Antibiotics in penetrating abdominal trauma: Comparison of ticarcillin plus clavulanic acid with gentamicin plus clindamycin

Fabian, Timothy C.; Boldreghini, Sandra J.

doi:10.1016/0002-9343(85)90150-0

Cited by 25 publications

(3 citation statements)

References 10 publications

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“…The least expensive, most commonly available agents meeting these criteria are second‐generation cephalosporins (e.g., cefoxitin), which have been shown to be effective in a number of studies [77, 78, 79, 80, 81, 82, 83, 84]. Other appropriate choices include a β ‐lactam penicillin [85, 86, 87, 88] or dual therapy with an aminoglycoside or aztreonam and a specific anaerobic agent such as clindamycin or metronidazole [80, 83, 87, 88, 89, 90, 91, 92, 93, 94]. Use of newer broad‐ spectrum agents such as imipenem cilastin or “triple” antibiotics is not necessary for coverage of normal colon flora, nor is the use of these agents likely to be cost‐effective.…”

Section: Perioperative Antibioticsmentioning

confidence: 99%

Current Management of Colon Trauma

Maxwell

Fabian

2003

World j. surg.

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This article offers a comprehensive review of colon trauma from World War I to the present. The process of evidence-based medicine was used to analyze the data from the past 25 years and define standards of care in the field. Where data are less compelling, recommendations and suggestions are provided for future research. Topics highlighted include destructive and nondestructive colon injuries, rectal injuries, on-table colonic lavage, colonic bypass tubes, risk factors, perioperative antibiotics, and colostomy closure.

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Section: Perioperative Antibioticsmentioning

confidence: 99%

Current Management of Colon Trauma

Maxwell

Fabian

2003

World j. surg.

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“…Antibiotic prophylaxis should be given in penetrating trauma, but it should not last more than 24 hours in the absence of hollow viscus injuries; broad-spectrum antibiotics with aerobic and anaerobic bacteria coverage should be preferred, while aminoglycosides should be avoided whenever possible. In the case of hemorrhagic shock and associated acute kidney injury, the dose of antibiotics should be adjusted 66–95 . Hollow viscus injury with contamination should be considered an indication for antibiotic therapy rather than AP.…”

Section: Definitionsmentioning

confidence: 99%

Antibiotic prophylaxis in trauma: GAIS, SIS-E, WSIS, AAST, WSES guidelines

Coccolini,

Sartelli,

Sawyer

et al. 2023

J Trauma Acute Care Surg

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Trauma is a complex disease, and the use of antibiotic prophylaxis (AP) in trauma patients is common practice. However, considering the increasing rates of antibiotic resistance, AP use should be questioned and limited only to specific cases. Antibiotic stewardship is of paramount importance in fighting resistance spread. Definitive rules or precise indications about antibiotic prophylaxis in trauma remain unclear. The present manuscript describes the indications of antibiotic prophylaxis in traumatic lesions to the head, brain, torso, maxillo-facial, extremities, skin, and soft tissues endorsed by the Global Alliance for Infection in Surgery (GAIS), Surgical Infection Society Europe (SIS-E), World Surgical Infection Society (WSIS), American Association for the Surgery of Trauma (AAST), World Society of Emergency Surgery (WSES).

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“…5 2 5 3 Short duration ticarcillin/potassium clavulanate "prophylactic" therapy of penetrating abdominal injury resulted in a low infection rate equivalent to that seen with clindamycin plus gentamicin. 54…”

Section: Other Infectious Diseasesmentioning

confidence: 99%

Beta-Lactamase Inhibitors: Another Approach to Overcoming Antimicrobial Resistance

Parker

Eggleston

1987

Infect. Control

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Resistance of most clinical pathogens to beta-lactam antimicrobial agents is currently primarily mediated by the microorganisms' ability to product beta-lactamases. There are a variety of beta-lactamases which are primarily differentiated by whether they are plasmid- or chromosome-mediated and by their substrate and inhibition profiles. The most common group of beta-lactamases produced by clinical isolates are the plasmid-mediated TEM enzymes (Richmond-Sykes type III a) which exist in many Enterobacteriaceae, Hemophilus influenzae, and Neisseria species. Development of new beta-lactam antimicrobial agents during the past decades has resulted in a number of drugs with increased, albeit not total, resistance to beta-lactamases. Another approach has been the development of beta-lactamase inhibitors that can be used with a beta-lactam drug to overcome the resistance created by the beta-lactamase.

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Antibiotics in penetrating abdominal trauma: Comparison of ticarcillin plus clavulanic acid with gentamicin plus clindamycin

Cited by 25 publications

References 10 publications

Current Management of Colon Trauma

Current Management of Colon Trauma

Antibiotic prophylaxis in trauma: GAIS, SIS-E, WSIS, AAST, WSES guidelines

Beta-Lactamase Inhibitors: Another Approach to Overcoming Antimicrobial Resistance

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