Antibiotics in Chronic Suppurative Otitis Media: A Bacteriologic Study

Indudharan, R; Haq, Jalaluddin Ashraful; Aiyar, S

doi:10.1177/000348949910800504

Cited by 59 publications

(45 citation statements)

References 21 publications

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“…Results of the present study showed P. aeruginosa and S. aureus as the most common isolates from active CSOM infections. This is in tandem with the observations made by many other authors [1,10,11,12]. Coagulase negative Staphyloccoccus spp.…”

Section: Discussionsupporting

confidence: 90%

Chronic Suppurative Otitis Media: Optimizing Initial Antibiotic Therapy in a Tertiary Care Setup

Vishwanath

Mukhopadhyay

Prakash

et al. 2011

Indian J Otolaryngol Head Neck Surg

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A prospective study was done to determine the clinico-microbiological profile and the antibiogram of patients with chronic suppurative otitis media. Ninety-four patients presenting with tympanic perforation and ear discharge of more than 3 months were studied. Middle ear swabs obtained aseptically were processed for culture and the isolates identified by standard procedures. Antimicrobial susceptibility testing of the aerobic bacterial isolates was performed by disc diffusion method according to clinical laboratory standards institute guidelines. Patients in the age group of 21-30 years were more commonly affected (22.3%). Male:Female ratio was 2:1.4. Of the 94 patients, 64 (68.1%) had tubo-tympanic disease and rest 30 (31.9%) presented with attico-antral disease. Monomicrobial flora was seen in 55 (58.5%) samples, 28 (29.8%) yielded polymicrobial growth and 11 (11.7%) samples were sterile. A total of 115 microbial isolates (86 aerobic bacteria, 18 anaerobic bacteria and 11 fungi) were obtained. Pseudomonas aeruginosa (32.2%) was the most common isolate followed by Staphylococcus aureus (17.4%). Amongst anaerobes, gram positive cocci were more commonly isolated (38.9%). Aspergillus spp. (72.7%) were the most common fungus isolated. Most of the Pseudomonas aeruginosa isolates (25, 67.6%) were susceptible to all the antibiotics. Among the commonly used topical agents in the treatment of CSOM, tobramycin was the most effective (83.8%), followed by gentamicin (78.1%), ciprofloxacin (75.6%) and neomycin (3.5%). Periodic monitoring of the microbiological profile along with their sensitivity pattern is essential for formulating an effective antibiotic policy for CSOM.

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Section: Discussionsupporting

confidence: 90%

Chronic Suppurative Otitis Media: Optimizing Initial Antibiotic Therapy in a Tertiary Care Setup

Vishwanath

Mukhopadhyay

Prakash

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…Observations by Indudharan et al [18] are similar to Yuen et al [17] who reported the presence of P. aeruginosa (27.2%) and S. aureus (23.6%) in their study population. Pseudomonas showed total sensitivity (100%) to ciprofloxacin; significant sensitivity (95.4%) was shown toward polymyxin B.…”

Section: Discussionsupporting

confidence: 84%

Middle Ear and Nasopharyngeal Bacterial Flora and Their Sensitivity in Active Stage of Mucosal Disease Otitis Media: A Comparison

Vuppala¹,

Burugula²,

Balakrishnan³

2016

Asian J Pharm Clin Res

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Objective: Identifying the role of nasopharyngeal bacteria in recurrent middle ear (ME) infection helps in developing an effective treatment strategy. We aimed to compare bacterial flora of ME with nasopharynx (NP) and their sensitivity patterns in active stage of mucosal disease -otitis media (CSOM).Methods: Ear and nasopharyngeal swabs from patients with active ear discharge for >3 months were processed for culture and sensitivity, the organisms were identified using Gram-stain.Results: Twenty patients between 10 and 65 years and male:female ratio of 13:7 were enrolled. 9 had symptoms since childhood. 10 patients complained unilateral ear discharge; five each had discharge from the left and right ear. 11 patients had nasal symptoms; nose block due to obstruction (9), nasal discharge (8), and both symptoms were seen in eight patients. 14 patients (70.0%) had deviated nasal septum and 8 (40.0%) had discharge in the NP. Of 20 ear swabs, 19 grew bacteria; 1 was sterile (5.0%). 13 (65%) nasopharyngeal swabs grew bacteria, 7 were sterile. Culture yielded aerobic bacteria. Staphylococcus aureus was the most common bacterium (9/20, 45.0%) followed by Pseudomonas (7/20, 35.0%) isolated from the ear. The most common nasopharyngeal isolate was S. aureus (9=45%). 10 patients had common ME and nasopharyngeal flora. Organisms were sensitive to amoxicillin+clavulanic acid, fluoroquinolones. Sensitivity was observed to polymyxin, trimethoprim, and sulfamethoxazole also. Conclusion:Common ME and nasopharyngeal flora with same antibiotic sensitivity pattern suggest nasopharyngeal etiology. Nasopharyngeal flora may have a role in recurrent ME infections in mucosal disease -otitis media.

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“…Similarly, Poorey & lyer 15 isolated Pseudomonas in 35.2% ears. Pseudomonas was also isolated as the predominant organism by Maji PK et al 16 (63.8%), Kumar S et al 17 (45.9%) and lndudharan R et al 18 (27.2%).…”

Section: Resultsmentioning

confidence: 92%

Prevalence and Antimicrobial Sensitivity Pattern of Pseudomonas Aeruginosa From Chronic Suppurative Otitis Media (Csom) Cases in a Tertiary Care Hospital of Bihar

Kumar¹,

Kumari²,

Shailesh³

et al. 2017

jemds

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BACKGROUNDAmong the bacteria causing CSOM, Pseudomonas aeruginosa has been particularly blamed for the deep-seated and progressive destruction of middle ear and mastoid structures through its toxins and enzymes. Objective-To study the prevalence and antimicrobial sensitivity pattern of P. aeruginosa in CSOM cases. MATERIALS AND METHODSThis study was conducted over a time period of one and a half years. Pseudomonas aeruginosa isolates from ear discharge specimens of clinically diagnosed cases of CSOM were identified and confirmed by standard methods. Antimicrobial sensitivity testing of the isolates was done by Kirby-Bauer disc diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines. RESULTSAll the 42 (100%) isolates were sensitive to fluoroquinolone group of antibiotics whereas cephalosporin was the second most effective group, which showed 97% sensitivity. It was followed by Aminoglycosides (60%), Ampicillin (23%), Macrolides (22%) and Amoxicillin/clavulanic acid (15%). CONCLUSIONOverall the most sensitive antibiotic groups were fluoroquinolones and cephalosporins and least effective were penicillins and macrolides. Antimicrobial stewardship should be practised to prevent MDR cases. The infection control measure should be followed properly.

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Antibiotics in Chronic Suppurative Otitis Media: A Bacteriologic Study

Cited by 59 publications

References 21 publications

Chronic Suppurative Otitis Media: Optimizing Initial Antibiotic Therapy in a Tertiary Care Setup

Chronic Suppurative Otitis Media: Optimizing Initial Antibiotic Therapy in a Tertiary Care Setup

Middle Ear and Nasopharyngeal Bacterial Flora and Their Sensitivity in Active Stage of Mucosal Disease Otitis Media: A Comparison

Prevalence and Antimicrobial Sensitivity Pattern of Pseudomonas Aeruginosa From Chronic Suppurative Otitis Media (Csom) Cases in a Tertiary Care Hospital of Bihar

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