ANTIBIOTICS AND DRUGS | Uses in Food Production

Woodward, K.N.

doi:10.1016/b0-12-227055-x/00051-1

Cited by 6 publications

(4 citation statements)

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“…To ensure consumer safety, worldwide regulatory authorities have set MRL's (Maximum Residual Limit) for several veterinary drugs [6,7]. These MRL's, are expected to regulate the maximum permitted levels of the drug residue for each antibiotic which is considered safely acceptable in food of animal origin [8].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Antibiotic Residues and Determination of Antimicrobial Resistance Profiles of Microorganisms Isolated from Bovine Milk in Lebanon

Zeina¹,

Pamela²,

Fawwak³

2013

FNS

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The rapid growth of dairy sectors in the Middle East, particularly in Lebanon, led to extensive use of antibiotics to enhance the health and productivity of animals. Prolonged usage may lead to antibiotic residues in foods of animal origin; hence, the emergence of antimicrobial resistant microorganisms. Accurate data on the antibiotic usage in livestock treatment, antibiotic residues and antimicrobial resistances in raw milk in Lebanon are lacking. This study aimed to investigate the types and usages of antibiotics in cattle, their residual levels and the potential microbial resistances in raw milk samples. A questionnaire-based survey identified Gentamicin and Streptomycin as the most frequently used antibiotics. Selected raw milk samples from main dairy farms were then analyzed in duplicate by quantitative ELISA for the antibiotics residual levels. The mean residual levels of Gentamicin and Streptomycin were 90 and 80 μg/L, respectively; which are below the allowable maximum residue limit of 200 μg/L as set by the FAO/WHO. Staphylococcus aureus, Listeria monocytogenes, E. coli and total aerobic microorganisms isolated from the milk samples were then tested for resistance against Gentamicin and Streptomycin by the disc agar diffusion method. All the S. aureus, E. coli, and L. monocytogenes isolates showed high resistance to Gentamicin. However, 95% of S. aureus, 60% of E. coli and 58% of L. monocytogenes isolates were resistant to Streptomycin. The obtained results provide evidence that antimicrobial resistant strains of the above pathogens have become remarkably widespread in raw milk. This requires better management for antibiotic usages among livestock farmers to control sources of food contamination and reduce the health risks associated with the development of resistant microbial strains.

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Section: Introductionmentioning

confidence: 99%

Quantification of Antibiotic Residues and Determination of Antimicrobial Resistance Profiles of Microorganisms Isolated from Bovine Milk in Lebanon

Zeina¹,

Pamela²,

Fawwak³

2013

FNS

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“…It is required to protect milk quality, avoid entering antibiotics into the food chain, and prevent direct discharge of contaminated wastewater. Health risks analysis posed from residual content of antibiotics in the foods is practically challenging to estimate; maximal residue limits (MRLs) have been enforced and censored by several national and international regulatory organizations [15]. Because milk is among the most-traded and heavily regulated products for quality assurance standards and food safety thus, it would be desirable if the single analytical method is applicable to detect AMG antibiotics with nanomolar level sensitivity [16,17].…”

Section: Introductionmentioning

confidence: 99%

Histidine Functionalized Gold Nanoparticles for Screening Aminoglycosides and Nanomolar Level Detection of Streptomycin in Water, Milk, and Whey

et al. 2021

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Aminoglycoside (AMG) antibiotics are being applied to treat infections caused by Gram-negative bacteria, mainly in livestock, and are prescribed only in severe cases because of their adverse impacts on human health and the environment. Monitoring antibiotic residues in dairy products relies on the accessibility of portable and efficient analytical techniques. Presently, high-throughput screening techniques have been proposed to detect several antimicrobial drugs having identical structural and functional features. The L-histidine functionalized gold nanoparticles (His@AuNPs) do not form a complex with other tested antibiotic classes but show high selectivity for AMG antibiotics. We used ligand-induced aggregation of His@AuNPs as a rapid and sensitive localized surface plasmon resonance (LSPR) assay for AMG antibiotics, producing longitudinal extinction shifts at 660 nm. Herein, we explore the practical application of His@AuNPs to detect streptomycin spiked in water, milk, and whey fraction of milk with nanomolar level sensitivity. The ability of the analytical method to recognize target analytes sensitively and rapidly is of great significance to perform monitoring, thus would certainly reassure widespread use of AMG antibiotics. The biosynthesis of hybrid organic–inorganic metal nanoparticles like His@AuNPs with desired size distribution, stability, and specific host–guest recognition proficiency, would further facilitate applications in various other fields.

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“…In Lebanon, there are no regulations on the limits of veterinary drugs residues in meat. As most Lebanese regulations for contaminants are European-inspired, we chose to follow the European Union's (EU) regulation N o 37/2010 on pharmacologically active substances that fixes the maximum residue limits (MRL) for the total amount of SAs and their metabolism products in edible biological tissues, such as muscle, liver, and kidneys at 100 lg kg À1 (Commission regulation (EU), 2009) (Woodward, 2003).…”

Section: Introductionmentioning

confidence: 99%

Monitoring of twenty-two sulfonamides in edible tissues: Investigation of new metabolites and their potential toxicity

Abdallah¹,

Arnaudguilhem²,

Haifa

et al. 2016

Food Chemistry

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ANTIBIOTICS AND DRUGS | Uses in Food Production

Cited by 6 publications

References 0 publications

Quantification of Antibiotic Residues and Determination of Antimicrobial Resistance Profiles of Microorganisms Isolated from Bovine Milk in Lebanon

Quantification of Antibiotic Residues and Determination of Antimicrobial Resistance Profiles of Microorganisms Isolated from Bovine Milk in Lebanon

Histidine Functionalized Gold Nanoparticles for Screening Aminoglycosides and Nanomolar Level Detection of Streptomycin in Water, Milk, and Whey

Monitoring of twenty-two sulfonamides in edible tissues: Investigation of new metabolites and their potential toxicity

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