Antibiotics for treating chronic osteomyelitis in adults

Abstract

Limited evidence suggests that the method of antibiotic administration (oral versus parenteral) does not affect the rate of disease remission if the bacteria are sensitive to the antibiotic used. However, this and the lack of statistically significant differences in adverse effects need confirmation. No or insufficient evidence exists for other aspects of antibiotic therapy for chronic osteomyelitis.

Development of New Localized Drug Delivery System Based on Ceftriaxone-Sulbactam Composite Drug Impregnated Porous Hydroxyapatite: A Systematic Approach for In Vitro and In Vivo Animal Trial

“…The band assignments of FTIR spectrum obtained at different wave numbers are summarized in Table II. It was evident that the respective functional groups for PO 4 3-and OHcorresponding to HAp crystals (34,35) were present in Figs. 2a-c.…”

“…2c). This could be interpreted as a release of carbonate from PO 4 3-positions in the apatite structure.…”

“…As dried powder was composed of amorphous or defective calcium phosphate which is usually expressed by the formula Ca 10-x (PO 4 ) 6-x (HPO 4 ) x (OH) 2-x (44). In fact, as-dried powder showed presence of this HPO 4 2-in minute quantity and retained at 800°C samples. This indicates that structural reorientation was occurring with the manifestation of thermal energy.…”

“…ceramic and drug), and the EDAX at the interface showed mixture of above elements. One of the reasons for absence of interfacial gap between the drug and pore surface was due to electrostatic attraction between the functional groups of CFS and Ca 2+ and PO 4 3-. Further, high adhesion strength and subsequent cracks on the drug surface were due to higher surface potential on HAp surface, which contributed such phenomenon.…”

“…As the condition is frequently associated with poor vascular perfusion accompanied by infection of surrounding tissue (2), surgical debridement and prolonged administration (about 4-6 weeks) of antibacterial agents constitute the mainstay therapy for orthopaedic infections (3). Despite the availability of a myriad of antibiotics and marked advances in surgical treatment, the long-term recurrence rate remains alarming at a rate of 20% to 30% (4). Absence of antibiotics labelled exclusively for osteomyelitic conditions leave the choice of therapy to the preferences and experience of the attending physicians (5).…”