Antibiotics From Woods of Brazilian Origin

KORZYBSKI, TADEUSZ; KOWSZYK-GINDIFER, ZUZANNA; KURYŁOWICZ, WŁODZIMIERZ

doi:10.1016/b978-1-4831-9801-9.50268-3

Cited by 9 publications

(10 citation statements)

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“…They are regarded as safe biological agents and their potential is considered high [ 4 ]. As they are bacterial antagonists, the assumption is that their antagonistic effects are due mainly to production of antifungal antibiotics [ 5 ], which appear to play a major role in biological control of plant pathogens [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several abiotic factors, such as pH and temperature, have been identified as having an influence on antibiotic production from bacteria [ 8 ]. Antifungal peptides produced by Bacillus species include mycobacillins [ 9 ], surfactins [ 10 ], mycosubtilins [ 11 ], and fungistatins [ 5 ]. It can produce a wide range of other metabolites, including chitinases and other cell wall-degrading enzymes [ 12 , 13 ], volatiles [ 13 ], and compounds that elicit plant resistance mechanisms [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Isolation and Identification of Antifungal Compounds from Bacillus subtilis C9 Inhibiting the Growth of Plant Pathogenic Fungi

et al. 2012

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Antagonistic microorganisms against Rhizoctonia solani were isolated and their antifungal activities were investigated. Two hundred sixteen bacterial isolates were isolated from various soil samples and 19 isolates were found to antagonize the selected plant pathogenic fungi with varying degrees. Among them, isolate C9 was selected as an antagonistic microorganism with potential for use in further studies. Treatment with the selected isolate C9 resulted in significantly reduced incidence of stem-segment colonization by R. solani AG2-2(IV) in Zoysia grass and enhanced growth of grass. Through its biochemical, physiological, and 16S rDNA characteristics, the selected bacterium was identified as Bacillus subtilis subsp. subtilis. Mannitol (1%) and soytone (1%) were found to be the best carbon and nitrogen sources, respectively, for use in antibiotic production. An antibiotic compound, designated as DG4, was separated and purified from ethyl acetate extract of the culture broth of isolate C9. On the basis of spectral data, including proton nuclear magneric resonance (1H NMR), carbon nuclear magneric resonance (13C NMR), and mass analyses, its chemical structure was established as a stereoisomer of acetylbutanediol. Application of the ethyl acetate extract of isolate C9 to several plant pathogens resulted in dose-dependent inhibition. Treatment with the purified compound (an isomer of acetylbuanediol) resulted in significantly inhibited growth of tested pathogens. The cell free culture supernatant of isolate C9 showed a chitinase effect on chitin medium. Results from the present study demonstrated the significant potential of the purified compound from isolate C9 for use as a biocontrol agent as well as a plant growth promoter with the ability to trigger induced systemic resistance of plants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Antifungal Compounds from Bacillus subtilis C9 Inhibiting the Growth of Plant Pathogenic Fungi

et al. 2012

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“…1A) is produced by different streptomycete species, usually as the main component of a mixture. At least five components have been described, differing in minor modifications of the sugar moieties (Korzybski et al ., 1978). Chromomycin A 2 differs from chromomycin A 3 in the acyl residue bound to the 4hydroxyl group of the 4-O-acetyl-L -chromose B (sugar E) of the trisaccharide chain ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A₃ by Streptomyces griseus ssp. griseus

Menéndez

Nur‐e‐Alam

Braña

et al. 2004

Molecular Microbiology

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Chromomycin A3 is a member of the aureolic acid group family of antitumour drugs. Three tailoring modification steps occur during its biosynthesis affecting the sugar moieties: two O-acetylations and one O-methylation. The 4-O-methylation in the 4-O-methyl-D-oliose moiety of the disaccharide chain is catalysed by the cmmMIII gene product. Inactivation of this gene generated a chromomycin-non-producing mutant that accumulated three unmethylated derivatives containing all sugars but differing in the acylation pattern. Two of these compounds were shown to be substrates of the methyltransferase as determined by their bioconversion into chromomycin A2 and A3 after feeding these compounds to a Streptomyces albus strain expressing the cmmMIII gene. The same single membrane-bound enzyme, encoded by the cmmA gene, is responsible for both acetyl transfer reactions, which convert a relatively inactive compound into the bioactive chromomycin A3. Insertional inactivation of this gene resulted in a mutant accumulating a dideacetylated chromomycin A3 derivative. This compound, lacking both acetyl groups, was converted in a two-step reaction via the 4E-monoacetylated intermediate into chromomycin A3 when fed to cultures of S. albus expressing the cmmA gene. This acetylation step would occur as the last step in chromomycin biosynthesis, being a very important event for self-protection of the producing organism. It would convert a molecule with low biological activity into an active one, in a reaction catalysed by an enzyme that is predicted to be located in the cell membrane.

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“…Antibiotics are the bioactive compounds with low molecular weight (MW 3000) produced by different organisms i.e., bacteria, fungi, algae, lichens, green plants, etc. via fermentation [ 75 , 76 ]. Antibiotics are generally defensive in function and often toxic to other species (e.g., penicillin, originally produced by bread mold, is toxic to numerous human pathogens).…”

Section: Introductionmentioning

confidence: 99%

Fermentation: A Boon for Production of Bioactive Compounds by Processing of Food Industries Wastes (By-Products)

et al. 2018

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A large number of by-products or wastes are produced worldwide through various food industries. These wastes cause a serious disposable problem with the environment. So, now a day’s different approaches are used for alternative use of these wastes because these by-products are an excellent source of various bioactive components such as polyphenols, flavonoids, caffeine, carotenoids, creatine, and polysaccharides etc. which are beneficial for human health. Furthermore, the composition of these wastes depends on the source or type of waste. Approximately half of the waste is lignocellulosic in nature produced from food processing industries. The dissimilar types of waste produced by food industries can be fortified by various processes. Fermentation is one of the oldest approaches and there are three types of fermentation processes that are carried out such as solid state, submerged and liquid fermentation used for product transformation into value added products through microorganisms. Selections of the fermentation process are product specific. Moreover, various studies were performed to obtain or fortified different bioactive compounds that are present in food industries by-products or wastes. Therefore, the current review article discussed various sources, composition and nutritive value (especially bioactive compounds) of these wastes and their management or augmentation of value-added products through fermentation.

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Antibiotics From Woods of Brazilian Origin

Cited by 9 publications

References 1 publication

Isolation and Identification of Antifungal Compounds from Bacillus subtilis C9 Inhibiting the Growth of Plant Pathogenic Fungi

Isolation and Identification of Antifungal Compounds from Bacillus subtilis C9 Inhibiting the Growth of Plant Pathogenic Fungi

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A₃ by Streptomyces griseus ssp. griseus

Fermentation: A Boon for Production of Bioactive Compounds by Processing of Food Industries Wastes (By-Products)

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Antibiotics From Woods of Brazilian Origin

Cited by 9 publications

References 1 publication

Isolation and Identification of Antifungal Compounds from Bacillus subtilis C9 Inhibiting the Growth of Plant Pathogenic Fungi

Isolation and Identification of Antifungal Compounds from Bacillus subtilis C9 Inhibiting the Growth of Plant Pathogenic Fungi

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A3 by Streptomyces griseus ssp. griseus

Fermentation: A Boon for Production of Bioactive Compounds by Processing of Food Industries Wastes (By-Products)

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Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A₃ by Streptomyces griseus ssp. griseus