Antibiotics for treating human brucellosis

Abstract

Doxycycline (six weeks) plus streptomycin (two or three weeks) regimen is more effective regimen than doxycycline plus rifampicin (six weeks) regimen. Since it needs daily intramuscular (IM) injection, access to care and cost are important factors in deciding between two choices. Quinolone plus rifampicin (six weeks) regimen is slightly better tolerated than doxycycline plus rifampicin, and low quality evidence did not show any difference in overall effectiveness.

Efficacy and safety of therapeutic strategies for human brucellosis: A systematic review and network meta-analysis

“…This review updates the synthesis of evidence available for therapeutic interventions for treating human brucellosis with the differential of using a more comprehensive approach based on indirect comparisons made possible by network meta-analyses. The results are in line with those of previous studies, confirming the superiority of the doxycycline + streptomycin regimen for six weeks compared to doxycycline + rifampicin [12,15]. Therapeutic regimens based on binary combinations, including doxycycline, predominate in the literature.…”

“…Karami et al (2020) [55], evaluating the same intervention in 2020 in eight and 12 weeks, also did not identify the superiority of the longer treatment in relation of recurrence. In the findings of this review and those published previously [12,15], the superiority of aminoglycoside regimens is well established. However, the use of triple therapy remains a factor under evaluation, either by proving the superiority or even indicating the appropriate treatment time.…”

Efficacy and safety of therapeutic strategies for human brucellosis: A systematic review and network meta-analysis

“…This review updates the synthesis of evidence available for therapeutic interventions for treating human brucellosis with the differential of using a more comprehensive approach based on indirect comparisons made possible by network meta-analyses. The results are in line with those of previous studies, confirming the superiority of the doxycycline + streptomycin regimen for six weeks compared to doxycycline + rifampicin [12,15]. Therapeutic regimens based on binary combinations, including doxycycline, predominate in the literature.…”

“…Karami et al (2020) [55], evaluating the same intervention in 2020 in eight and 12 weeks, also did not identify the superiority of the longer treatment in relation of recurrence. In the findings of this review and those published previously [12,15], the superiority of aminoglycoside regimens is well established. However, the use of triple therapy remains a factor under evaluation, either by proving the superiority or even indicating the appropriate treatment time.…”

Risk Factor Analysis of Brucellosis in Hulunbuir, China, Using the Propensity Score Matching Method

“…From the perspective of ethnicity and consistent with previous studies, the Mongolian population had the lowest infection rates (25)(26)(27). The highest infection rates of other ethnic minorities can be explained by living habits and breeding methods (28,29). Amongst the survey population, herders and veterinarians were occupational groups with the highest infection rates.…”

Endogenous Brucella endophthalmitis: A case report

“…Current recommended treatment regimen of Brucellosis involves the use of two or more antibiotics including doxycycline, streptomycin, rifampin, gentamicin, or trimethoprim-sulfamethoxazole in combination to avoid relapses 8 . In the present case report, initially the patient had received a combination of doxycycline and rifampicin as suggested in the literature.…”

Efficacy and safety of therapeutic strategies for human brucellosis: A systematic review and network meta-analysis

“…This review updates the synthesis of evidence available for therapeutic interventions for treating human brucellosis with the differential of using a more comprehensive approach based on indirect comparisons made possible by network meta-analyses. The results are in line with those of previous studies, confirming the superiority of the doxycycline + streptomycin regimen for six weeks compared to doxycycline + rifampicin [12,15]. Therapeutic regimens based on binary combinations, including doxycycline, predominate in the literature.…”

“…Karami et al (2020) [55], evaluating the same intervention in 2020 in eight and 12 weeks, also did not identify the superiority of the longer treatment in relation of recurrence. In the findings of this review and those published previously [12,15], the superiority of aminoglycoside regimens is well established. However, the use of triple therapy remains a factor under evaluation, either by proving the superiority or even indicating the appropriate treatment time.…”

Risk Factor Analysis of Brucellosis in Hulunbuir, China, Using the Propensity Score Matching Method

“…From the perspective of ethnicity and consistent with previous studies, the Mongolian population had the lowest infection rates (25)(26)(27). The highest infection rates of other ethnic minorities can be explained by living habits and breeding methods (28,29). Amongst the survey population, herders and veterinarians were occupational groups with the highest infection rates.…”

Endogenous Brucella endophthalmitis: A case report

“…Current recommended treatment regimen of Brucellosis involves the use of two or more antibiotics including doxycycline, streptomycin, rifampin, gentamicin, or trimethoprim-sulfamethoxazole in combination to avoid relapses 8 . In the present case report, initially the patient had received a combination of doxycycline and rifampicin as suggested in the literature.…”

Efficacy and safety of therapeutic strategies for human brucellosis: A systematic review and network meta-analysis

“…This review updates the synthesis of evidence available for therapeutic interventions for treating human brucellosis with the differential of using a more comprehensive approach based on indirect comparisons made possible by network meta-analyses. The results are in line with those of previous studies, confirming the superiority of the doxycycline + streptomycin regimen for six weeks compared to doxycycline + rifampicin [12,15]. Therapeutic regimens based on binary combinations, including doxycycline, predominate in the literature.…”

“…Karami et al (2020) [55], evaluating the same intervention in 2020 in eight and 12 weeks, also did not identify the superiority of the longer treatment in relation of recurrence. In the findings of this review and those published previously [12,15], the superiority of aminoglycoside regimens is well established. However, the use of triple therapy remains a factor under evaluation, either by proving the superiority or even indicating the appropriate treatment time.…”

Risk Factor Analysis of Brucellosis in Hulunbuir, China, Using the Propensity Score Matching Method

“…From the perspective of ethnicity and consistent with previous studies, the Mongolian population had the lowest infection rates (25)(26)(27). The highest infection rates of other ethnic minorities can be explained by living habits and breeding methods (28,29). Amongst the survey population, herders and veterinarians were occupational groups with the highest infection rates.…”

Endogenous Brucella endophthalmitis: A case report

“…Current recommended treatment regimen of Brucellosis involves the use of two or more antibiotics including doxycycline, streptomycin, rifampin, gentamicin, or trimethoprim-sulfamethoxazole in combination to avoid relapses 8 . In the present case report, initially the patient had received a combination of doxycycline and rifampicin as suggested in the literature.…”