Antibiotics Elution Depth in Bone Cement: Impact of Surface Area and Volume
Yu-Yi Huang,
Yu-Chih Lin,
Chih-Hsiang Chang
et al.
Abstract:Antibiotic-loaded bone cement (ALBC) plays a pivotal role in infection prevention and treatment related to musculoskeletal surgery. The release efficacy of antibiotics from ALBC is closely tied to its surface area, yet little is known about the effective release depth. To investigate the relationship between surface area, volume, and antibiotic elution, spheric ALBC specimens with consistent outer diameters but different internal metal sphere diameters were prepared. Two vancomycin doses were utilized in ALBC … Show more
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