Antibiotics as CECs: An Overview of the Hazards Posed by Antibiotics and Antibiotic Resistance

Scott, Geoffrey I.; Porter, Dwayne E.; Norman, R. Sean; Scott, Cecile Hart; Uyaguari, Miguel; Maruya, Keith A.; Weisberg, Stephen B.; Fulton, Michael H.; Wirth, Edward; Moore, John Robert; Pennington, Paul L.; Schlenk, Daniel; Cobb, George P.; Denslow, Nancy D.

doi:10.3389/fmars.2016.00024

Cited by 36 publications

(16 citation statements)

References 52 publications

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“…Tidal range differences be-tween the SE Atlantic and Gulf Coast may range from 3 to 4-fold, suggesting that tidal dilution may play a role in ob-served Vv levels. Scott (2016) reported similar tidal dilution effects on rates of E. coli antibiotic resistance in comparisons between the Gulf, Mid Atlantic, and SE Atlantic coasts.…”

Section: Discussionmentioning

confidence: 66%

Impact of Climate Change on Vibrio vulnificus Abundance and Exposure Risk

Deeb

Tufford

Scott

et al. 2018

Estuaries and Coasts

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Vibrio species are marine bacteria that occur in estuaries worldwide; many are virulent human pathogens with high levels of antibiotic resistance. The average annual incidence of all Vibrio infections has increased by 41% between 1996 and 2005. V. vulnificus (Vv), a species associated with shellfish and occurring in the US Southeast, has ranges of temperature (16–33 °C) and salinity (5–20 ppt) dependencies for optimal growth. Increased water temperatures caused by atmospheric warming and increased salinity gradients caused by sea level rise raise concerns for the effect of climate change on the geographic range of Vv and the potential for increased exposure risk. This research combined monthly field sampling, laboratory analysis, and modeling to identify the current occurrence of Vv in the Winyah Bay estuary (South Carolina, USA) and assess the possible effects of climate change on future geographic range and exposure risk in the estuary. Vv concentrations ranged from 0 to 58 colony forming units (CFU)/mL, salinities ranged from 0 to 28 ppt, and temperature from 18 to 31 °C. A significant empirical relationship was found between Vv concentration and salinity and temperature that fit well with published optimal ranges for growth for these environmental parameters. These results, when coupled with an existing model of future specific conductance, indicated that sea level rise has a greater impact on exposure risk than temperature increases in the estuary. Risk increased by as much as four times compared to current conditions with the largest temporally widespread increase at the most upriver site where currently there is minimal risk.

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Section: Discussionmentioning

confidence: 66%

Impact of Climate Change on Vibrio vulnificus Abundance and Exposure Risk

Deeb

Tufford

Scott

et al. 2018

Estuaries and Coasts

Self Cite

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“…That may be explained by the different approaches to the research that countries conventionally follow in this field. As a matter of fact, Canadian and US studies usually cover wide-ranging reviews on the hazards posed by AMR [40][41][42] or deal with the genomic and transcriptomic facets of the resistance of bacteria [43,44]. Moreover, the interest in drug-resistant pathogenic microorganisms is widely shared in South America, as proven by several papers published in Brazil [45][46][47].…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Pharmaceuticals in Wastewater Treatment Plants: A Systematic Review on the Substances of Greatest Concern Responsible for the Development of Antimicrobial Resistance

et al. 2021

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In recent years, there is a growing concern about the alarming spread of antimicrobial resistance (AMR) in different environments. Increasingly, many species of bacteria, fungi and viruses are becoming immune to the most commonly used pharmaceuticals. One of the causes of the development of the resistance is the persistence of these drugs, excreted by humans, in municipal and hospital wastewater (WW). Consequently, wastewater treatment plants (WWTPs) are a primary source of antimicrobial resistance genes as novel pollutants. This systematic review sought to examine the relevant literature on pharmaceutical residues (PRs) responsible for AMR in municipal and hospital WW in order to propose a classification of the PRs of greatest concern and provide an updated source for AMR management in WWTPs. Among 546 studies collected from four databases, 18 were included in the present review. The internal and external validity of each study was assessed, and the risk of bias was evaluated on a 20-parameter basis. Results were combined in a narrative synthesis discussing influent and effluent PR concentrations at 88 WWTPs, seasonal variations, differences between hospital and municipal WW, environmental risk assessment values of antimicrobial substances and treatment facilities removal efficiencies. Among the 45 PRs responsible for AMR evaluated in this study, the antibiotics ciprofloxacin, clarithromycin, erythromycin, metronidazole, ofloxacin, sulfamethoxazole and trimethoprim constitute a considerable risk in terms of ubiquitous distribution, worrying concentrations, risk quotient values and resistance to removal treatments. Gaps in knowledge, data and information reported in this review will provide a valuable source for managing AMR in WWTPs.

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“…That may be explained by the different approaches to the research that countries conventionally follow in this field. As a matter of fact, Canadian and US studies usually cover wide-ranging reviews on the hazards posed by AMR [40,41,42] or deal with the genomic and transcriptomic facets of the resistance of bacteria [43,44]. Besides, the interest in drug-resistant pathogenic microorganisms is widely shared in South America, as proven by several papers published in Brazil [45,46,47].…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Pharmaceuticals in Wastewater Treatment Plants: A Systematic Review on the Substances of Greatest Concern Responsible for the Development of Antimicrobial Resistance

Frascaroli

Reid

Hunter

et al. 2021

Preprint

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In recent years, there is a growing concern about the alarming spread of antimicrobial resistance (AMR) in different environments. Increasingly, many species of bacteria, fungi and viruses are becoming immune to the most commonly used pharmaceuticals. One of the causes of the development of the resistance is the persistence of these drugs, excreted by humans, in municipal and hospital wastewater (WW). Consequently, wastewater treatment plants (WWTPs) are a primary source of antimicrobial resistance genes as novel pollutants. This systematic review sought to examine the relevant literature on pharmaceutical residues (PRs) responsible for AMR in municipal and hospital WW in order to propose a classification of the PRs of greatest concern and provide an updated source for AMR management in WWTPs. Among 546 studies collected from four databases, 18 were included in the present review. The internal and external validity of each study was assessed, and the risk of bias was evaluated on a 20-parameter basis. Results were combined in a narrative synthesis discussing influents and effluents PR concentrations at 88 WWTPs, seasonal variations, differences between hospital and municipal WW, environmental risk assessment values of antimicrobial substances and treatment facilities removal efficiencies. Among the 45 PRs responsible for AMR evaluated in this study, the antibiotics ciprofloxacin, clarithromycin, erythromycin, metronidazole, ofloxacin, sulfamethoxazole and trimethoprim constitute a considerable risk in terms of ubiquitous distribution, worrying concentrations, risk quotients values, and resistance to removal treatments. Gaps in knowledge, data and information reported in this review provide a valuable source for managing AMR in WWTPs.

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Antibiotics as CECs: An Overview of the Hazards Posed by Antibiotics and Antibiotic Resistance

Cited by 36 publications

References 52 publications

Impact of Climate Change on Vibrio vulnificus Abundance and Exposure Risk

Impact of Climate Change on Vibrio vulnificus Abundance and Exposure Risk

Pharmaceuticals in Wastewater Treatment Plants: A Systematic Review on the Substances of Greatest Concern Responsible for the Development of Antimicrobial Resistance

Pharmaceuticals in Wastewater Treatment Plants: A Systematic Review on the Substances of Greatest Concern Responsible for the Development of Antimicrobial Resistance

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