Antibiotics for childhood urinary tract infection: can we be smarter?

Costelloe, Céire

doi:10.3399/bjgp13x665099

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…There is a suggestion that nitrofurantoin or first-generation cephalosporins be considered as initial therapy as they exhibit the best resistance profile. 25 , 37 …”

Section: Place In Therapymentioning

confidence: 99%

Clinical Options for the Treatment of Urinary Tract Infections in Children

Ramlakhan

Singh

Stone

et al. 2014

Clin Med Insights Pediatr

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Urinary Tract Infections (UTI) are a common cause of childhood febrile illness with 7% of girls and 2% of boys having a symptomatic culture positive UTI by the age of six years. Although there are conflicting views on the long term sequelae of UTI, as well as the place of prophylaxis, the universal aims of treatment of childhood UTI remain those of symptom alleviation, prevention of systemic infection and short and longer term complications. There is good evidence of historical and emerging resistance patterns, therefore rationalisation of prescription patterns by knowledge of sensitivities coupled with re-examination of empirical antibiotic choices is clearly important. Local formularies should reflect geographical resistance patterns along with best evidence on the duration and choice of antibiotic in order to maximize therapeutic effect, while minimizing the development of resistant strains.

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“…There is a suggestion that nitrofurantoin or first-generation cephalosporins be considered as initial therapy as they exhibit the best resistance profile. 25 , 37 …”

Section: Place In Therapymentioning

confidence: 99%

Clinical Options for the Treatment of Urinary Tract Infections in Children

Ramlakhan

Singh

Stone

et al. 2014

Clin Med Insights Pediatr

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“…However, greater accessibility resulted in irrational and excessive use leading to antibiotic resistance (ABR). [ 3 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude, and practices of health-care providers toward antibiotic prescribing, antibiotic resistance, and multidrug-resistant tuberculosis

Malhotra

Kumar

Juyal

et al. 2021

Perspectives in Clinical Research

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Introduction: Antibiotic resistance (ABR) is a growing public health problem and is a subject of international concern. It poses a serious threat to health and health-care systems in both developed and developing countries. The problem is more confounding with tuberculosis (TB), and drug resistance in TB has threatened the progress made in TB care and control worldwide. The aim of this study was to understand the knowledge, attitude, and practices of health-care providers (HCPs) toward antibiotics, antibiotic prescribing, ABR, and multidrug-resistant TB (MDR-TB). Materials and Methods: A total of 125 participants were included in this cross-sectional, questionnaire-based survey conducted in tertiary care teaching hospitals of the Delhi-NCR region. A five-point Likert scale, whose responses ranged from “strongly agree” to “do not know,” was used to record the responses from participants. Results: Among the 125 HCPs who participated in the survey, the response rate was 100%. Around 94.4% of the respondents agreed that ABR is an important and a serious public health issue. More than 80% of the respondents strongly agreed that over-the-counter sale and/or dispensing antibiotics without prescription should be controlled. About 86.4% of the participants agreed that MDR-TB is a growing problem and 59.2% strongly agreed that indiscriminate use of anti-TB drugs could be a major causative factor. Almost 85.6% of the participants agreed that a proper diagnosis should be ensured before treating the TB cases. Conclusions: HCPs had a good knowledge of antibiotics and the association of its misuse or overuse with increasing ABR. Educational and persuasive measures are certainly needed, but the use of restrictive and organizational measures appears mandatory if the misuse of antibiotics is to be decreased in the near future. A stringent assessment of the impact of implemented measures seems essential to better guide antibiotic stewardship in our country.

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“…Countries such as France, which are rated medium in terms of primary care, are among the top performers in relation to health outcomes that can be attributed to health care. 7 So where are we then? There is widespread variation in the way primary care is conceptualised and implemented, and some uncertainties about the costs and effectiveness of primary care.…”

Section: Challenges For Primary Carementioning

confidence: 99%

“…4 Despite good evidence that antibiotics do not reduce the duration or severity of LRTI, 5 they continue to be widely prescribed 3 promoting bacterial resistance to antibiotics. 6 Between 2002 and 2010, the total number of antibiotics dispensed per 1000 population in England increased by an alarming 25%, 7 a statistic that cannot be explained by increasing primary care presentations: consultations for upper and lower RTIs fell by 19% in the same period. 8 So why is our antibiotic prescribing increasing?…”

Section: Introductionmentioning

confidence: 99%