Antibiotics and Congenital Malformations

Carter, M.P; Wilson, F.

doi:10.1016/s0140-6736(63)91904-4

Cited by 25 publications

(1 citation statement)

References 3 publications

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“…Only one reference has linked the use of penicillin G with CA (Carter and Wilson, 1963). An examination of hospital records indicated that in three of four cases the administration of penicillin G had been followed by the birth of newborn infants with CA.…”

Section: Discussionmentioning

confidence: 99%

A Population‐based Case‐Control Teratological Study of Three Parenteral Penicillins G

Czeizel

Rockenbauer

Sørensen

et al. 1999

Congenital Anomalies

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The purpose of the study was to check the human teratogenic potential of three penicillins G: parenteral treatments with benzylpenicillin, benzylpenicillin‐procaine, and benzylpenicillin + benzylpenicillin‐procaine during pregnancy in the population‐based dataset of the Hungarian Case‐Control Surveillance of Congenital Abnormalities, 1980–1996. Of 38,151 pregnant women who had babies without any defects (population control group), 303 (0.8%) were treated with penicillin G. Of 22,865 pregnant women who had offspring with congenital abnormalities, 236 (1.O%) were treated with penicillin G (crude OR with 95% CI = 1.3, 1.1–1.5). Of 812 mothers who deliveried babies affected with Down syndrome (patient controls), 15 (1.8%) had penicillin G treatment, and this rate exceeded significantly the figure of both the case and population control groups. This finding needs further studies. The case‐control pair analysis did not indicate a teratogenic risk of three parenteral penicillin G treatments during the second‐third months of gestation, i.e., in the critical period for major congenital abnormalities. The lower use of penicillins G was explained mainly by recall bias in the population control group. Thus, parenteral penicillin G treatments during pregnancy do not present a detectable teratogenic risk to the fetus.

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Section: Discussionmentioning

confidence: 99%

A Population‐based Case‐Control Teratological Study of Three Parenteral Penicillins G

Czeizel

Rockenbauer

Sørensen

et al. 1999

Congenital Anomalies

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Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

et al. 1996

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Maternal medication during the first trimester of pregnancy has been discussed as a risk factor for development of birth defects. The correlation between maternal drug use and major malformations was investigated in a population‐based case‐control study in Mainz. Over a period of 5 years (1990–1994), 20,248 livebirths, stillbirths, and abortions underwent physical and sonographic examination, and anamnestic data were collected. A total of 1,472 births with congenital anomalies (cases) and 9,682 births without major and minor malformations (controls) were analyzed. We distinguished between 30 different drug categories, which were divided into medication taken continuously (before and during pregnancy; CM) and acute medication (drugs given within the first 3 months of gravidity; AM). Statistically highly‐significant results [CM: Odds Ratios (OR) 1.2, Confidence Intervals (CI) 1.1–1.4, P = 0.008; AM: OR 1.2, CI 1.1–1.3, P = 0.008] were established for maternal drug use in correlation to birth defects. For the majority of combinations between drugs and specific malformations no teratogenic risks were found. However, statistically significant associations were recorded for antiallergics and heart anomalies (CM, AM) as well as musculoskeletal anomalies (AM); for bronchodilators and heart anomalies (CM, AM); for antiepileptics and anomalies of the internal urogenital system (CM), as well as cleft palate/cleft lips (AM); for thyroid hormones and anomalies of the nervous system (CM, AM), as well as anomalies of the external urogenital system (CM, AM); for insulin and anomalies of the musculoskeletal system (CM); for digitalis and anomalies of the musculoskeletal system (AM). © 1996 Wiley‐Liss, Inc.

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Congenital malformation case reports: The editor's and reviewer's dilemma

Brent

1993

Am. J. Med. Genet.

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Antibiotics and Congenital Malformations

Cited by 25 publications

References 3 publications

A Population‐based Case‐Control Teratological Study of Three Parenteral Penicillins G

A Population‐based Case‐Control Teratological Study of Three Parenteral Penicillins G

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

Congenital malformation case reports: The editor's and reviewer's dilemma

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