Antibiotics for adults with acute cholecystitis or acute cholangitis or both

Markotić, Filipa; Poropat, Goran; Fox, Adrian; Nikolova, Dimitrinka; Vukojević, Katarina; Jakobsen, Janus Christian; Gluud, Christian

doi:10.1002/14651858.cd013646

Cited by 3 publications

(2 citation statements)

References 105 publications

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“…We defined a serious adverse event according to the International Conference on Harmonization (ICH) Guidelines for GCP, as "any untoward medical occurrence that results in death, is lifethreatening, requires inpatient hospitalisation or prolongation of existing hospitalisation, results in persistent or significant disability or incapacity, or is a congenital anomaly or birth defect" (ICH-GCP 2016). This reflects the description used in another Cochrane review protocol (Markotic 2020). We intended to specifically report on hepatobiliary conditions including cholecystitis, pancreatitis, cholangitis, obstructive jaundice, and gallbladder cancer.…”

Section: Primary Outcomesmentioning

confidence: 99%

Modified dietary fat intake for treatment of gallstone disease in people of any age

Madden,

Smeeton,

Culkin

et al. 2024

Cochrane Database of Systematic Reviews

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Section: Primary Outcomesmentioning

confidence: 99%

Modified dietary fat intake for treatment of gallstone disease in people of any age

Madden,

Smeeton,

Culkin

et al. 2024

Cochrane Database of Systematic Reviews

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“… 1 Gallstones affect approximately 6% of men and 9% of women in the United States. 2 According to estimates, approximately $62 billion is allocated annually in the United States for the prevention and treatment of cholelithiasis. 3 Around 10% of people with asymptomatic gallstones will experience symptoms or need treatment within five years.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Mediates the Relationship Between Atherogenic Index of Plasma and Gallstones: A Population-Based Cross-Sectional Study

Du,

Wang,

Song

et al. 2024

DMSO

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Purpose Previous studies have shown a correlation between diabetes mellitus and gallstone formation. The atherogenic index of plasma (AIP) is associated with many metabolic diseases. However, insufficient evidence still exists to elucidate the association between AIP and gallstones. The primary objective of this study was to investigate the correlation between AIP and gallstones in US adults, and the secondary objective was to analyze whether diabetes plays a mediating role in the association. Patients and Methods Using data from the National Health and Nutrition Survey (NHANES) conducted between 2017 and March 2020, this study investigated the association between AIP and gallstone incidence in US adults. A variety of statistical methods were used to analyze the data in this study, including multivariate logistic regression, subgroup analyses, restricted cubic spline curves (RCS), and mediation effects analysis. In addition, two-stage linear regression was used to detect possible threshold and saturation effects. Results A total of 6952 subjects were enrolled in the trial, of which 748 patients were diagnosed with gallstones. A significant positive association between AIP and gallstones was observed by fully adjusted multivariate logistic regression analysis, with an odds ratio (OR) of 1.45 and a 95% confidence interval (CI) of (1.09, 1.93). In addition, a non-linear positive association and saturation effect between AIP and gallstones were found, with an inflection point of 0.2246. Mediation analysis showed that diabetes had a mediating effect of 16.9% in the association between AIP and gallstones. Conclusion This study suggests that elevated levels of AIP are linked to an augmented vulnerability to gallstone development, with diabetes serving as a mediating factor. These findings present a novel perspective on clinical approaches to prevent and manage gallstones.

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Modified dietary fat intake for treatment of gallstone disease

Madden

Trivedi

Smeeton

et al. 2021

Cochrane Database of Systematic Reviews

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Antibiotics for adults with acute cholecystitis or acute cholangitis or both

Abstract: a Filipa Markotic shares first authorship with Svjetlana Grgic as both have worked together on the review protocol and contributed equally.. b Svjetlana Grgic shares first authorship with Filipa Markotic as both have worked together on the review protocol and contributed equally.

Cited by 3 publications

References 105 publications

Modified dietary fat intake for treatment of gallstone disease in people of any age

Modified dietary fat intake for treatment of gallstone disease in people of any age

Diabetes Mellitus Mediates the Relationship Between Atherogenic Index of Plasma and Gallstones: A Population-Based Cross-Sectional Study

Modified dietary fat intake for treatment of gallstone disease

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