of use of anti-infective drugs and antidepressants.

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“…28,70 However, aminoglycosides have potential risks of ototoxicity and nephrotoxicity in both the mother and the fetus. 27,28,71,72 Gentamycin is the preferred aminoglycoside in obstetrics, if needed, because of its comparatively superior safety profile and low cost. 36 Despite potential risks, no teratogenicity or neonatal ototoxicity or nephrotoxicity has been reported after administration of gentamycin in pregnancy, and gentamycin is widely used.…”

Section: Aminoglycosidesmentioning

confidence: 99%

Urinary Tract Infection and Bacteriuria in Pregnancy

Glaser

Schaeffer

2015

Urologic Clinics of North America

143

115

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Antibiotics in pregnancy: analysis of potential risks and determinants in a large German statutory sickness fund population

Abstract: About 20% of pregnant women received antibiotics, and 1.3% received a harmful drug. To minimise the risks, detailed guidelines are needed for the antibiotic treatment during pregnancy.

Cited by 53 publications

References 27 publications

Drug use during pregnancy in Sweden – assessed by the Prescribed Drug Register and the Medical Birth Register

Drug use during pregnancy in Sweden – assessed by the Prescribed Drug Register and the Medical Birth Register

Use of prescribed drugs among primiparous women: an 11-year population-based study in Denmark

Urinary Tract Infection and Bacteriuria in Pregnancy

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Antibiotics in pregnancy: analysis of potential risks and determinants in a large German statutory sickness fund population

Abstract: About 20% of pregnant women received antibiotics, and 1.3% received a harmful drug. To minimise the risks, detailed guidelines are needed for the antibiotic treatment during pregnancy.

Cited by 53 publications

References 27 publications

Drug use during pregnancy in Sweden &ndash; assessed by the Prescribed Drug Register and the Medical Birth Register

Drug use during pregnancy in Sweden &ndash; assessed by the Prescribed Drug Register and the Medical Birth Register

Use of prescribed drugs among primiparous women: an 11-year population-based study in Denmark

Urinary Tract Infection and Bacteriuria in Pregnancy

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Product

Resources

About

Drug use during pregnancy in Sweden – assessed by the Prescribed Drug Register and the Medical Birth Register

Drug use during pregnancy in Sweden – assessed by the Prescribed Drug Register and the Medical Birth Register